- Synonyms: beta-Mehylacrolein; Propylene aldehyde; Crotonic aldehyde; 2-Butenal
- OSHA IMIS Code Number: 0770
- Chemical Abstracts Service (CAS) Registry Number: 123-73-9; 4170-30-3
- NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: GP9499000
- Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook:131P
- NIOSH Pocket Guide to Chemical Hazards, Crotonaldehyde: chemical description, physical properties, potentially hazardous incompatibilities, and more
- OSHA Permissible Exposure Limit (PEL):
- American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.3 ppm, 0.86 mg/m3 Ceiling; Skin; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
- National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 2 ppm, 6 mg/m3 TWA; Appendix C - Supplementary Exposure Limits (Aldehydes)
- Carcinogenic Classification:
- International Agency for Research on Cancer (IARC): Group 3 - not classifiable as to its carcinogenicity to humans (PDF)
- NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 50 ppm
- Potential Symptoms: Eye, respiratory system irritation; cough, burning sensation, sore throat, labored breathing, pulmonary edema (may be delayed); eye redness, pain, lacrimation, severe deep burns.
- Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Lung edema (HE11)
- Affected Organs: Respiratory system, eyes, skin
- In addition to its various industrial uses, crotonaldehyde is formed in the body as a product of lipid peroxidation and can form adducts with DNA, as well as with lysine and histidine amino acids in proteins.
Date Last Revised: 04/29/2004
- NIOSH Pocket Guide to Chemical Hazards: Crotonaldehyde.
- International Chemical Safety Cards (WHO/IPCS/ILO): Crotonaldehyde.
- Ichihashi, K., Osawa, T., Toyokuni, S. and Uchida, K.: Endogenous formation of protein adducts with carcinogenic Aldehydes: implications for oxidative stress. J. Biol. Chem. 276(26): 23903-23913, 2001.
- Pan, J. and Chung, F.L.: Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. Chem. Res. Toxicol. 15(3): 367-372, 2002.
- Pohanish, R.P. (editor): Crotonaldehyde. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 677-679.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
- Two Coated Glass Fiber Filters (Open Face) in one cassette separated by a spacer. The filters are coated with 2,4-Dinitrophenylhydrazine (DNPH) and Phosphoric Acid.
- analytical solvent: Acetonitrile
- maximum volume: 6 Liters
- maximum flow rate: 0.1 L/min
- current analytical method: High Performance Liquid Chromatography; HPLC/UV
- method reference: OSHA Analytical Method (OSHA 81)
- method classification: Fully Validated
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