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Crotonaldehyde

General Description

  • Synonyms: beta-Mehylacrolein; Propylene aldehyde; Crotonic aldehyde; 2-Butenal
  • OSHA IMIS Code Number: 0770
  • Chemical Abstracts Service (CAS) Registry Number: 123-73-9; 4170-30-3
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: GP9499000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook:131P
  • NIOSH Pocket Guide to Chemical Hazards, Crotonaldehyde: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.3 ppm, 0.86 mg/m3 Ceiling; Skin; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 2 ppm, 6 mg/m3 TWA; Appendix C - Supplementary Exposure Limits (Aldehydes)

Health Factors

  • Carcinogenic Classification:
  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 50 ppm
  • Potential Symptoms: Eye, respiratory system irritation; cough, burning sensation, sore throat, labored breathing, pulmonary edema (may be delayed); eye redness, pain, lacrimation, severe deep burns.
  • Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Lung edema (HE11)
  • Affected Organs: Respiratory system, eyes, skin
  • Notes:
    • In addition to its various industrial uses, crotonaldehyde is formed in the body as a product of lipid peroxidation and can form adducts with DNA, as well as with lysine and histidine amino acids in proteins.

Date Last Revised: 04/29/2004

Literature Basis:

  • NIOSH Pocket Guide to Chemical Hazards: Crotonaldehyde.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Crotonaldehyde.
  • Ichihashi, K., Osawa, T., Toyokuni, S. and Uchida, K.: Endogenous formation of protein adducts with carcinogenic Aldehydes: implications for oxidative stress. J. Biol. Chem. 276(26): 23903-23913, 2001.
  • Pan, J. and Chung, F.L.: Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. Chem. Res. Toxicol. 15(3): 367-372, 2002.
  • Pohanish, R.P. (editor): Crotonaldehyde. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 677-679.

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • Two Coated Glass Fiber Filters (Open Face) in one cassette separated by a spacer. The filters are coated with 2,4-Dinitrophenylhydrazine (DNPH) and Phosphoric Acid.
  • analytical solvent: Acetonitrile
  • maximum volume: 6 Liters
  • maximum flow rate: 0.1 L/min
  • current analytical method: High Performance Liquid Chromatography; HPLC/UV
  • method reference: OSHA Analytical Method (OSHA 81)
  • method classification: Fully Validated

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Index

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