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Chemical Sampling Information (CSI)
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General Description

Synonyms: 3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin; 4-Hydroxy-3-(3-oxo-1-phenyl butyl)-2H-1-benzopyran-2-one; WARF; Coumadin; D-con

OSHA IMIS Code Number: 2586

Chemical Abstracts Service (CAS) Registry Number: 81-81-2

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: GN4550000

NIOSH Pocket Guide to Chemical Hazards, Warfarin: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Table Z-1 - 0.1 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A - 0.1 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards - 0.1 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 mg/m3 TWA

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 100 mg/m3

Potential Symptoms: Hematuria; back pain; hematoma in arms, legs; epistaxis, bleeding lips; mucous membrane hemorrhage; abdominal pain, vomiting, fecal blood; petechial rash; abnormal hematology; pallor

Health Effects: Cumulative anticoagulant effect---Bleeding disorders, hemorrhagic shock (HE3); suspect teratogen (HE5)

Affected Organs: Blood, cardiovascular system

Notes:

  1. In addition to its use as a rodenticide, warfarin is used as an anticoagulant drug, which interferes with the vitamin K-dependent synthesis of clotting factors II, VII, IX, and X, as well as proteins C and S, in the liver.
  2. The S-enantiomer of warfarin is 7-hydroxylated by the liver enzyme CYP2C9, which displays genetic polymorphism that occurs with greater frequency in Caucasians than in Asians or African-Americans.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Warfarin.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Warfarin.
  • Pohanish, R.P. (editor): Warfarin. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2337-2339.
  • Wittkowsky, A.K.: Warfarin and other coumarin derivatives: pharmacokinetics, pharmacodynamics, and drug interactions. Semin. Vasc. Med. 3(3): 221-230, 2003.

Date Last Revised: 08/19/2004

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Polytetrafluoroethylene (FA) filter 1.0 micron
    maximum volume: 1,000 Liters
    maximum flow rate: 3.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: NIOSH Analytical Method (NIOSH 5002 [17 KB PDF, 3 pages])
    method classification: Partially Validated

Bulk Method:

  • Limit the amount of bulk submitted to one gram or one mL.

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