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Chemical Sampling Information (CSI)
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General Description

Synonyms: Levothyroxine; T4(hormone); 3,3',5,5'-tetraiodo-L-thyronine

OSHA IMIS Code Number: L200

Chemical Abstracts Service (CAS) Registry Number: 51-48-9

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: YP283350

Chemical Description and Physical Properties:

off-white to cream crystalline powder which is odorless
molecular weight: 776.87
molecular formula: C15H11I4NO4
melting point: 235-236°C (decomposes)

Health Factors

Potential Symptoms: acute irritant to skin, eyes, mucous membranes, and respiratory system; nervousness; sweating; hyperhydrosis; tachycardia; angina pectoris

Health Effects: acute irritant to skin, eyes, mucous membranes, and respiratory system

Affected Organs: skin, eyes, respiratory system, mucous membranes

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Glass Fiber Filter (37 mm) in 3-piece cassette
    analytical solvent: Methanol
    maximum volume: 480 Liters
    maximum flow rate: 2.0 L/min
    maximum time: 240 Minutes
    minimum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV at 230nm
    method reference: 2 (OSHA In-House File)
    method classification: Not Validated

Conditions: Column C18 Mobile Phase: 80/20 MeOH/H2O .2% H3PO4

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