Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established
NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: 1,000 ppm
Notes on Other Potential Health Effects and Hazards
Methyl methacrylate is highly flammable, and vapor/air mixtures may be explosive (NIOSH/IPCS 2003).
The U.S. Environmental Protection Agency's (EPA's) oral reference dose (RfD) for methyl methacrylate is 1.4 mg/kg/day (EPA 1998).
Adverse reactions to cosmetic fingernail preparations have resulted in dermatitis and prolonged paresthesia (Fisher and Baran 1991; Freeman et al. 1995).
Because acrylate-based materials have largely replaced amalgams in restorative dentistry, dental personnel represent another occupational group at risk for developing contact allergy to methyl methacrylate (Piirilä et al. 1998).
Methanol is a hydrolysis product of methyl methacrylate in the body and has been proposed as a biological marker of occupational exposure to airborne methyl methacrylate when measured in blood, serum, or urine. In one study, end of workday levels of approximately 8.2 mg and 14.5 mg methanol per liter of urine were suggested to correspond to TWA exposure levels of 50 ppm and 100 ppm, respectively (Mizunuma et al. 1993).
ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Methyl Methacrylate. 2001.
California Occupational Safety & Health Standards Board: Initial (PDF) and Final (PDF) Statement of Reasons. July 6, 2006.
All other documents, that are not PDF materials or formatted for the web, are available as Microsoft Office® formats and videos and are noted accordingly. If additional assistance is needed with reading, reviewing or accessing these documents or any figures and illustrations, please also contact OSHA's Directorate of Technical Support and Emergency Management at (202) 693-2300.
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