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Synonyms: Methyl Sulfide; Dimethyl Sulphide; Thiobismethane; DMS; Methylthiomethane; 2-Thiapropane; 2-Thiopropane
OSHA IMIS Code Number: D650
Chemical Abstracts Service (CAS) Registry Number: 75-18-3
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: PV5075000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1164 130
Chemical Description and Physical Properties:
flammable, colorless liquid with characteristic odor
molecular weight: 62.14
vapor pressure: 53.2 kPa @ 20°C
molecular formula: C2H6S
boiling point: 37.3°C
melting point: -98°C
flash point: -49°C
Incompatibilities: Reacts violently with oxidants causing fire and explosion hazard
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 10 ppm, 25 mg/m3 TWA
Potential Symptoms: Irritation of eyes and skin; cough, sore throat; nausea; weakness
Health Effects: Irritation-Eyes---Marked (HE14); Irritation-Skin---Mild (HE16)
Affected Organs: Eyes, skin, respiratory system
- OSHA does not have a PEL for dimethyl sulfide.
- Vapor/air mixtures of dimethyl sulfide may be explosive.
- Dimethyl sulfide is listed by the FDA as a synthetic flavoring substance that is permitted for direct addition to food for human consumption (21 CFR 172.515).
- Dimethyl sulfide is a minor metabolite of the amino acid methionine, the drug cysteamine, and dimethylsulfoxide, and it can be measured in breath, blood and urine.
- Hematological health effects of organic sulfide exposure on employees at a pulp and paper plant have been studied, but the role of dimethyl sulfide in these effects is unknown.
- International Chemical Safety Cards (WHO/IPCS/ILO): Dimethylsulphide.
- Blom, H.J., Boers, G.H., van den Elzen, J.P., Gahl, W.A. and Tangerman, A.: Transamination of methionine in humans. Clin. Sci. (Lond.) 76(1): 43-49, 1989.
- Egorin, M.J., Rosen, D.M., Sridhara, R., Sensenbrenner, L. and Cottier-Fox, M.: Plasma concentrations and pharmacokinetics of dimethylsulfoxide and its metabolites in patients undergoing peripheral-blood stem-cell transplants. J. Clin. Oncol. 16(2): 610-615, 1998.
- Gahl, W.A., Ingelfinger, J., Mohan, P., Bernardini, I., Hyman, P.E. and Tangerman, A.: Intravenous cysteamine therapy for nephropathic cystinosis. Pediatr. Res. 38(4): 579-584, 1995.
- Klingberg, J., Beviz, A., Ohlson, C.G. and Tenhunen, R.: Disturbed iron metabolism among workers exposed to organic sulfides in a pulp plant. Scand. J. Work Environ. Health 14(1): 17-20, 1988.
- Pohanish, R.P. (editor): Dimethyl Sulfide. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 941-942.
- Suarez, F.L., Furne, J.K., Springfield, J. and Levitt, M.D.: Morning breath odor: influence of treatments on sulfur gases. J. Dent. Res. 79(10): 1773-1777, 2000.
Date Last Revised: 02/06/2007
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Methylene Chloride
maximum volume: 5 Liters
maximum flow rate: 0.1 L/min
current analytical method: Gas Chromatography; GC/FPD
method reference: OSHA Salt Lake Technical Center In-House Files
method classification: Partially Validated
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