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Chemical Sampling Information (CSI)
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General Description

Synonyms: Isopropanol; IPA; 2-Propanol; sec-Propyl alcohol

OSHA IMIS Code Number: 1560

Chemical Abstracts Service (CAS) Registry Number: 67-63-0

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: NT8050000

Department of Transportation Regulation Number (49 CFR 172.101) and 2012 Emergency Response Guidebook [4 MB PDF, 392 pages]: 1219 129

NIOSH Pocket Guide to Chemical Hazards - Isopropyl alcohol: Physical description, chemical properties, potentially hazardous incompatibilities, and more


Exposure Limits and Health Effects

Exposure Limit

Limit Values

HE Codes

Health Factors and Target Organs

OSHA Permissible Exposure Limit (PEL) - General Industry
See 29 CFR 1910.1000 Table Z-1

400 ppm (980 mg/m3) TWA

HE8

Narcosis

HE16 Mild eye, nose, and throat irritation

OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A

400 ppm (980 mg/m3) TWA

HE8

Narcosis

HE16 Mild eye, nose, and throat irritation

OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z-Shipyards

400 ppm (980 mg/m3) TWA

HE8

Narcosis

HE16 Mild eye, nose, and throat irritation

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL)

400 ppm (980 mg/m3) TWA

500 ppm (1,225 mg/m3) STEL

HE7

Drowsiness, headache, incoordination

HE8 Unconsciousness
HE16 Mild eye, nose, and throat irritation

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2003)

200 ppm (491 mg/m3) TWA

400 ppm (984 mg/m3)
STEL

HE7

Central nervous system effects (changes in postural sway)

HE16 Mild eye, nose, and throat irritation
CAL/OSHA PELs

400 ppm (980 mg/m3)
TWA

500 ppm (1,225 mg/m3) STEL

 

 

National Toxicology Program (NTP) carcinogenic classification: Not listed

International Agency for Research on Cancer (IARC) carcinogenic classification: Group 3 [88 KB PDF, 10 pages] (not classifiable as to its carcinogenicity to humans [isopropyl alcohol and isopropyl oils]); Group 1 [374 KB PDF, 8 pages] (carcinogenic to humans [isopropyl alcohol manufacture by the strong-acid process –this process includes sulfuric acid and other chemicals])

U.S. Environmental Protection Agency (EPA) carcinogenic classification: Not listed

EPA Inhalation Reference Concentration (RfC): Not established

Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established

NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: 2,000 ppm (10% LEL)

Notes on Other Potential Health Effects and Hazards

  1. Small differences reported between men and women in the toxicokinetics of inhaled isopropyl alcohol and its major metabolite, acetone, are largely due to sex differences in body weight and percent body fat (Ernstgård et al. 2003).
  2. Susceptible populations include people with preexisting skin disorders and impaired pulmonary function (NIOSH 1978).
  3. Isopropyl alcohol may cause allergic contact dermatitis (Garcia-Gavin et al. 2011).

Date Last Revised: 09/06/2012

Literature Basis

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Isopropanol. 2003.
  • Ernstgård, L., Sjögren, B., Warholm, M. and Johanson, G.: Sex differences in the toxicokinetics of inhaled solvent vapors in humans. 2. 2-propanol. Toxicol. Appl. Pharmacol. 193(2): 158-167, 2003.
  • Garcia-Gavin, J., Lissens, R., Timmermans, A., Goossens, A.: Allergic contact dermatitis caused by isopropyl alcohol: a missed allergen?. Contact Dermatitis. 65(2):101-106, 2011.
  • NIOSH: Criteria for a Recommended Standard - Occupational Exposure to Isopropyl Alcohol. March 1976.
  • NIOSH: Occupational Health Guideline for Isopropyl Alcohol. September 1978.
  • NIOSH/IPCS: International Chemical Safety Cards - Isopropyl Alcohol. March 23, 1999.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • sampling media: Two Anasorb 747 Tubes (400 mg first/200 mg second)
    analytical solvent: (60:40) Dimethylformamide/Carbon Disulfide
    maximum volume: 18 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 109)
    method classification: Fully Validated
    note: After sampling, separate and cap tubes. Label first and second. Reduced temperature sample shipment required.

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (99:1) Carbon Disulfide/2-Butanol
    alternative solvent: (99:1) Carbon Disulfide/Dimethylformamide
    alternative solvent: (95:5) Methylene Chloride/Methanol
    maximum volume: 3 Liters
    maximum flow rate: 0.2 L/min (TWA)
    maximum volume: 3 Liters
    maximum flow rate: 0.2 L/min (STEL)
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 1400 [25 KB PDF, 4 pages])
    method classification: Fully Validated
    note: The use of charcoal may give low results from high humidity atmospheres due to an insoluble water phase in the sample solution.
On-Site Sampling Techniques/Methods:
  • device: Detector Tube
    manufacturer: Gastec
    model/type: 113
    sampling information: 0.5 to 2 strokes
    upper measurement limit: 5%
    detection limit: 0.004%
    overall uncertainty: 25% for 0.04 to 0.5%, 16% for 0.5 to 2.5%
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Gastec
    model/type: 113L
    sampling information: 1 or 2 strokes
    upper measurement limit: 800 ppm
    detection limit: 5 ppm
    overall uncertainty: 25% for 50 to 200 ppm, 16% for 200 to 800 ppm
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Matheson-Kitagawa
    model/type: 8014-122SA
    sampling information: 1 stroke
    upper measurement limit: 2.5%
    detection limit: approximately 0.02%
    overall uncertainty: unknown
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Matheson-Kitagawa
    model/type: 8014-150U
    sampling information: 1 or 2 strokes
    upper measurement limit: 1200 ppm
    detection limit: approximately 10 ppm
    overall uncertainty: unknown
    method reference: on-site air secondary (manufacturer)

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