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Hexamethylene Diisocyanate

General Description

Synonyms: 1,6-Diisocyanatohexane; HDI; Hexamethylene-1,6-diisocyanate; 1,6-Hexamethylene diisocyanate; HMDI; Desmodur N

OSHA IMIS code: 1377

CAS number: 822-06-0; 11142-52-2

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method:
  • glass fiber filter (37 mm open face) coated with 1.0 mg 1-(2-pyridyl) piperazine
  • maximum volume: 15 L
  • maximum flow rate: 1.0 L/min
  • current analytical method: high performance liquid chromatography; HPLC/UV/FLU
  • analytical solvent: (90:10) acetonitrile:dimethylsulfoxide
  • method reference: OSHA 42 (fully validated)
  • note: OSHA personnel may obtain filters from the OSHA-Salt Lake Technical Center and refrigerate until use.
Bulk Method:
  • Limit the amount of bulk submitted to 1 g or 1 mL.

Exposure Limits and Health Effects (Updated September 6, 2012)

Standard Set By Exposure Limit Health Effect Codes -- Health Effects and Target Organs
OSHA PEL
Not established  
NIOSH REL 0.005 ppm (0.035 mg/m3) TWA
0.020 ppm (0.140 mg/m3) Ceiling (10 minutes)
HE9 -- sensitization
HE11 -- upper respiratory tract irritation, decrease in respiratory function
ACGIH TLV® (1985) 0.005 ppm (0.034 mg/m3) TWA HE9 -- asthmatic/respiratory sensitization-like responses
HE14 -- eye, nose, and throat irritation
CAL/OSHA PELs 0.005 ppm (0.034 mg/m3) TWA HE9 -- asthmatic/respiratory sensitization-like responses
HE14 -- eye, nose, and throat irritation

Carcinogenic classification:

  • NTP: Not listed
  • IARC: Not listed
  • EPA: Not listed

EPA Inhalation Reference Concentration (RfC): 1 x 10-5 mg/m3

ATSDR Inhalation Minimal Risk Levels (MRLs): 0.00003 ppm (intermediate); 0.00001 ppm (chronic)

NIOSH IDLH concentration: Not established

Notes on other potential health effects and hazards:

  1. Contact with hexmethylene diisocyante can irritate and burn the eyes and skin. Skin contact may cause blisters. Eye contact may cause corneal damage. Exposure can cause headache, nausea, vomiting, and irritability. High levels of exposure can irritate the lungs and cause coughing and/or shortness of breath. Long-term exposure may cause skin sensitization and an allergic response with itching and skin rash. After an allergy develops, future exposure can result in cough, wheezing, and shortness of breath (Pohanish 2002).

Partial reference list:

Chemical Sampling Information

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