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Chemical Sampling Information (CSI)
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General Description

Synonyms: Aquacrine; Crinovaryl; 1,3,5-Estratriene-3-ol-17-one; Erystogen; 3-Hydroxyestra-1,3,5(10)-trien-17-one; Menagen

OSHA IMIS Code Number: E320

Chemical Abstracts Service (CAS) Registry Number: 53-16-7

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KG8575000

Chemical Description and Physical Properties:
Solid white powder
molecular formula: C18H22O2
molecular weight: 270.37
melting point: 254-256°C
Health Factors

Carcinogenic Classification:
National Toxicology Program (NTP): Known to be a human carcinogen [137 KB PDF, 4 pages] (estrogens, steroidal)
Potential Symptoms: IN MEN: Possible anorexia, nausea, vomiting, edema; feminization (gynecomastia, erectile dysfunction, atrophy of secondary sex organs, oligospermia); IN WOMEN: Breast tension or pain; cervical hypersecretion; menstrual disorders (menorrhagia, metrorrhagia); nausea, headache; fluid retention, hypertension, leg cramps, vision disturbances; endometriosis pain; possible decrease in milk production by lactating mothers

Health Effects: Known human (female) carcinogen (HE2)

Affected Organs: Male and female reproductive systems

Notes:
  1. Estrone is an OSHA Select carcinogen.
  2. Estrone is synthesized from androstenedione via aromatase (CYP19) and from estradiol by 17-hydroxysteroid dehydrogenase.
  3. Affinities of estrone for the two estrogen receptors, α and ß, are approximately 1/2 and 1/3, respectively, of the affinities of these receptors for estradiol-17ß.
  4. Mean serum estrone levels in samples from postmenopausal women of unknown ovarian status were reported to be about half the levels of estrone found in samples from men in the same age range.
Date Last Revised: 03/10/2006

Literature Basis:
  • No Author: Estrogens, Steroidal [137 KB PDF, 4 pages]. Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • de Ronde, W., Hofman, A., Pols, H.A.P. and de Jong, F.H.: A direct approach to the estimation of the origin of oestrogens and androgens in elderly men by comparison with hormone levels in postmenopausal women. Eur. J. Endocrinol. 152(2): 261-268, 2005.
  • Kuiper, G.G.J.M., et al.: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and ß. Endocrinology 138(3): 863-870, 1997.
  • Loose-Mitchell, D.S. and Stancel, G.M.: Estrogens and Progestins (Chapter 58). In, Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 10th Ed. J.G. Hardman, L.E. Limbird and A.G. Gilman, eds. New York: McGraw-Hill, 2001, pp. 1597-1634.
  • Pohanish, R.P. (editor): Estrone. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1025-1027.
  • Zeleniuch-Jacquotte, A., et al.: Postmenopausal endogenous oestrogens and risk of endometrial cancer: results of a prospective study. Br. J. Cancer 84(7): 975-981, 2001.

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • sampling media: Glass Fiber Filter (37 mm) in 3-piece cassette
    analytical solvent: Methanol
    maximum volume: 240 Liters
    maximum flow rate: 1.0 L/min
    maximum time: 240 Minutes
    current analytical method: High Performance Liquid Chromatography; HPLC/UV at 280nm
    method reference: OSHA Analytical Method (OSHA PV2001)
    method classification: Partially Validated
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Page last updated: 03/30/2007

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