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General Description

  • Synonyms: Cyclotrimethylenetrinitramine; Hexahydro-1,3,5-trinitro-1,3,5-triazine; Hexahydro-1,3,5-trinitro-s-triazine; RDX; Trimethylenetrinitramine; 1,3,5-Trinitro-1,3,5-triazacyclohexane
  • OSHA IMIS Code Number: 2224
  • IMIS Name History: RDX (Cyclotrimethylene Trinitramine) prior to 9/1/89
  • Chemical Abstracts Service (CAS) Registry Number: 121-82-4
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: XY9450000
  • NIOSH Pocket Guide to Chemical Hazards, Cyclonite: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.5 mg/m3 TWA; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1.5 mg/m3 TWA, 3 mg/m3 STEL; Skin

Health Factors

Environmental Protection Agency (EPA) carcinogenic classification: Group C, possible human carcinogen

  • Potential Symptoms: Irritation of eyes, skin; headache, irritability, lassitude (weakness, exhaustion), tremor, nausea, vomiting, dizziness, confusion, insomnia, convulsions, unconsciousness (postictal coma), postictal amnesia; tachycardia, ventricular premature beats; petechial rash; methemoglobinemia; kidney damage (hypokalemia, metabolic acidosis, proteinuria, glucosuria, myoglobinuria)
  • Health Effects: Irritation-Eyes, Nose, Throat, Skin (intensity unknown); Acute CNS Toxicity (HE7)
  • Affected Organs: Eyes, skin, CNS
  • Notes:
  1. OSHA does not have a PEL for cyclonite, a component of C-4 and some other explosive materials.
  2. Intoxications with cyclonite among military personnel by intentional (but not suicidal) oral abuse (chewing C-4) or by accidental inhalation while using C-4 as a cooking fuel have been reported.
  3. EPA's oral Reference Dose (RfD), the daily oral exposure likely to be without appreciable health risk during a lifetime, is 0.003 mg/kg/day.

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Cyclonite.
  • U.S. EPA Integrated Risk Information System: Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (CASRN 121-82-4).
  • Goldberg, D.J., Green, S.T., Nathwani, D., McMenamin, J., Hamlet, N. and Kennedy, D.H.: RDX intoxication causing seizures and a widespread petechial rash mimicking meningococcaemia. J. R. Soc. Med. 85(3): 181, 1992.
  • Küçükardali, Y., et al.: Accidental oral poisoning caused by RDX (cyclonite): a report of 5 cases. J. Intensive Care Med. 18(1): 42-46, 2003.
  • Pohanish, R.P. (editor): Cyclonite. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 731-732.

Date Last Revised: 04/07/2006

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Glass Fiber Filter (37 mm)
  • analytical solvent: Acetonitrile
  • maximum volume: 120 Liters
  • maximum flow rate: 1.0 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UV
  • method reference: OSHA Analytical Method (OSHA PV2135)
  • method classification: Partially Validated
Bulk Method:
  • Limit the amount of bulk submitted to one gram or one mL.

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