Synonyms: 2-Furylmethanol; 2-Hydroxymethylfuran
OSHA IMIS Code Number: 1330
Chemical Abstracts Service (CAS) Registry Number: 98-00-0
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: LU9100000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2874 153
NIOSH Pocket Guide to Chemical Hazards, Furfuryl alcohol: chemical description, physical properties, potentially hazardous incompatibilities, and more
OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Table Z-1 -- 50 ppm, 200 mg/m3 TWA
Construction Industry: 29 CFR 1926.55 Appendix A -- 50 ppm, 200 mg/m3 TWA
Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 50 ppm, 200 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 10 ppm, 40 mg/m3 TWA; 15 ppm, 60 mg/m3 STEL; Skin
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 10 ppm, 40 mg/m3 TWA; 15 ppm, 60 mg/m3 STEL; Skin
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 75 ppm
Potential Symptoms: Irritation of eyes, mucous membranes; dizziness; nausea, vomiting, diarrhea; diuresis; headache; sore throat, cough, shortness of breath, wheezing, respiratory depression; INGES. ACUTE: Burning sensation, headache, nausea, unconsciousness
Health Effects: Irritation- Eyes, Nose, Throat, Skin ---Marked (HE14); CNS effects (HE7)
Affected Organs: Eyes, skin, respiratory system
- Furfuryl alcohol is a flavoring agent (Flavor and Extract Manufacturers Association number 2491; Joint FAO/WHO Expert Committee on Food Additives number 451), as well as a widely used industrial chemical in, for example, the manufacture of furan resins.
- Two-year rodent carcinogenicity studies by NTP with inhalation of furfuryl alcohol concentrations up to 32 ppm (i.e., below OSHA's PEL) 6 hours/day, 5 days/week, indicated some evidence of carcinogenicity in male rats (nasal) and equivocal evidence of carcinogenicity in female rats (nasal and renal). Non-neoplastic nasal lesions were also observed in rats and mice, as well as nephropathy in rats and male mice; and corneal degeneration in female mice.
- Rats given radiolabeled furfuryl alcohol (in corn oil) by oral gavage excreted most of the radioactivity in the urine. The major urinary metabolite (about ¾ of the dose) was the glycine conjugate of furoic acid, furoylglycine.
- NIOSH Pocket Guide to Chemical Hazards: Furfuryl alcohol.
- International Chemical Safety Cards (WHO/IPCS/ILO): Furfuryl Alcohol.
- National Toxicology Program: NTP Study Report TR-482 (Abstract). Toxicology and carcinogenesis studies of furfuryl alcohol (CAS No. 98-00-0) in F344/N rats and B6C3F1 mice (inhalation studies).
- Nomier, A.A., Silveira, D.M., McComish, M.F. and Chadwick, M.: Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Drug. Metab. Dispos. 20(2): 198-204, 1992.
- Pohanish, R.P. (editor): Furfuryl Alcohol. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1198-1199.
Date Last Revised: 11/13/2006
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Porapak Q Tube (150/75 mg sections, 50/80 mesh)
analytical solvent: Acetone
maximum volume: 25 Liters
maximum flow rate: 0.05 L/min (TWA)
maximum volume: 0.75 Liters
maximum flow rate: 0.05 L/min (STEL)
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 2505 [21 KB PDF, 4 pages])
method classification: Fully Validated
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