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Chemical Sampling Information (CSI)
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General Description

Synonyms: Hydrazine, anhydrous

OSHA IMIS Code Number: 1390

Chemical Abstracts Service (CAS) Registry Number: 302-01-2

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: MU7175000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2029 132 (anhydrous); 3293 152 (≤37% solution); 2030 153 (37-64% solution); 2029 132 (>64% solution)

NIOSH Pocket Guide to Chemical Hazards, Hydrazine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Table Z-1 - 1 ppm, 1.3 mg/m3; Skin

Maritime: 29 CFR 1915.1000 Table Z-Shipyards - 1 ppm, 1.3 mg/m3; Skin

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.01 ppm TWA; Skin; Appendix A3 (Confirmed Animal Carcinogen with Unknown Relevance to Humans)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.03 ppm, 0.04 mg/m3 Ceiling (120 Minutes); Appendix A - Potential Occupational Carcinogen

Health Factors

Carcinogenic Classification:

National Toxicology Program (NTP) carcinogenic classification: Reasonably anticipated to be human carcinogen [152 KB PDF, 3 pages]

International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, possibly carcinogenic to humans [83 KB PDF, 23 pages]

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 50 ppm

Potential Symptoms: Eye, nose, throat irritation; temporary blindness; dizziness; nausea; dermatitis; skin, eye burns; malar rash, photosensitivity, antinuclear antibody, antibody to nDNA (one case); coma (one case); (carcinogenic); In animals: bronchitis, pulmonary edema; liver, kidney damage; convulsions

Health Effects: Irritation-Respiratory tract-Marked (HE14); Cumulative organ damage (HE3); Mutagen (HE2)

Affected Organs: CNS, respiratory system, skin, eyes

Date Last Revised: 05/29/03

Literature Basis:

  • U.S. Environmental Protection Agency, Technology Transfer Network Air Toxics Website, Hydrazine (coma and other symptoms).
  • Reidenberg, M.M., Durant, P.J., Harris, R.A., De Boccardo, G., Lahita, R. and Stenzel, K.H.: Lupus erythematosus-like disease due to hydrazine. Am. J. Med. 75: 365-370, 1983 (malar rash, photosensitivity, antinuclear antibody, antibody to nDNA).
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:

  • sampling media: Two Coated Glass Fiber Filters (37 mm) in 3 piece cassette. Coating is Sulfuric Acid.
    maximum volume: 240 Liters   
    maximum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV
    method reference: OSHA Manual of Analytical Methods (OSHA 108)
    method classification: Fully Validated
    note: The two filters are separated by the ring section of the 3 piece cassette, thereby, providing a backup portion to the sampling train.

On-Site Sampling Techniques/Methods:

  • device: Detector Tube
    manufacturer: AUER/MSA
    model/type: Hydrazine-0.5, AUER P/N 5086-832
    sampling information: follow manufacturer's instructions
    upper measurement limit: 3200 ppm
    detection limit: approx. 20 ppm
    overall uncertainty: unknown
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Dräger
    model/type: Hydrazine 0.2/a, order no. 67 33121
    sampling information: 10 or 20 strokes
    upper measurement limit: 10 ppm
    detection limit: approx. 0.1 ppm
    overall uncertainty: 25%
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Dräger
    model/type: Hydrazine 0.25/a, order no. CH 31801
    sampling information: 10 or 20 strokes
    upper measurement limit: 5 ppm
    detection limit: approx. 0.05 ppm
    overall uncertainty: 16%
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Gastec
    model/type: 185
    sampling information: 5 or 10 strokes
    upper measurement limit: 2.0 ppm
    detection limit: 0.01 ppm
    overall uncertainty: 16% for 0.1 to 0.5 ppm, 8% for 0.5 to 2 ppm
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Matheson-Kitagawa
    model/type: 8014-219S
    sampling information: follow manufacturer's instructions
    upper measurement limit: 10 ppm
    detection limit: approx. 0.1 ppm
    overall uncertainty: unknown
    method reference: on-site air secondary (manufacturer)

Bulk Method: Limit the amount of bulk submitted to one gram or one mL.

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