Potential Symptoms: IN MEN: Possible anorexia, nausea, vomiting, edema; feminization (gynecomastia, erectile dysfunction, atrophy of secondary sex organs, oligospermia); IN WOMEN: Breast tension or pain; cervical hypersecretion; menstrual disorders (menorrhagia, metrorrhagia); nausea, headache; fluid retention, hypertension, leg cramps, vision disturbances; endometriosis pain; possible decrease in milk production by lactating mothers
Health Effects: Known human (female) carcinogen (HE2)
Affected Organs: Male and female reproductive systems
Estrone is an OSHA Select carcinogen.
Estrone is synthesized from androstenedione via aromatase (CYP19) and from estradiol by 17-hydroxysteroid dehydrogenase.
Affinities of estrone for the two estrogen receptors, α and β, are approximately ½ and ⅓, respectively, of the affinities of these receptors for estradiol-17β.
Mean serum estrone levels in samples from postmenopausal women of unknown ovarian status were reported to be about half the levels of estrone found in samples from men in the same age range.
No Author: Estrogens, Steroidal (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
de Ronde, W., Hofman, A., Pols, H.A.P. and de Jong, F.H.: A direct approach to the estimation of the origin of oestrogens and androgens in elderly men by comparison with hormone levels in postmenopausal women. Eur. J. Endocrinol. 152(2): 261-268, 2005.
Kuiper, G.G.J.M., et al.: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology138(3): 863-870, 1997.
Loose-Mitchell, D.S. and Stancel, G.M.: Estrogens and Progestins (Chapter 58). In, Goodman & Gilman's The Pharmacological Basis of Therapeutics, 10th Ed. J.G. Hardman, L.E. Limbird and A.G. Gilman, eds. New York: McGraw-Hill, 2001, pp. 1597-1634.
Pohanish, R.P. (editor): Estrone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1025-1027.
Zeleniuch-Jacquotte, A., et al.: Postmenopausal endogenous oestrogens and risk of endometrial cancer: results of a prospective study. Br. J. Cancer84(7): 975-981, 2001.
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