- Chemical Sampling Information
Synonyms: Glutaric dialdehyde; 1,5-Pentanedial
OSHA IMIS code: 1361
CAS number: 111-30-8
Chemical description and physical properties:
- varies depending on specific compound
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method:
- two coated glass fiber filters (open face) in one cassette separated by a spacer. The filters are coated with 2,4-Dinitrophenylhydrazine (DNPH) and phosphoric acid.
- minimum time: 15 min
- maximum flow rate: 1.0 L/min (Ceiling)
- current analytical method: high performance liquid chromatography; HPLC/UV
- analytical solvent: acetonitrile
- method reference: OSHA 64 (fully validated)
- note: Samples must be kept at reduced temperature and shipped to lab cold.
Exposure Limits and Health Effects (Updated September 6, 2012)
|Standard Set By||Exposure Limit||Health Effect Codes -- Health Effects and Target Organs|
|OSHA PEL||Not established|
|NIOSH REL||0.2 ppm (0.8 mg/m3) Ceiling||HE14 -- eye, nose, and throat irritation|
|ACGIH TLV® (1998)||0.05 ppm (0.2 mg/m3) Ceiling
dermal sensitizer (DSEN), respiratory sensitizer (RSEN)
|HE14 -- nose, throat, eye, and skin irritation; skin sensitization and contact dermatitis|
|CAL/OSHA PELs||0.05 ppm (0.2 mg/m3) Ceiling||HE9 -- respiratory sensitization, allergic sensitization, asthmatic sensitization|
- NTP: Not listed
- IARC: Not listed
- EPA: Not listed
EPA Inhalation Reference Concentration (RfC): Not established
ATSDR Inhalation Minimal Risk Levels (MRLs): Not established
NIOSH IDLH concentration: Not established
Notes on other potential health effects and hazards:
- Patch testing indicated an 8-fold incidence of allergy to glutaraldehyde among health-care workers compared with that of non-health-care working peers (Shaffer and Delsito 2000).
- Even though glutaraldehyde has been extensively tested for genetic activity in vitro and in vivo, the results disagree (Zeiger et al. 2005).
- NIOSH assigned glutaraldehyde a "SK: DIR (COR)-SEN" skin notation (skin corrosion and skin sensitization) based on sufficient human and animal data (NIOSH 2011).
- The ACGIH TLV was established in 1997. The CalOSHA PEL was established in 2006 based on the documentation for the TLV.
Partial reference list:
- ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Glutaraldehyde. 2016.
- California Occupational Safety & Health Standards Board: Initial and Final Statement of Reasons. July 6, 2006.
- NIOSH: Skin Notation Profiles - Glutaraldehyde. April 2011.
- NIOSH: Recommendations for Occupational Safety and Health - Compendium of Policy Documents and Statements. Cincinnati, OH: U.S. Department of Health and Human Services (DHHS). NIOSH Publication No. 92-100. (1992).
- NIOSH/CEC/IPCS: International Chemical Safety Cards - Glutaraldehyde. December 4, 2000.
- Shaffer, M.P. and Delsito, D.V.: Allergic contact dermatitis from glutaraldehyde in health-care workers. Contact Dermatitis 43(3): 150-156, 2000.
- Zeiger E, Gollapudi B, Spencer P: Genetic toxicity and carcinogenicity studies of glutaraldehyde—a review. Mutat Res. 589(2):136-51. March 2005.
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