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Chemical Sampling Information (CSI)
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General Description

Synonyms: Cellosolve® acetate; Cellosolve acetate; EGEEA; Ethylene glycol monoethyl ether acetate; Glycol monoethyl ether acetate

OSHA IMIS Code Number: 1037

Chemical Abstracts Service (CAS) Registry Number: 111-15-9

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KK8225000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1172 129

NIOSH Pocket Guide to Chemical Hazards, 2-Ethoxyethyl acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Table Z-1 -- 100 ppm, 540 mg/m3 TWA; Skin

Construction Industry: 29 CFR 1926.55 Appendix A -- 100 ppm, 540 mg/m3 TWA; Skin

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 100 ppm, 540 mg/m3 TWA; Skin

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 27 mg/m3 TWA; Skin; BEI

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.5 ppm, 2.7 mg/m3 TWA; Skin

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 ppm

Potential Symptoms: Irritation of eyes, nose; vomiting; kidney damage; headache, dizziness, drowsiness, paralysis, unconsciousness; in animals: reproductive, teratogenic effects; SKIN ABS; INGES ACUTE: Nausea, vomiting

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); Cumulative Blood Disturbances (HE12) Reproductive hazards---Teratogenesis and other reproductive impairment (HE5)

Affected Organs: Eyes, respiratory system, gastrointestinal tract; reproductive system, hematopoietic system

Notes:

  1. Explosive vapor/air mixtures of 2-ethoxyethyl acetate may be formed at temperatures above 51°C.
  2. Teratogenic effects in rats by inhalation exposure included heart defects and rib malformations. Increased frequencies of visceral and skeletal variants also occurred. A concentration of 600 ppm was lethal to 100% of the offspring of the 9 pregnant rats exposed to this concentration without the dams showing overt toxicity.
  3. 2-Ethoxyethyl acetate is rapidly hydrolyzed to 2-ethoxyethanol, which in turn, is metabolized mainly by alcohol dehydrogenase to 2-ethoxyacetaldehyde and further by aldehyde dehydrogenase to 2-ethoxyacetic acid, metabolites which are thought to be involved in some of the toxic effects.
  4. Studies of occupational exposure have supported in vitro studies indicating significant systemic absorption of 2-ethoxyethyl acetate through the skin, which measured a mean absorption rate of 0.8 mg per cm2 of human skin per hour.
  5. Curve-fitting of 17 occupationally exposed employees for the time course of urinary excretion of the metabolite, 2-ethoxyacetic acid, yielded an excretion half-time of 57 hours, with individual half-times ranging between 25 and 240 hours.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: 2-Ethoxyethyl acetate.
  • International Chemical Safety Cards (WHO/IPCS/ILO): 2-Ethoxyethyl acetate.
  • MMWR: Criteria for a recommended standard: occupational exposure to ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and their acetates. Morbidity and mortality weekly report 41(21): 386, 1992.
  • Dugard, P.H., Walker, M., Mawdsley, S.J. and Scott, R.C.: Absorption of some glycol ethers through human skin in vitro. Environ. Health Perspect. 57: 193-197, 1984.
  • Johnson, W., Jr., Cosmetic Ingredient Review Expert Panel: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. Int. J. Toxicol. 21(Suppl. 1): 9-62, 2002.
  • Nelson, B.K., et al.: Comparative inhalation teratogenicity of four glycol ether solvents and an amino derivative in rats. Environ. Health Perspect. 57: 261-271, 1984.
  • Pohanish, R.P. (editor): 2-Ethoxyethyl Acetate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1037-1039.
  • Söhnlein, B., Letzel, S., Weltle, D., Rüdiger, H.W. and Angerer, J.: Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers. Int. Arch. Occup. Environ. Health 64(7): 479-484, 1993.
  • Stott, W.T. and McKenna, M.J.: Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro. Fundam. Appl. Toxicol. 5(2): 399-404, 1985.
  • Zissu, D.: Experimental study of cutaneous tolerance to glycol ethers. Contact Dermatitis 32(2): 74-77, 1995.

Date Last Revised: 09/20/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (95:5) Methylene Chloride:Methanol
    maximum volume: 10 Liters
    maximum flow rate: 0.1 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 53)
    method classification: Fully Validated
    note: Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory.

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (95:5) Methylene Chloride:Methanol
    maximum volume: 48 Liters
    maximum flow rate: 0.1 L/min (long term)
    maximum volume: 15 Liters
    maximum flow rate: 0.1 L/min (short term)
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 79)
    method classification: Fully Validated
    note: Use these larger maximum volumes to monitor sub-ppm levels. Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory.

Wipe Sampling Method:

  • sampling media: Charcoal pad
    note: Seal in glass vial for shipment.

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