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Manganese Compounds (as Mn)

General Description

  • OSHA IMIS Code Number: M112

  • Chemical Abstracts Service (CAS) Registry Number: 7439-96-5

  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: OO9275000
  • NIOSH Pocket Guide to Chemical Hazards, Manganese compounds and fume (as Mn): chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2012): 0.2 mg/m3 TWA (respirable fraction), 0.1 mg/m3 TWA (inhalable fraction); A4
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1 mg/m3 TWA; 3 mg/m3 STEL

Health Factors

  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 mg Mn/m3
  • Potential Symptoms: Irritation eyes, skin, respiratory system; eye, skin burns (from prolonged direct contact with dust or concentrated liquid); conjunctivitis; blindness; dermatitis; cough, chest tightness, dyspnea, rales; pulmonary edema; bronchitis, pneumonitis; anorexia, weakness, sleepiness; parkinsonism (gait disturbances, clumsiness, tremor, speech disturbances, mask-like facial expression, and personality changes); kidney damage, liver damage; methemoglobinemia, anemia (from manganese nitrate); INGES ACUTE (50% manganese nitrate solution): Burning sensation, mouth, throat; abdominal pain, nausea, vomiting, diarrhea; convulsions; collapse (can be fatal)
  • Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15); Cumulative CNS damage (HE7); Lung damage---Acute (HE11) and Cumulative (HE10)
  • Affected Organs: Respiratory system, CNS, blood, kidneys
  • Notes:
    1. Inhalational toxicokinetic studies with rats indicate achievement of higher brain levels of manganese with Mn phosphate or Mn phosphate/sulfate mixture than with metallic Mn dust.
    2. One Mn-containing compound, mangafodipir trisodium, is used intravenously in radiology as a liver contrast agent. A study in dogs reported that some Mn in this agent may be redistributed to the brain and adrenals under certain circumstances.
    3. Chronic exposure to a Mn-containing fungicide (maneb) was reported to cause parkinsonism.
  • Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: Manganese compounds and fume (as Mn).
    • EPA Air Toxics Website: Manganese Compounds. U.S. Environmental Protection Agency Technology Transfer Network.
    • Grant, D., Toft, K.G., Martinsen, I. and Atzpodien, E.: Tissue distribution and general safety of MnDPDP in male beagle dogs, with or without total common bile duct obstruction. Acta Radiol. 38(4 Pt. 2): 732-739, 1997.
    • Meco, G., Bonifati, V., Vanacore, N. and Fabrizio, E.: Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate). Scand. J. Work Environ. Health 20(4): 301-305, 1994.
    • Mineral Research and Development (Charlotte, NC): Material Safety Data Sheet: Manganese (II) Nitrate Solution (Jan. 30, 2003) 8 pp.
    • Normandin, L., et al.: Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese. Neurotoxicology 25(3): 433-441, 2004.
    • Pohanish, R.P. (editor): Manganese Nitrate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1448-1450.
  • Date Last Revised: 06/22/2004

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Mixed Cellulose Ester Filter (MCEF) 0.8 microns
  • maximum volume: 960 Liters
  • minimum volume: 480 Liters
  • maximum flow rate: 2.0 L/min (TWA)
  • maximum volume: 30 Liters
  • maximum flow rate: 2.0 L/min (STEL)
  • maximum volume: 10 Liters
  • minimum time: 5 Minutes
  • maximum flow rate: 2.0 L/min (Ceiling)
  • current analytical method: Atomic Absorption Spectroscopy; AAS
  • method reference: OSHA Analytical Method (OSHA ID-121)
  • method classification: Fully Validated
  • alternative analytical method: Inductively Coupled Argon Plasma; ICP/DCP-AES
  • method reference: OSHA Analytical Method (OSHA ID-125G)
  • method classification: Fully Validated
  • note: Samples may be collected up to an 8 hour period, if the filter is not overloaded. When analysis of a compound is requested, an elemental analysis is performed and reported as the element.

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