- Synonyms: 2-Furylmethanol; 2-Hydroxymethylfuran
- OSHA IMIS Code Number: 1330
- Chemical Abstracts Service (CAS) Registry Number: 98-00-0
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: LU9100000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 2874 153
- NIOSH Pocket Guide to Chemical Hazards, Furfuryl alcohol: chemical description, physical properties, potentially hazardous incompatibilities, and more
- OSHA Permissible Exposure Limit (PEL):
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2017): 0.2 ppm TWA; Skin; A3
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 10 ppm (40 mg/m3) TWA; 15 ppm (60 mg/m3) STEL; Skin
- NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 75 ppm
- Potential Symptoms: Irritation of eyes, mucous membranes; dizziness; nausea, vomiting, diarrhea; diuresis; headache; sore throat, cough, shortness of breath, wheezing, respiratory depression; INGES. ACUTE: Burning sensation, headache, nausea, unconsciousness
- Health Effects: Irritation- Eyes, Nose, Throat, Skin ---Marked (HE14); CNS effects (HE7)
- Affected Organs: Eyes, skin, respiratory system
- Furfuryl alcohol is a flavoring agent (Flavor and Extract Manufacturers Association number 2491; Joint FAO/WHO Expert Committee on Food Additives number 451), as well as a widely used industrial chemical in, for example, the manufacture of furan resins.
- Two-year rodent carcinogenicity studies by NTP with inhalation of furfuryl alcohol concentrations up to 32 ppm (i.e., below OSHA's PEL) 6 hours/day, 5 days/week, indicated some evidence of carcinogenicity in male rats (nasal) and equivocal evidence of carcinogenicity in female rats (nasal and renal). Non-neoplastic nasal lesions were also observed in rats and mice, as well as nephropathy in rats and male mice; and corneal degeneration in female mice.
- Rats given radiolabeled furfuryl alcohol (in corn oil) by oral gavage excreted most of the radioactivity in the urine. The major urinary metabolite (about ¾ of the dose) was the glycine conjugate of furoic acid, furoylglycine.
- Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Furfuryl alcohol.
- International Chemical Safety Cards (WHO/IPCS/ILO): Furfuryl Alcohol.
- National Toxicology Program: NTP Study Report TR-482 (Abstract). Toxicology and carcinogenesis studies of furfuryl alcohol (CAS No. 98-00-0) in F344/N rats and B6C3F1 mice (inhalation studies).
- Nomier, A.A., Silveira, D.M., McComish, M.F. and Chadwick, M.: Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Drug. Metab. Dispos. 20(2): 198-204, 1992.
- Pohanish, R.P. (editor): Furfuryl Alcohol. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1198-1199.
- Date Last Revised: 11/13/2006
Monitoring Methods used by OSHA
Primary Laboratory Sampling/Analytical Method (SLC1):
- Porapak Q Tube (150/75 mg sections, 50/80 mesh)
- analytical solvent: Acetone
- maximum volume: 25 Liters
- maximum flow rate: 0.05 L/min (TWA)
- minimum volume: 0.75 Liters
- maximum flow rate: 0.05 L/min (STEL)
- current analytical method: Gas Chromatography; GC/FID
- method reference: NIOSH Analytical Method (NIOSH 2505)
- method classification: Fully Validated
** All Trademarks are the property of their respective owners.