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General Description

  • Synonyms: Aquacrine; Crinovaryl; 1,3,5-Estratriene-3-ol-17-one; Erystogen; 3-Hydroxyestra-1,3,5(10)-trien-17-one; Menagen
  • OSHA IMIS Code Number: E320
  • Chemical Abstracts Service (CAS) Registry Number: 53-16-7
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KG8575000
  • Chemical Description and Physical Properties:
    • Solid white powder
    • molecular formula: C18H22O2
    • molecular weight: 270.37
    • melting point: 254-256°C

Health Factors

  • Carcinogenic Classification:
  • Potential Symptoms: IN MEN: Possible anorexia, nausea, vomiting, edema; feminization (gynecomastia, erectile dysfunction, atrophy of secondary sex organs, oligospermia); IN WOMEN: Breast tension or pain; cervical hypersecretion; menstrual disorders (menorrhagia, metrorrhagia); nausea, headache; fluid retention, hypertension, leg cramps, vision disturbances; endometriosis pain; possible decrease in milk production by lactating mothers
  • Health Effects: Known human (female) carcinogen (HE2)
  • Affected Organs: Male and female reproductive systems
  • Notes:
    1. Estrone is an OSHA Select carcinogen.
    2. Estrone is synthesized from androstenedione via aromatase (CYP19) and from estradiol by 17-hydroxysteroid dehydrogenase.
    3. Affinities of estrone for the two estrogen receptors, α and β, are approximately ½ and ⅓, respectively, of the affinities of these receptors for estradiol-17β.
    4. Mean serum estrone levels in samples from postmenopausal women of unknown ovarian status were reported to be about half the levels of estrone found in samples from men in the same age range.
  • Literature Basis:
    • No Author: Estrogens, Steroidal (PDF). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
    • de Ronde, W., Hofman, A., Pols, H.A.P. and de Jong, F.H.: A direct approach to the estimation of the origin of oestrogens and androgens in elderly men by comparison with hormone levels in postmenopausal women. Eur. J. Endocrinol. 152(2): 261-268, 2005.
    • Kuiper, G.G.J.M., et al.: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138(3): 863-870, 1997.
    • Loose-Mitchell, D.S. and Stancel, G.M.: Estrogens and Progestins (Chapter 58). In, Goodman & Gilman's The Pharmacological Basis of Therapeutics, 10th Ed. J.G. Hardman, L.E. Limbird and A.G. Gilman, eds. New York: McGraw-Hill, 2001, pp. 1597-1634.
    • Pohanish, R.P. (editor): Estrone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1025-1027.
    • Zeleniuch-Jacquotte, A., et al.: Postmenopausal endogenous oestrogens and risk of endometrial cancer: results of a prospective study. Br. J. Cancer 84(7): 975-981, 2001.
  • Date Last Revised: 03/10/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Glass Fiber Filter (37 mm) in 3-piece cassette
  • maximum volume: 240 Liters
  • maximum flow rate: 1.0 L/min
  • maximum time: 240 Minutes
  • current analytical method: High Performance Liquid Chromatography; HPLC/UV at 280nm
  • analytical solvent: Methanol
  • method reference: OSHA Analytical Method (OSHA PV2001)
  • method classification: Partially Validated

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