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Synonyms: Dimethyldisulfide; Methyl disulfide
OSHA IMIS Code Number: D651
Chemical Abstracts Service (CAS) Registry Number: 624-92-0
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: JO1927500
Department of Transportation Regulation Number (49 CFR 172.101) and Guide:
Chemical Description and Physical Properties:
liquid with a characteristic odor
molecular weight: 94.2
vapor pressure: 3.8 kPa @ 25°C
molecular formula: C2H6S2
boiling point: 110°C
melting point: -85°C
Incompatibilities: Highly flammable. Reacts violently with oxidants
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.5 ppm, 1.9 mg/m3 TWA; Skin
Potential Symptoms: Irritation of eyes and skin; cough, sore throat; nausea; weakness
Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); Disagreeable odor (HE20)
Affected Organs: Eyes, skin, respiratory system
- OSHA does not have a PEL for dimethyl disulfide, which is one of the volatile compounds identified with human fecal odor.
- Vapor/air mixtures of dimethyl disulfide above 24°C may be explosive.
- Dimethyl disulfide (methyl disulfide) is listed by the FDA as a synthetic flavoring substance that is permitted for direct addition to food for human consumption (21 CFR 172.515), and it occurs naturally in certain foods (e.g., cabbage, brussels sprouts, garlic, onions).
- Hematological health effects of organic sulfide exposure on employees at a pulp and paper plant have been studied, but the role of dimethyl disulfide in these effects is unknown.
- In subchronic inhalational toxicity studies with rats in concentrations of dimethyl disulfide up to 125 ppm (6 hours/ day, 5 days/week for 13 weeks), the NOAEL was 5 ppm in males and 25 ppm in females.
- In 24-hour whole-body exposure studies, the LC50 of dimethyl disulfide in mice was estimated to be 1.5 µl/l of air, which was close to the concentration needed for 100% lethality in cockroaches (1.66 µl/l of air).
- International Chemical Safety Cards (WHO/IPCS/ILO): Dimethyldisulfide.
- Dugravot, S., et al.: Dimethyl disulfide exerts insecticidal neurotoxicity through mitochondrial dysfunction and activation of insect KATP channels. J. Neurophysiol. 90(1): 259-270, 2003.
- Kim, H.Y., et al.: Evaluation of subchronic inhalation toxicity of dimethyl disulfide in rats. Inhal. Toxicol. 18(5): 395-403, 2006.
- Klingberg, J., Beviz, A., Ohlson, C.G. and Tenhunen, R.: Disturbed iron metabolism among workers exposed to organic sulfides in a pulp plant. Scand. J. Work Environ. Health 14(1): 17-20, 1988.
- Moore, J.G., Jessop, L.D. and Osborne, D.N.: Gas-chromatographic and mass-spectrometric analysis of the odor of human feces. Gastroenterology 93(6): 1321-1329, 1987.
- Pohanish, R.P. (editor): Dimethyl Disulfide. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 923-24.
Date Last Revised: 02/15/2007
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Methylene Chloride
maximum volume: 10 Liters
maximum flow rate: 0.1 L/min
current analytical method: Gas Chromatography; GC/FPD
method reference: OSHA Salt Lake Technical Center In-House File
method classification: Partially Validated
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