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Toluene-2,4-Diisocyanate (TDI)

General Description

Synonyms:  2,4-Diisocyanato-1-methylbenzene; TDI; 2,4-TDI; 2,4-Toluene diisocyanate

OSHA IMIS code: 2470 [IMIS History: Toluene-2,4-Diisocyanate prior to 9/1/89]

CAS number(s): 584-84-9

Exposure Limits and Health Effects (Updated September 6, 2012)

Standard Set By Exposure Limit Health Effect Codes -- Health Effects and Target Organs
OSHA PEL - General Industry
See 29 CFR 1910.1000 Table Z-1
0.02 ppm (0.14 mg/m3) Ceiling
HE9 -- Allergic sensitization of respiratory tract; asthma
OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A
0.02 ppm (0.14 mg/m3) Ceiling
HE9 -- Allergic sensitization of respiratory tract; asthma
OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z - Shipyards
0.02 ppm (0.14 mg/m3) Ceiling
HE9 -- Allergic sensitization of respiratory tract; asthma
NIOSH REL Lowest Feasible Concentration 
Ca
HE2 -- carcinogenicity (pancreas, liver, skin, mammary glands, and circulatory system)
ACGIH TLV® (2015) 0.001 ppm (0.007 mg/m3) (inhalable fraction and vapor) TWA
0.005 ppm (0.035 mg/m3) (inhalable fraction and vapor) STEL
Skin; dermal sensitizer (DSEN); respiratory sensitizer (RSEN)
A3
HE9 -- allergic sensitization of respiratory tract; asthma
HE11 -- bronchitis, pneumonitis, pulmonary edema
HE14 -- eye, mucous membrane, and respiratory irritation
CAL/OSHA PELs 0.005 ppm (0.04 mg/m3) TWA
0.02 ppm Ceiling
0.02 ppm (0.15 mg/m3) STEL
HE9 -- allergic sensitization of respiratory tract; asthma
HE11 -- bronchitis, pneumonitis, pulmonary edema
HE14 -- eye, mucous membrane, and respiratory irritation

Carcinogenic classification:

EPA Inhalation Reference Concentration (RfC): Not established

ATSDR Inhalation Minimal Risk Levels (MRLs): Not established

NIOSH IDLH concentration: 2.5 ppm

Notes on other potential health effects and hazards:

  1. Toluene-2, 4-diisocyanate is combustible and can give off toxic fumes in a fire (NIOSH/IPCS 1995).
  2. Death from severe asthma in sensitized workers has been reported (NIOSH 1996).
  3. Once sensitized, workers may continue to exhibit the health effects of TDI several years after exposure has ended (ACGIH 2004).
  4. Individuals sensitized to TDI may develop a chronic-like syndrome that includes coughing, wheezing, tightness or congestion in the chest, and shortness of breath (ACGIH 2004).

Partial reference list:

Chemical Sampling Information

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