Manganese Compounds (as Mn)
- OSHA IMIS Code Number: M112
- Chemical Abstracts Service (CAS) Registry Number: 7439-96-5
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: OO9275000
- NIOSH Pocket Guide to Chemical Hazards, Manganese compounds and fume (as Mn): chemical description, physical properties, potentially hazardous incompatibilities, and more
- OSHA Permissible Exposure Limit (PEL):
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2012): 0.2 mg/m3 TWA (respirable fraction), 0.1 mg/m3 TWA (inhalable fraction); A4
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1 mg/m3 TWA; 3 mg/m3 STEL
- NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 mg Mn/m3
- Potential Symptoms: Irritation eyes, skin, respiratory system; eye, skin burns (from prolonged direct contact with dust or concentrated liquid); conjunctivitis; blindness; dermatitis; cough, chest tightness, dyspnea, rales; pulmonary edema; bronchitis, pneumonitis; anorexia, weakness, sleepiness; parkinsonism (gait disturbances, clumsiness, tremor, speech disturbances, mask-like facial expression, and personality changes); kidney damage, liver damage; methemoglobinemia, anemia (from manganese nitrate); INGES ACUTE (50% manganese nitrate solution): Burning sensation, mouth, throat; abdominal pain, nausea, vomiting, diarrhea; convulsions; collapse (can be fatal)
- Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15); Cumulative CNS damage (HE7); Lung damage---Acute (HE11) and Cumulative (HE10)
- Affected Organs: Respiratory system, CNS, blood, kidneys
- Inhalational toxicokinetic studies with rats indicate achievement of higher brain levels of manganese with Mn phosphate or Mn phosphate/sulfate mixture than with metallic Mn dust.
- One Mn-containing compound, mangafodipir trisodium, is used intravenously in radiology as a liver contrast agent. A study in dogs reported that some Mn in this agent may be redistributed to the brain and adrenals under certain circumstances.
- Chronic exposure to a Mn-containing fungicide (maneb) was reported to cause parkinsonism.
- Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Manganese compounds and fume (as Mn).
- EPA Air Toxics Website: Manganese Compounds. U.S. Environmental Protection Agency Technology Transfer Network.
- Grant, D., Toft, K.G., Martinsen, I. and Atzpodien, E.: Tissue distribution and general safety of MnDPDP in male beagle dogs, with or without total common bile duct obstruction. Acta Radiol. 38(4 Pt. 2): 732-739, 1997.
- Meco, G., Bonifati, V., Vanacore, N. and Fabrizio, E.: Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate). Scand. J. Work Environ. Health 20(4): 301-305, 1994.
- Mineral Research and Development (Charlotte, NC): Material Safety Data Sheet: Manganese (II) Nitrate Solution (Jan. 30, 2003) 8 pp.
- Normandin, L., et al.: Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese. Neurotoxicology 25(3): 433-441, 2004.
- Pohanish, R.P. (editor): Manganese Nitrate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1448-1450.
- Date Last Revised: 06/22/2004
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Mixed Cellulose Ester Filter (MCEF) 0.8 microns
- maximum volume: 960 Liters
- minimum volume: 480 Liters
- maximum flow rate: 2.0 L/min (TWA)
- maximum volume: 30 Liters
- maximum flow rate: 2.0 L/min (STEL)
- maximum volume: 10 Liters
- minimum time: 5 Minutes
- maximum flow rate: 2.0 L/min (Ceiling)
- current analytical method: Atomic Absorption Spectroscopy; AAS
- method reference: OSHA Analytical Method (OSHA ID-121)
- method classification: Fully Validated
- alternative analytical method: Inductively Coupled Argon Plasma; ICP/DCP-AES
- method reference: OSHA Analytical Method (OSHA ID-125G)
- method classification: Fully Validated
- note: Samples may be collected up to an 8 hour period, if the filter is not overloaded. When analysis of a compound is requested, an elemental analysis is performed and reported as the element.
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