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General Description

  • Synonyms: Benzene, 1-chloro-4-(trifluoromethyl)-; p-Chlorobenzotrifluoride; (p-Chlorophenyl)trifluoromethane; p-(Trifluoromethyl)chlorobenzene; p-Trifluoromethylphenyl chloride, p-Chloro-alpha, alpha, alpha-trifluorotoluene
  • OSHA IMIS Code Number: R249
  • Chemical Abstracts Service (CAS) Registry Number: 98-56-6
  • Other Chemical Abstracts Service (CAS) Registry Number: 92709-16-5

Exposure Limits and Health Effects

Exposure Limit Limit Values HE Codes Health Factors and Target Organs

OSHA Permissible Exposure Limit (PEL)

  • Not established

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL)

  • Not established

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV)

  • Not established


  • Not established
  • National Toxicology Program (NTP) carcinogenic classification: Not listed
  • International Agency for Research on Cancer (IARC) carcinogenic classification: Not listed
  • U.S. Environmental Protection Agency (EPA) carcinogenic classification: Not listed
  • EPA Inhalation Reference Concentration (RfC): Not established
  • Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established
  • NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: Not established
  • Notes on Other Potential Health Effects and Hazards
    1. Exposure may cause irritation to the skin, eyes, and mucous membranes (Pohanish 2008).
    2. In June 2009, the National Toxicology Program developed a Chemical Information Profile for 1-Chloro-4-(trifluoromethyl)benzene [CAS No. 98-56-6] supporting nomination for toxicological evaluation (NTP 2009).
  • Date Last Revised: 9/6/2012
  • Literature Basis:

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • charcoal tube (100/50 mg sections, 20/40 mesh)
  • analytical solvent: Carbon Disulfide/Methanol (99:1)
  • maximum volume: 10 Liters
  • maximum flow rate: 0.2 L/min (TWA)
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: NIOSH Analytical Method (NIOSH 1026 (PDF))
  • method classification: Partially Validated

note: Samples must be refrigerated for shipment to laboratory. Sample stability is 7 days at 25°C; and 30 days at 5°C.

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