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Isopropyl Alcohol

General Description

Synonyms: Isopropanol; IPA; 2-Propanol; sec-Propyl alcohol

OSHA IMIS code: 1560

CAS number: 67-63-0

Exposure Limits and Health Effects (Updated September 6, 2012)

Standard Set By Exposure Limit Health Effect Codes -- Health Effects and Target Organs
OSHA PEL - General Industry
See 29 CFR 1910.1000 Table Z-1
400 ppm (980 mg/m3) TWA
HE8 -- narcosis
HE16 -- mild eye, nose, and throat irritation
OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A
400 ppm (980 mg/m3) TWA
HE8 -- narcosis
HE16 -- mild eye, nose, and throat irritation
OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z - Shipyards
400 ppm (980 mg/m3) TWA
HE8 -- narcosis
HE16 -- mild eye, nose, and throat irritation
NIOSH REL 400 ppm (980 mg/m3) TWA
500 ppm (1,225 mg/m3) STEL
HE7 -- drowsiness, headache, incoordination
HE8 -- unconsciousness
HE16 -- mild eye, nose, and throat irritation
ACGIH TLV® (2001) 200 ppm (491 mg/m3) TWA
400 ppm (984 mg/m3) STEL
A4
BEI®
HE7 -- central nervous system effects (changes in postural sway)
HE16 -- mild eye, nose, and throat irritation
CAL/OSHA PELs 400 ppm (980 mg/m3) TWA
500 ppm (1,225 mg/m3) STEL
 

Carcinogenic classification:

EPA Inhalation Reference Concentration (RfC): Not established

ATSDR Inhalation Minimal Risk Levels (MRLs): Not established

NIOSH IDLH concentration: 2,000 ppm (10% LEL)

Notes on other potential health effects and hazards:

  1. Small differences reported between men and women in the toxicokinetics of inhaled isopropyl alcohol and its major metabolite, acetone, are largely due to sex differences in body weight and percent body fat (Ernstgård et al. 2003).
  2. Susceptible populations include people with preexisting skin disorders and impaired pulmonary function (NIOSH 1978).
  3. Isopropyl alcohol may cause allergic contact dermatitis (Garcia-Gavin et al. 2011).

Partial reference list:

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Isopropanol. 2016.
  • Ernstgård, L., Sjögren, B., Warholm, M. and Johanson, G.: Sex differences in the toxicokinetics of inhaled solvent vapors in humans. 2. 2-propanol. Toxicol. Appl. Pharmacol. 193(2): 158-167, 2003.
  • Garcia-Gavin, J., Lissens, R., Timmermans, A., Goossens, A.: Allergic contact dermatitis caused by isopropyl alcohol: a missed allergen?. Contact Dermatitis. 65(2):101-106, 2011.
  • NIOSH: Criteria for a Recommended StandardOccupational Exposure to Isopropyl Alcohol. March 1976.
  • NIOSH: Occupational Health Guideline for Isopropyl Alcohol. September 1978.
  • NIOSH/CEC/IPCS: International Chemical Safety CardsIsopropyl Alcohol. March 23, 1999.

Chemical Sampling Information

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