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Chemical Sampling Information (CSI)
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General Description

Synonyms: Freon 134a; HFA 134a; HFC 134a; Norflurane; Refrigerant R134a; SUVA-134a

OSHA IMIS Code Number: R225

Chemical Abstracts Service (CAS) Registry Number: 811-97-2

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KI8842500

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 3159 126

Chemical Description and Physical Properties:

colorless gas with slight ethereal odor
molecular weight: 102.03
vapor pressure: 630 kPa @ 25°C
molecular formula: C2H2F4
boiling point: -26.2°C
melting point: -101°C

Health Factors

Potential Symptoms: Dizziness, drowsiness, dullness; frostbite (on contact with liquid)

Health Effects: Narcosis (HE8)

Affected Organs: CNS, skin

Notes:

  1. OSHA does not have a PEL for 1,1,1,2-tetrafluoroethane.
  2. EPA's inhalation reference concentration (daily inhalational exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for 1,1,1,2-tetra-fluoroethane is 80 mg/m3.
  3. Because of its use in metered-dose inhalers, 1,1,1,2-tetrafluoroethane has been studied in human volunteers with single-breath inhalation and one-hour exposures to concentrations up to 8000 ppm, which caused no respiratory irritation or adverse effects on pulse, blood pressure, lung function, electrocardiogram or on the CNS.

Literature Basis:

  • International Chemical Safety Cards (WHO/IPCS/ILO): 1,1,1,2-Tetrafluoroethane.
  • U.S. EPA Integrated Risk Information System: 1,1,1,2-Tetrafluoroethane (CASRN 811-97-2).
  • Emmen, H.H., et al.: Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3,3-heptafluoropropane) following whole-body exposure. Regul. Toxicol. Pharmacol. 32(1): 22-35, 2000.
  • Pike, V.W., et al.: Disposition of inhaled 1,1,1,2-tetrafluoroethane (HFA134A) in healthy subjects and in patients with chronic airflow limitation. Measurement by 18F-labeling and whole-body γ-counting. Drug. Metab. Dispos. 23(8): 832-839, 1995.

Date Last Revised: 07/28/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Two Anasorb CMS tubes in series (150/75 mg sections)
    analytical solvent: (60:40) DMF:Carbon Disulfide
    maximum volume: 1 Liter
    maximum flow rate: 0.05 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Salt Lake Technical Center In-House File
    method classification: Not Validated

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