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Chemical Sampling Information (CSI)
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General Description

Synonyms: Andro; D4-Androsten-17b-ol-3-one; (17b)-17-Hydroxyandrost-4-en-3-one; Mertestate: Oreton; Testoderm; Testolin; Testro AQ; Virosterone

OSHA IMIS Code Number: T413

Chemical Abstracts Service (CAS) Registry Number: 58-22-0

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: XA3066000

Chemical Description and Physical Properties:

odorless, tasteless white crystals or crystalline powder
molecular weight: 288.39
molecular formula: C19H28O2
melting point: 155°C

Health Factors

Potential Symptoms: IN MEN: Weight gain; testicular atrophy, oligospermia, azoospermia, priapism (at supraphysiologic doses); increased aggressiveness; IN WOMEN: Acne vulgaris; hirsutism; seborrhea; female-pattern alopecia; deepening of the voice; menstrual irregularities.

Health Effects: Androgenic changes (virilization) in women (HE3); Sterility in men (HE5)

Affected Organs: Male and female reproductive systems; skin (pilosebaceous unit)

Notes:

  1. OSHA does not have a PEL for testosterone, but it is listed in a NIOSH Alert as a drug that should be handled as a hazardous drug.
  2. Plasma testosterone levels decline with age in both men and women, but are higher in men at any age.
  3. The mean production rate of testosterone in women with female-pattern hair loss was reported to be at least double the mean rate in normal women.
  4. Testosterone-induced changes in voice and pattern alopecia are considered to be irreversible, whereas partial reversal of hirsutism is possible.

Literature Basis:

  • National Institute for Occupational Safety and Health: NIOSH Alert: Preventing Occupational Exposure to Antineoplastic and Other Hazardous Drugs in Health Care Settings. NIOSH Publication No. 2004-165.
  • Abitbol, J., Abitbol, P. and Abitbol, B.: Sex hormones and the female voice. J. Voice 13(3): 424-446, 1999.
  • Davison, S., et al.: Pharmacokinetics and acute safety of inhaled testosterone in postmenopausal women. J. Clin. Pharmacol. 45(2): 177-184, 2005.
  • Giammanco, M., Tabacchi, G., Giammanco, S., Di Majo, D. and La Guardia, M.: Testosterone and aggressiveness. Med. Sci. Monit. 11(4): RA136-145, 2005.
  • Rhoden, E.L. and Morgentaler, A.: Risks of testosterone-replacement therapy and recommendations for monitoring. N. Engl. J. Med. 350(5): 482-492, 2004.
  • Rosenfeld, R.L.: Hirsutism and the variable response of the pilosebaceous unit to androgen. J. Investig. Dermatol. Symp. Proc. 10(3): 205-208, 2005.
  • Trenton, A.J. and Currier, G.W.: Behavioral manifestations of anabolic steroid use. CNS Drugs 19(7): 571-595, 2005.
  • Vierhapper, H., Nowotny, P. and Waldhusl, W.: Determination of testosterone production rates in men and women using stable isotope/dilution and mass spectrometry. J. Clin. Endocrinol. Metab. 82(5): 1492-1496, 1997.
  • Vierhapper, H., Maier, H., Nowotny, P. and Waldhusl, W.: Production rates of testosterone and of dihydrotestosterone in female pattern hair loss. Metabolism 52(7): 727-729, 2003.
  • World Health Organization: Contraceptive efficacy of testosterone-induced azospermia and oligospermia in normal men. Fertil. Seril. 65(4): 821-829, 1996.
  • Zouboulis, C.C., Chen, W.C., Thornton, M.J. Qin, K. and Rosenfield, R.: Sexual hormones in human skin. Horm. Metab. Res. 39(2): 85-95, 2007.
  • Zumoff, B., Strain, G.W., Miller, L.K. and Rosner, W.: Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. J. Clin. Endocrinol. Metab. 80(4): 1429-1430, 1995.

Date Last Revised: 06/04/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Glass Fiber Filter (37 mm) in 3-piece cassette
    analytical solvent: Methanol
    maximum volume: 240 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV at 240nm
    method reference: OSHA Analytical Method (OSHA PV2001)
    method classification: Partially Validated

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