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Chemical Sampling Information (CSI)
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General Description

OSHA IMIS Code Number: 0640

Chemical Abstracts Service (CAS) Registry Number: 7782-50-5

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: FO2100000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1017 124

NIOSH Pocket Guide to Chemical Hazards, Chlorine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 1 ppm, 3 mg/m3 Ceiling

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 1 ppm, 3 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.5 ppm, 1.5 mg/m3 TWA; 1 ppm, 2.9 mg/m3 STEL; Appendix A4 (Not Classifiable as a Human Carcinogen)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.5 ppm TWA; 1 ppm STEL

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 10 ppm

Potential Symptoms: Eye, nose, mouth, skin burns; lacrimation; rhinorrhea; coughing, choking; nausea, vomiting; substernal pain; headache; dizziness, syncope; pulmonary edema; persistent airways obstruction, bronchial hyper-responsiveness; hypoxemia; dermatitis; CNS impairment (balance, reaction time, color confusion, visual field performance, blink latency, cognition, verbal recall, adverse mood states); decreased grip strength

Health Effects: Lung injury (HE11); Irritation-Eyes, Nose, Throat, Bronchi, Skin---Marked (HE14); Central Nervous System Disturbances (HE7)

Affected Organs: Respiratory system; CNS


  1. The persistent respiratory symptoms after acute exposure have been called "Reactive airways dysfunction syndrome" (RADS), and unlike occupational asthma, RADS appears to be less responsive to bronchodilator (albuterol) inhalation therapy.

Literature Basis:

  • (persistent respiratory symptoms)
    Bhérer, L., Cushman, R., Courteau, J.P., Quévillon, M., Côté, G., Bourbeau, J., L'Archevêque, J., Cartier, A. and Malo, J.L.: Survey of construction workers repeatedly exposed to chlorine over a three to six month period in a pulpmill. II. Follow up of affected workers by questionnaire, spirometry, and assessment of bronchial responsiveness 18 to 24 months after exposure ended. Occup. Environ. Med. 51(4): 225-228, 1994.
  • (resistance to albuterol)
    Gautrin, D., Boulet, L.P., Boutet, M., Dugas, M., Bhérer, L., L'Archevêque, J., Laviolette, M., Côté, G. and Malo, J.L.: Is reactive airways dysfunction syndrome a variant of occupational asthma? J. Allergy Clin. Immunol. 93(1 Pt. 1): 12-22, 1994.
  • (CNS impairment)
    Kilburn, K.H.: Chlorine-induced damage documented by neurophysiological, neuropsychological, and pulmonary testing. Arch. Environ. Health 55(1): 31-37, 2000.

Date Last Revised: 05/13/2003

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Midget Fritted Glass Bubbler (MFGB) containing Sulfamic Acid solution (0.1%)
    maximum volume: 240 Liters
    maximum flow rate: 1.0 L/min (TWA)
    maximum volume: 15 Liters
    maximum flow rate: 1.0 L/min (STEL or Ceiling)
    current analytical method: Ion Specific Electrode; ISE
    method reference: OSHA Manual of Analytical Methods (OSHA ID-101)
    method classification: Fully Validated
    note: Submit as separate sample. If Chlorine containing compounds (as available Chlorine) are also expected, use a PTFE membrane/polypropylene cassette, followed by a Midget Fritted Glass Bubbler (MFGB) containing 15 mL 0.1% Sulfamic Acid for Chlorine Collection. Sample analyzed for equivalent chlorine levels. After sampling transfer membrane to separate vial containing 5 mL 0.1% Sulfamic acid. Seal and ship to the Salt Lake Technical Center.

On-Site Sampling Techniques/Methods:

  • device: Detector Tube
    manufacturer: Matheson-Kitagawa
    model/type: 8014-109SB
    sampling information: follow manufacturer's instructions
    upper measurement limit: 10 ppm
    detection limit: approx. 0.1 ppm
    overall uncertainty: unknown
    method reference: on-site air secondary (SEI Certified)

    device: Detector Tube
    manufacturer: Gastec
    model/type: 8La
    sampling information: 0.5 to 5 strokes
    upper measurement limit: 16 ppm
    detection limit: 0.05 ppm
    overall uncertainty: 16.4% for 0.5 to 2 ppm, 8.2% for 2 to 8 ppm
    method reference: on-site air secondary (SEI Certified)

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