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Glutaraldehyde

General Description

Synonyms: Glutaric dialdehyde; 1,5-Pentanedial

OSHA IMIS code: 1361

CAS number: 111-30-8

Chemical description and physical properties:

  • varies depending on specific compound

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method:
  • two coated glass fiber filters (open face) in one cassette separated by a spacer. The filters are coated with 2,4-Dinitrophenylhydrazine (DNPH) and phosphoric acid.
  • minimum time: 15 min 
  • maximum flow rate: 1.0 L/min (Ceiling)
  • current analytical method: high performance liquid chromatography; HPLC/UV
  • analytical solvent: acetonitrile
  • method reference: OSHA 64 (fully validated)
  • note: Samples must be kept at reduced temperature and shipped to lab cold.

Exposure Limits and Health Effects (Updated September 6, 2012)

Standard Set By Exposure Limit Health Effect Codes -- Health Effects and Target Organs
OSHA PEL Not established
NIOSH REL 0.2 ppm (0.8 mg/m3) Ceiling HE14 -- eye, nose, and throat irritation
ACGIH TLV® (1998) 0.05 ppm (0.2 mg/m3) Ceiling
dermal sensitizer (DSEN), respiratory sensitizer (RSEN)
A4
HE14 -- nose, throat, eye, and skin irritation; skin sensitization and contact dermatitis
CAL/OSHA PELs 0.05 ppm (0.2 mg/m3) Ceiling HE9 -- respiratory sensitization, allergic sensitization, asthmatic sensitization

Carcinogenic classification:

  • NTP: Not listed
  • IARC: Not listed
  • EPA: Not listed

EPA Inhalation Reference Concentration (RfC): Not established

ATSDR Inhalation Minimal Risk Levels (MRLs): Not established

NIOSH IDLH concentration: Not established

Notes on other potential health effects and hazards:

  1. Patch testing indicated an 8-fold incidence of allergy to glutaraldehyde among health-care workers compared with that of non-health-care working peers (Shaffer and Delsito 2000).
  2. Even though glutaraldehyde has been extensively tested for genetic activity in vitro and in vivo, the results disagree (Zeiger et al. 2005).
  3. NIOSH assigned glutaraldehyde a "SK: DIR (COR)-SEN" skin notation (skin corrosion and skin sensitization) based on sufficient human and animal data (NIOSH 2011).
  4. The ACGIH TLV was established in 1997. The CalOSHA PEL was established in 2006 based on the documentation for the TLV.

Partial reference list:

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Glutaraldehyde. 2016.
  • California Occupational Safety & Health Standards Board: Initial and Final Statement of Reasons. July 6, 2006.
  • NIOSH: Skin Notation Profiles - Glutaraldehyde. April 2011.
  • NIOSH: Recommendations for Occupational Safety and Health - Compendium of Policy Documents and Statements. Cincinnati, OH: U.S. Department of Health and Human Services (DHHS). NIOSH Publication No. 92-100. (1992).
  • NIOSH/CEC/IPCS: International Chemical Safety CardsGlutaraldehyde. December 4, 2000.
  • Shaffer, M.P. and Delsito, D.V.: Allergic contact dermatitis from glutaraldehyde in health-care workers. Contact Dermatitis 43(3): 150-156, 2000.
  • Zeiger E, Gollapudi B, Spencer P: Genetic toxicity and carcinogenicity studies of glutaraldehyde—a review. Mutat Res. 589(2):136-51. March 2005.

Chemical Sampling Information

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