Chemical Abstracts Service (CAS) Registry Number: 1634-04-4
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number:KN5250000
Chemical Description and Physical Properties:
molecular formula: C5H12O
molecular weight: 88.17
boiling point: 55.2°C
vapor pressure: kPa at 20°C: 27
melting point: -109°C
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 50 ppm TWA; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
Potential Symptoms: Drowsiness, dizziness, headache, weakness, unconsciousness; redness of skin and eyes; Acute ingestion: Nausea, vomiting, abdominal pain; chemical pneumonitis (by aspiration).
Health Effects: Irritation-Eyes, skin---mild (HE16); Nervous system disturbances (HE7); Explosive, flammable (HE18)
Affected Organs: Central nervous system, skin, eyes
MTBE is used as a major gasoline additive (up to 15%) and experimentally for dissolving cholesterol gall stones.
Metabolism of MTBE by hepatic CYP2A6 (which also metabolizes coumarin and nicotine) is strongly inhibited by the drugs, methoxsalen and tranylcypromine.
Systemic exposure can occur via absorption through the skin. Most symptoms claimed for airborne MTBE exposure have not been rigorously documented, as occupational exposure is rarely to the pure compound alone. Its potent odor is recognized at 90-130 ppb.
(absorption; metabolism) Draper, A.J., Madan, A. and Parkinson, A.: Inhibition of coumarin 7-hydroxylase activity in human liver microsomes. Arch. Biolchem. Biophys.341(1): 47-61, 1997.
Prah, J.D., Blount, B., Cardinali, F.L., Ashley, D.L., Leavens, T. and Case, M.W.: The development and testing of a dermal exposure system for pharmacokinetic studies of administered and ambient water contaminants. J. Pharmacol. Toxicol. Methods47(3): 189-195, 2002.
(clinical use) Hellstern, A., et al.: Dissolution of gallbladder stones with methyl tert-butyl ether and stone recurrence: a European survey. Dig. Dis. Sci.43(5): 911-920, 1998.
(general reviews) Borak, J., Pastides, H., Van Ert, M., Russi, M. and Herzstein J.: Exposure to MTBE and acute human health effects: a critical literature review. Human and Ecological Risk Assessment4(1): 177-200, 1998.
All other documents, that are not PDF materials or formatted for the web, are available as Microsoft Office® formats and videos and are noted accordingly. If additional assistance is needed with reading, reviewing or accessing these documents or any figures and illustrations, please also contact OSHA's Directorate of Technical Support and Emergency Management at (202) 693-2300.
**eBooks - EPUB is the most common format for e-Books. If you use a Sony Reader, a Nook, or an iPad you can download the EPUB file format. If you use a Kindle, you can download the MOBI file format.
U.S. Department of Labor | Occupational Safety & Health Administration | 200 Constitution Ave., NW, Washington, DC 20210 Telephone: 800-321-OSHA (6742) | TTY www.OSHA.gov
Thank You for Visiting Our Website
You are exiting the Department of Labor's Web server.
The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.