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Methylene Bisphenyl Isocyanate

General Description

Synonyms: 4,4-Diphenylmethane diisocyanate; MDI; 4,4-Diisocyanadiphenyl-methane; Methylenebis(4-phenylisocyanate); Methylene bis(phenyl isocyanate); Methylene di-p-phenylene ester of isocyanic acid

OSHA IMIS code: 1073

CAS number: 101-68-8

Exposure Limits and Health Effects (Updated September 6, 2012)

Standard Set By Exposure Limit Health Effect Codes -- Health Effects and Target Organs
OSHA PEL - General Industry
See 29 CFR 1910.1000 Table Z-1
0.02 ppm (0.2 mg/m3) Ceiling
HE9 -- respiratory sensitization
OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A
0.02 ppm (0.2 mg/m3) Ceiling
HE9 -- respiratory sensitization
OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z - Shipyards
0.02 ppm (0.2 mg/m3) Ceiling
HE9 -- respiratory sensitization
NIOSH REL 0.005 ppm (0.05 mg/m3) TWA
0.020 ppm (0.2 mg/m3) Ceiling (10 minutes)
HE9 -- pulmonary sensitization, asthma
HE11 -- pulmonary edema
HE14 -- eye, mucous membrane, and skin irritation
ACGIH TLV® (1985) 0.005 ppm (0.051 mg/m3) TWA HE9 -- respiratory sensitization
HE11 -- decreased pulmonary function
CAL/OSHA PELs 0.005 ppm (0.051 mg/m3) TWA
HE9 -- respiratory sensitization
HE11 -- decreased pulmonary function

Carcinogenic classification:

EPA Inhalation Reference Concentration (RfC): 6x10-4 mg/m3

ATSDR Inhalation Minimal Risk Levels (MRLs): Not established

NIOSH IDLH concentration: 75 mg/m3

Notes on other potential health effects and hazards:

No other potential health effects or hazards resulting from occupational exposure were found in the scientific literature.

Partial reference list:

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Methylene Bisphenyl Isocyanate. 2016.
  • NIOSH: Occupational Health Guideline for Methylene Bisphenyl Isocyanate. 1978.

Chemical Sampling Information

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