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Ozone

General Description

  • Synonyms: Triatomic oxygen
  • OSHA IMIS Code Number: 1980
  • Chemical Abstracts Service (CAS) Registry Number: 10025-15-6
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: RS8225000
  • NIOSH Pocket Guide to Chemical Hazards - Ozone: Physical description, chemical properties, potentially hazardous incompatibilities, and more

Exposure Limits and Health Effects

Exposure Limit Limit Values HE Codes Health Factors and Target Organs

0.1 ppm
(0.2 mg/m3) TWA

HE7

Headache
Target organs: Brain, central nervous system

HE10 Lung damage, chronic respiratory disease
HE11 Pulmonary congestion, edema, and hemorrhage
HE14 Eye, nose, throat, and respiratory irritation

0.1 ppm
(0.2 mg/m3) TWA

HE7

Headache
Target organs: Brain, central nervous system

HE10 Lung damage, chronic respiratory disease
HE11 Pulmonary congestion, edema, and hemorrhage
HE14 Eye, nose, throat, and respiratory irritation

0.1 ppm
(0.2 mg/m3) TWA

HE7

Headache
Target organs: Brain, central nervous system

HE10 Lung damage, chronic respiratory disease
HE11 Pulmonary congestion, edema, and hemorrhage
HE14 Eye, nose, throat, and respiratory irritation
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL)
0.1 ppm
(0.2 mg/m3) Ceiling

HE7

Headache
Target organs: Brain, central nervous system

HE10 Lung damage, chronic respiratory disease
HE11 Pulmonary congestion, edema, and hemorrhage
HE14 Eye, nose, throat, and respiratory irritation

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2001)

  • Heavy work:
  • 0.05 ppm
  • (0.1 mg/m3)
  • 8-hour TWA
  • Moderate work:
  • 0.08 ppm
  • (0.16 mg/m3)
  • 8-hour TWA
  • Light work:
  • 0.1 ppm
  • (0.2 mg/m3)
  • 8-hour TWA
  • All workloads:
  • 0.2 ppm
  • (0.39 mg/m3)
  • 2-hour TWA
  • A4

HE7

Headache
Target organs: Brain, central nervous system

HE10 Lung damage, chronic respiratory disease
HE11 Pulmonary congestion, edema, and hemorrhage
HE14 Eye, nose, throat, and respiratory irritation

CAL/OSHA PEL

0.1 ppm
(0.2 mg/m3)
TWA

0.3 ppm
(0.6 mg/m3) STEL

HE10

Lung damage and decreased lung function

  • National Toxicology Program (NTP) carcinogenic classification: Not Listed
  • International Agency for Research on Cancer (IARC): Not Listed
  • U.S. Environmental Protection Agency (EPA) carcinogenic classification: Not listed
  • EPA Inhalation Reference Concentration (RfC): Not established
  • Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established
  • NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: 5 ppm
  • Notes on Other Potential Health Effects and Hazards
    1. Ozone can increase sensitivity to bronchoconstrictors and allergens and may facilitate the development of asthma. In fact, thunderstorm events (when pollen and ozone are at higher levels), have coincided with up to 10-fold increases in asthma hospital admissions (Anderson et al. 2001).
    2. Systemically, ozone has been reported to mimic the effects of ionizing radiation, including damage to chromosomal structures. There does, however, appear to be a partial tolerance to this with repeated exposure (NIOSH 1978).
    3. In bleachery workers, exhaled nitric oxide levels could be a marker for airway inflammation after exposure to high peaks of ozone (Olin et al. 2004).
  • Date Last Revised: 09/06/2012
  • Literature Basis
    • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Ozone. 2001.
    • Anderson, W., Prescott, G.J., Packham, S., Mullins, J., Brookes, M. and Seaton, A.: Asthma admissions and thunderstorms: a study of pollen, fungal spores, rainfall, and ozone. QJM 94(8): 429-433, 2001.
    • California Occupational Safety & Health Standards Board: Initial (PDF) and Final (PDF) Statement of Reasons. August 3, 2010.
    • NIOSH: Occupational Health Guideline for Ozone. September 1978.
    • NIOSH/IPCS: International Chemical Safety Cards - Ozone. April 26, 1993.
    • Olin, A.C., Andersson, E., Andersson, M., Granung, G., Hagberg, S. and Toren, K.: Prevalence of asthma and exhaled nitric oxide are increased in bleachery workers exposed to ozone. Eur. Respir. J. 23(1): 87-92, 2004.

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • Two impregnated glass fiber filters (37-mm polystyrene cassette) coated with a solution containing NaNO2, K2CO3 and glycerol in water
  • recommended minimum volume: 90 Liters
  • maximum flow rate: 0.5 L/min
  • recommended minimum time: 180 Minutes
  • current analytical method: Ion Chromatography; IC
  • method reference: OSHA Analytical Method (OSHA ID-214)
  • method classification: Fully Validated
  • notes:
    1. OSHA personnel can request the sampling medium from the Salt Lake Technical Center (SLTC).
    2. The sampling medium must be used within 30 days of preparation.
    3. Sulfur dioxide (SO2) is a sampling interference, and oxidizer tubes must be used if SO2 is suspected to be present.
    4. The sampling medium is shipped from the Salt Lake Technical Center (SLTC) in cassettes and each cassette is individually sealed in an aluminized plastic bag to prevent contamination. Each exposed sampler must be returned for analysis also sealed in an aluminized plastic bag.

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