NIOSH Immediately Dangerous To Life or Health Concentration (IDLH):50 ppm
Potential Symptoms: Eye, respiratory system irritation; cough, burning sensation, sore throat, labored breathing, pulmonary edema (may be delayed); eye redness, pain, lacrimation, severe deep burns.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Lung edema (HE11)
Affected Organs: Respiratory system, eyes, skin
In addition to its various industrial uses, crotonaldehyde is formed in the body as a product of lipid peroxidation and can form adducts with DNA, as well as with lysine and histidine amino acids in proteins.
Ichihashi, K., Osawa, T., Toyokuni, S. and Uchida, K.: Endogenous formation of protein adducts with carcinogenic Aldehydes: implications for oxidative stress. J. Biol. Chem.276(26): 23903-23913, 2001.
Pan, J. and Chung, F.L.: Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. Chem. Res. Toxicol.15(3): 367-372, 2002.
Pohanish, R.P. (editor): Crotonaldehyde. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 677-679.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
Two Coated Glass Fiber Filters (Open Face) in one cassette separated by a spacer. The filters are coated with 2,4-Dinitrophenylhydrazine (DNPH) and Phosphoric Acid.
analytical solvent: Acetonitrile
maximum volume: 6 Liters
maximum flow rate: 0.1 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
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