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Chemical Sampling Information (CSI)
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General Description

Synonyms: 1,6-Diisocyanatohexane; HDI; Hexamethylene-1,6-diisocyanate; 1,6-Hexamethylene diisocyanate; HMDI; Desmodur N

OSHA IMIS Code Number: 1377

Chemical Abstracts Service (CAS) Registry Number: 822-06-0

Other Chemical Abstracts Service (CAS) Registry Number: 11142-52-2

NIOSH Registry of Toxic Effects (RTECS) Identification Number: MO1740000

Department of Transportation Regulation Number (49 CFR 172.101) 2012 Emergency Response Guidebook [4 MB PDF, 392 pages]: 2281 156

NIOSH Pocket Guide to Chemical Hazards - Hexamethylene Diisocyanate: Physical description, chemical properties, potentially hazardous incompatibilities, and more

U.S. Environmental Protection Agency (EPA) Hazard Summary - Hexamethylene Diisocyanate: Uses, sources and potential exposure, acute and chronic health hazard information, and more

Exposure Limits and Health Effects

Exposure Limit

Limit Values

HE Codes

Health Factors and Target Organs

OSHA Permissible Exposure Limit (PEL)

Not established

 

 

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL)

0.005 ppm
(0.035 mg/m3) TWA

0.020 ppm
(0.140 mg/m3) Ceiling
(10 minutes)

HE9

Sensitization

HE11

Upper respiratory tract irritation, decrease in respiratory function

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2001)

0.005 ppm
(0.034 mg/m3) TWA 

HE9

Asthmatic/respiratory sensitization-like responses

HE14

Eye, nose, and throat irritation

CAL/OSHA PELs

0.005 ppm
(0.034 mg/m3) TWA

HE9

Asthmatic/respiratory sensitization-like responses

HE14

Eye, nose, and throat irritation

National Toxicology Program (NTP) carcinogenic classification: Not listed

International Agency for Research on Cancer (IARC) carcinogenic classification: Not listed

EPA carcinogenic classification: Not listed

EPA Inhalation Reference Concentration (RfC): 1 x 10-5 mg/m3

Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): 0.00003 ppm (intermediate); 0.00001 ppm (chronic)

NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: Not listed

Notes on Other Potential Health Effects

  1. Contact with hexmethylene diisocyante can irritate and burn the eyes and skin. Skin contact may cause blisters. Eye contact may cause corneal damage. Exposure can cause headache, nausea, vomiting, and irritability. High levels of exposure can irritate the lungs and cause coughing and/or shortness of breath. Long-term exposure may cause skin sensitization and an allergic response with itching and skin rash. After an allergy develops, future exposure can result in cough, wheezing, and shortness of breath (Pohanish 2002).

Date Last Revised: 9/6/2012

Literature Basis

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:

  • sampling media: Glass Fiber Filter (37 mm open face) coated with 1.0 mg 1-(2-pyridyl) piperazine
    analytical solvent: (90:10) Acetonitrile: Dimethylsulfoxide
    maximum volume: 15 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV/FLU
    method reference: OSHA Manual of Analytical Methods (OSHA 42)
    method classification: Fully Validated
    note: OSHA personnel may obtain filters from SLTC and refrigerate until use.

Bulk method: Limit the amount of bulk submitted to one gram or one mL.

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