Synonyms: Cyclotrimethylenetrinitramine; Hexahydro-1,3,5-trinitro-1,3,5-triazine; Hexahydro-1,3,5-trinitro-s-triazine; RDX; Trimethylenetrinitramine; 1,3,5-Trinitro-1,3,5-triazacyclohexane
OSHA IMIS Code Number: 2224
IMIS Name History: RDX (Cyclotrimethylene Trinitramine) prior to 9/1/89
Chemical Abstracts Service (CAS) Registry Number: 121-82-4
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: XY9450000
NIOSH Pocket Guide to Chemical Hazards, Cyclonite: chemical description, physical properties, potentially hazardous incompatibilities, and more
OSHA Permissible Exposure Limit (PEL):
Construction Industry: 29 CFR 1926.55 Appendix A -- 1.5 mg/m3 TWA; Skin
Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 1.5 mg/m3 TWA; Skin
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.5 mg/m3 TWA; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1.5 mg/m3 TWA, 3 mg/m3 STEL; Skin
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): Group C, possible human carcinogen
Potential Symptoms: Irritation of eyes, skin; headache, irritability, lassitude (weakness, exhaustion), tremor, nausea, vomiting, dizziness, confusion, insomnia, convulsions, unconsciousness (postictal coma), postictal amnesia; tachycardia, ventricular premature beats; petechial rash; methemoglobinemia; kidney damage (hypokalemia, metabolic acidosis, proteinuria, glucosuria, myoglobinuria)
Health Effects: Irritation-Eyes, Nose, Throat, Skin (intensity unknown); Acute CNS Toxicity (HE7)
Affected Organs: Eyes, skin, CNS
- OSHA does not have a PEL for cyclonite, a component of C-4 and some other explosive materials.
- Intoxications with cyclonite among military personnel by intentional (but not suicidal) oral abuse (chewing C-4) or by accidental inhalation while using C-4 as a cooking fuel have been reported.
- EPA’s oral Reference Dose (RfD), the daily oral exposure likely to be without appreciable health risk during a lifetime, is 0.003 mg/kg/day.
- NIOSH Pocket Guide to Chemical Hazards: Cyclonite.
- U.S. EPA Integrated Risk Information System: Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (CASRN 121-82-4).
- Goldberg, D.J., Green, S.T., Nathwani, D., McMenamin, J., Hamlet, N. and Kennedy, D.H.: RDX intoxication causing seizures and a widespread petechial rash mimicking meningococcaemia. J. R. Soc. Med. 85(3): 181, 1992.
- Küçükardali, Y., et al.: Accidental oral poisoning caused by RDX (cyclonite): a report of 5 cases. J. Intensive Care Med. 18(1): 42-46, 2003.
- Pohanish, R.P. (editor): Cyclonite. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 731-732.
Date Last Revised: 04/07/2006
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Glass Fiber Filter (37 mm)
analytical solvent: Acetonitrile
maximum volume: 120 Liters
maximum flow rate: 1.0 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: OSHA Analytical Method (OSHA PV2135)
method classification: Partially Validated
- Limit the amount of bulk submitted to one gram or one mL.
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