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Chemical Sampling Information (CSI)
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General Description

Synonyms: 2,5-Furandione; cis-Butenedioic anydride; Toxilic anhydride

OSHA IMIS Code Number: 1618

Chemical Abstracts Service (CAS) Registry Number: 108-31-6

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: ON3675000; 46783

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: UN2215 156 Corrosive

NIOSH Pocket Guide to Chemical Hazards, Maleic Anhydride: chemical description, physical properties, potentially hazardous incompatibilities, and more

Chemical Description and Physical Properties:

colorless or white solid with a penetrating odor
molecular weight: 98
vapor pressure: 0.16 mm
boiling point: 202°F
melting point: 52.8°C

Incompatibilities: Strong oxidizers; alkali metals, caustics, amines at >150°F

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 0.25 ppm, 1 mg/m3

Construction Industry: 0.25 ppm, 1 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.25 ppm, 1 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.25 ppm TWA

Health Factors

Potential Symptoms: Conjunctivitis, photophobia, double vision; nasal, upper respiratory irritation; broncheal asthma; dermatitis

Health Effects: Irritation-Eye, Nose, Throat, Lungs, (Edema), Skin---Marked (HE14) Asthma (HE9); Chronic (Cumulative) Toxicity (HE2)

Affected Organs: Eyes, respiratory system, skin

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Two Coated Glass Fiber Filters (37 mm) Coating is 10 mg Veratryamine and 10 mg di-n-octylphthalate
    analytical solvent: (90:10) Acetonitrile/Dimethylsulfoxide
    maximum volume: 60 Liters
    maximum flow rate: 0.5 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: 2 (OSHA 86)
    method classification: Fully Validated
    note: Store filters under refrigeration and use within 1 month. Small interfering peaks start appearing after that time.

Conditions: Column 10u C8; Mobile Phase Acetonitrile/Water/Phosphoric Acid (30:70:0.1); Flow rate 1.2 mL/min; UV Dectection 254nm Retention Time 6 min.; DL 2 ug/sample

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