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Chemical Sampling Information (CSI)
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General Description

Synonyms: Anatase; Brookite; Rutile; Titanium oxide; Titanium peroxide

OSHA IMIS Code Number: 2440

Chemical Abstracts Service (CAS) Registry Number: 13463-67-7

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: XR2275000

NIOSH Pocket Guide to Chemical Hazards, Titanium dioxide: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 15 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 15 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 10 mg/m3 TWA; Appendix A4 - Not Classifiable as a Human Carcinogen

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Appendix A - NIOSH Potential Occupational Carcinogens

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 5,000 mg/m3

Potential Symptoms: Slight lung fibrosis; (carcinogenic in rats)

Health Effects: Nuisance particulate-Accumulation in lungs (HE19)

Affected Organs: Respiratory system

Notes:

  1. One of the 20 occupational fatalities reported to poison control centers in 2001 was attributed to titanium dioxide inhalation.
  2. A recent epidemiological study found no increase in risk for lung cancer (or any other specific cause of death) among titanium dioxide manufacturing workers.

Literature Basis:

  • (IDLH, target organ)
    NIOSH Pocket Guide to Chemical Hazards: Titanium dioxide.
  • (fatality)
    Litovitz, T.L., et al.: 2001 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am. J. Emerg. Med. 20(5): 391-452, 2002.
    Fryzek, J.P., et al.: A cohort mortality study among titanium dioxide manufacturing workers in the United States. J. Occup. Environ. Med. 45(4): 400-409, 2003.

Date Last Revised: 07/24/2003

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: tared 37-mm diameter low-ash polyvinyl chloride filter
    maximum volume: 480 Liters
    maximum flow rate: 2.0 L/min
    current analytical method: Gravimetric
    method reference: OSHA Analytical Method (OSHA PV2121)
    method classification: Partially Validated
    note: OSHA personnel can obtain tared sampling media from the Salt Lake Technical Center.
    note: If the net weight of the sample yields a concentration below the standard for the substance, the Salt Lake Technical Center will perform no further work on that sample. If the net weight corresponds to an amount greater than the standard, the sample may be analyzed for the appropriate element and the result reported as the substance.
    current elemental analysis method: Atomic Absorbtion Spectroscopy; AAS
    method reference: OSHA Analytical Method (OSHA ID-121)
    method classification: Fully Validated
    note: An elemental analysis is performed for total titanium and reported as the compound.

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