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Chemical Sampling Information (CSI)
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General Description

Synonyms: Methacrylate monomer; Methyl ester of methacrylic acid; Methyl-2-methyl-2-propenoate; Methyl propionate

OSHA IMIS Code Number: 1774

Chemical Abstracts Service (CAS) Registry Number: 80-62-6

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: OZ5075000

Department of Transportation Regulation Number (49 CFR 172.101) and 2012 Emergency Response Guidebook [4 MB PDF, 392 pages]: 1247 129

NIOSH Pocket Guide to Chemical Hazards - Methyl Methacrylate: Physical description, chemical properties, potentially hazardous incompatibilities, and more

U.S. Environmental Protection Agency (EPA) Hazard Summary - Methyl Methacrylate: Uses, sources and potential exposure, acute and chronic health hazard information, and more

Exposure Limits and Health Effects

Exposure Limit

Limit Values

HE Codes

Health Factors and Target Organs

OSHA Permissible Exposure Limit (PEL) - General Industry
See 29 CFR 1910.1000 Table Z-1

100 ppm
(410 mg/m3) TWA



Eye, skin, and respiratory irritation


OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A

100 ppm
(410 mg/m3) TWA


Eye, skin, and respiratory irritation

OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z-Shipyards

100 ppm
(410 mg/m3) TWA


Eye, skin, and respiratory irritation

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL)

100 ppm
(410 mg/m3) TWA


Eye, skin, nose, and respiratory irritation; dermatitis

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2001)

50 ppm
(205 mg/m3) TWA

100 ppm
(410 mg/m3) STEL



Pulmonary deficits, pulmonary edema


HE15 Ocular and respiratory irritation, allergic dermatitis, erythema, decreased olfactory function

50 ppm
(205 mg/m3) TWA

100 ppm
(410 mg/m3) STEL



Decreased pulmonary function

HE15 Decreased olfactory function

National Toxicology Program (NTP) carcinogenic classification: Not listed

International Agency for Research on Cancer (IARC): Group 3 [89 KB PDF, 31 pages] (not classifiable as to its carcinogenicity to humans)

EPA carcinogenic classification: Not likely to be carcinogenic to humans

EPA Inhalation Reference Concentration (RfC): 7x10-1 mg/m3

Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established

NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: 1,000 ppm

Notes on Other Potential Health Effects and Hazards

  1. Methyl methacrylate is highly flammable, and vapor/air mixtures may be explosive (NIOSH/IPCS 2003).
  2. The U.S. Environmental Protection Agency's (EPA's) oral reference dose (RfD) for methyl methacrylate is 1.4 mg/kg/day (EPA 1998).
  3. Adverse reactions to cosmetic fingernail preparations have resulted in dermatitis and prolonged paresthesia (Fisher and Baran 1991; Freeman et al. 1995).
  4. Because acrylate-based materials have largely replaced amalgams in restorative dentistry, dental personnel represent another occupational group at risk for developing contact allergy to methyl methacrylate (Piirilä et al. 1998).
  5. Methanol is a hydrolysis product of methyl methacrylate in the body and has been proposed as a biological marker of occupational exposure to airborne methyl methacrylate when measured in blood, serum, or urine. In one study, end of workday levels of approximately 8.2 mg and 14.5 mg methanol per liter of urine were suggested to correspond to TWA exposure levels of 50 ppm and 100 ppm, respectively (Mizunuma et al. 1993).

Date last revised: 09/06/2012

Literature Basis

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Methyl Methacrylate. 2001.
  • California Occupational Safety & Health Standards Board: Initial [70 KB PDF, 11 pages] and Final [124 KB PDF, 10 pages] Statement of Reasons. July 6, 2006.
  • EPA: Integrated Risk Information System - Methyl Methacrylate (CASRN 80-62-6). March 2, 1998.
  • Fisher, A.A. and Baran, R.L.: Adverse reactions to acrylate sculptured nails with particular reference to prolonged paresthesia. Am. J. Contact Dermatitis 2(1): 38-42, 1991.
  • Freeman, S., Lee, M.-S. and Gudmundsen, K.: Adverse contact reactions to sculpted acrylic nails: 4 case reports and a literature review. Contact Dermatitis 33(6): 381-385, 1995.
  • Mizunuma, K., et al.: Biological monitoring and possible health effects in workers occupationally exposed to methyl methacrylate. Int. Arch. Occup. Environ. Health 65(4): 227-232, 1993.
  • NIOSH: Occupational Health Guideline for Methyl Methacrylate. September 1978.
  • NIOSH/IPCS: International Chemical Safety Cards - Methyl methacrylate. November 26, 2003.
  • Piirilä, P., et al.: Occupational respiratory hypersensitivity caused by preparations containing acrylates in dental personnel. Clin. Exp. Allergy 28(11): 1404-1411, 1998.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:

  • sampling media: Coated Charcoal Tube (110/55 mg sections; 20/40 mesh); Coating is 10% (w/w) 4-t-Butylcatechol
    analytical solvent: Toluene
    alternate analytical solvent: Carbon Disulfide
    maximum volume: 3 Liters
    maximum flow rate: 0.05 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 94)
    method classification: Fully Validated
  • sampling media: XAD-2 Tube (400/200 mg sections; 20/50 mesh)
    analytical solvent: Carbon Disulfide
    maximum volume: 8 Liters
    maximum flow rate: 0.05 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 2537 [95 KB PDF, 4 pages])
    method classification: Fully Validated
    note: ship cold.
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