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Chemical Sampling Information (CSI)
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General Description

Synonyms: Cellosolve®; EGEE; Ethylene glycol monoethyl ether

OSHA IMIS Code Number: 1033

Chemical Abstracts Service (CAS) Registry Number: 110-80-5

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KK8050000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1171 127

NIOSH Pocket Guide to Chemical Hazards, 2-Ethoxyethanol: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Table Z-1 -- 200 ppm, 740 mg/m3 TWA; Skin

Construction Industry: 29 CFR 1926.55 Appendix A -- 200 ppm, 740 mg/m3 TWA; Skin

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 200 ppm, 740 mg/m3 TWA; Skin

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 18 mg/m3 TWA; Skin; BEI

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.5 ppm, 1.8 mg/m3 TWA; Skin

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 ppm

Potential Symptoms: In animals: irritation of eyes, respiratory system; blood changes; liver, kidney, lung damage; reproductive, teratogenic effects; SKIN ABS; INGES ACUTE: Abdominal pain, diarrhea, nausea, vomiting

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); Cumulative Blood Disturbances (HE12) Suspect reproductive hazards---Teratogenesis and other reproductive impairment (HE5)

Affected Organs: Eyes, respiratory system, blood, kidneys, liver, reproductive system, hematopoietic system

Notes:

  1. EPA's inhalation reference concentration (daily inhalational exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for 2-ethoxyethanol is 0.2 mg/m3.
  2. 2-Ethoxyethanol is metabolized mainly by alcohol dehydrogenase to ethoxyacetaldehyde and further by aldehyde dehydrogenase to 2-ethoxyacetic acid, metabolites which are thought to be involved in some of the toxic effects.
  3. Studies with human volunteers have demonstrated substantial systemic absorption of 2-ethoxyethanol liquid and vapor through the skin.
  4. The mean half life for the urinary excretion of the metabolite 2-ethoxyacetic acid was reported to be 24 hours after a 4-hour exposure of human volunteers to 2-ethoxyethanol.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: 2-Ethoxyethanol.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Ethylene glycol monoethyl ether.
  • U.S. EPA Integrated Risk Information System: 2-Ethoxyethanol (CASRN 110-80-5).
  • MMWR: Criteria for a recommended standard: occupational exposure to ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and their acetates. Morbidity and mortality weekly report 41(21): 386, 1992.
  • Groeseneken, D., Veulemans, H. and Masschelein, R: Urinary excretion of ethoxyacetic acid after experimental human exposure to ethylene glycol monoethyl ether. Br. J. Ind. Med. 43(9): 615-619, 1986.
  • Johnson, W., Jr., Cosmetic Ingredient Review Expert Panel: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. Int. J. Toxicol. 21(Suppl. 1): 9-62, 2002.
  • Kežić, S., Mahieu, K., Monster, A.C. and de Wolff, F.A.: Dermal absorption of vaporous and liquid 2-methoxyethanol and 2-ethoxyethanol in volunteers. Occup. Environ. Med. 54(1): 38-43, 1997.
  • Pohanish, R.P. (editor): 2-Ethoxyethanol. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1035-1037.
  • Zissu, D.: Experimental study of cutaneous tolerance to glycol ethers. Contact Dermatitis 32(2): 74-77, 1995.

Date Last Revised: 08/09/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (95:5) Methylene Chloride:Methanol
    maximum volume: 10 Liters
    maximum flow rate: 0.1 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 53)
    method classification: Fully Validated
    note: Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory.

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (95:5) Methylene Chloride:Methanol
    maximum volume: 48 Liters
    maximum flow rate: 0.1 L/min (long term)
    maximum volume: 15 Liters
    maximum flow rate: 0.1 L/min (short term)
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 79)
    method classification: Fully Validated
    note: Use these larger maximum volumes to monitor sub-ppm levels. Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory.

Wipe Sampling Method:

  • sampling media: Charcoal pad
    note: Seal in glass vial for shipment.

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