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Chemical Sampling Information (CSI)
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General Description

Synonyms: Dimethyldisulfide; Methyl disulfide

OSHA IMIS Code Number: D651

Chemical Abstracts Service (CAS) Registry Number: 624-92-0

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: JO1927500

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2381 130

Chemical Description and Physical Properties:

liquid with a characteristic odor
molecular weight: 94.2
vapor pressure: 3.8 kPa @ 25°C
molecular formula: C2H6S2
boiling point: 110°C
melting point: -85°C

Incompatibilities: Highly flammable. Reacts violently with oxidants

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.5 ppm, 1.9 mg/m3 TWA; Skin

Health Factors

Potential Symptoms: Irritation of eyes and skin; cough, sore throat; nausea; weakness

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); Disagreeable odor (HE20)

Affected Organs: Eyes, skin, respiratory system

Notes:

  1. OSHA does not have a PEL for dimethyl disulfide, which is one of the volatile compounds identified with human fecal odor.
  2. Vapor/air mixtures of dimethyl disulfide above 24°C may be explosive.
  3. Dimethyl disulfide (methyl disulfide) is listed by the FDA as a synthetic flavoring substance that is permitted for direct addition to food for human consumption (21 CFR 172.515), and it occurs naturally in certain foods (e.g., cabbage, brussels sprouts, garlic, onions).
  4. Hematological health effects of organic sulfide exposure on employees at a pulp and paper plant have been studied, but the role of dimethyl disulfide in these effects is unknown.
  5. In subchronic inhalational toxicity studies with rats in concentrations of dimethyl disulfide up to 125 ppm (6 hours/ day, 5 days/week for 13 weeks), the NOAEL was 5 ppm in males and 25 ppm in females.
  6. In 24-hour whole-body exposure studies, the LC50 of dimethyl disulfide in mice was estimated to be 1.5 µl/l of air, which was close to the concentration needed for 100% lethality in cockroaches (1.66 µl/l of air).

Literature Basis:

  • International Chemical Safety Cards (WHO/IPCS/ILO): Dimethyldisulfide.
  • Dugravot, S., et al.: Dimethyl disulfide exerts insecticidal neurotoxicity through mitochondrial dysfunction and activation of insect KATP channels. J. Neurophysiol. 90(1): 259-270, 2003.
  • Kim, H.Y., et al.: Evaluation of subchronic inhalation toxicity of dimethyl disulfide in rats. Inhal. Toxicol. 18(5): 395-403, 2006.
  • Klingberg, J., Beviz, A., Ohlson, C.G. and Tenhunen, R.: Disturbed iron metabolism among workers exposed to organic sulfides in a pulp plant. Scand. J. Work Environ. Health 14(1): 17-20, 1988.
  • Moore, J.G., Jessop, L.D. and Osborne, D.N.: Gas-chromatographic and mass-spectrometric analysis of the odor of human feces. Gastroenterology 93(6): 1321-1329, 1987.
  • Pohanish, R.P. (editor): Dimethyl Disulfide. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 923-24.

Date Last Revised: 02/15/2007

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Methylene Chloride
    maximum volume: 10 Liters
    maximum flow rate: 0.1 L/min
    current analytical method: Gas Chromatography; GC/FPD
    method reference: OSHA Salt Lake Technical Center In-House File
    method classification: Partially Validated

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