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Chemical Sampling Information (CSI)
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General Description

Synonyms: Hydrogen arsenide; Arsenic trihydride

OSHA IMIS Code Number: 0270

Chemical Abstracts Service (CAS) Registry Number: 7784-42-1

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: CG6475000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2188 119

NIOSH Pocket Guide to Chemical Hazards, Arsine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 0.05 ppm, 0.2 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 0.05 ppm, 0.2 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.005 ppm, 0.016 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.002 mg/m3 Ceiling (15 min); Potential Carcinogen

Health Factors

Carcinogenic Classification:

International Agency for Research on Cancer (IARC): Arsenic and Arsenic Compounds - Group 1, carcinogenic to humans

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 3 ppm

Potential Symptoms: Headaches; malaise, weakness, dizziness; dyspnea; abdomen and back pain; nausea, vomiting, diarrhea; bronze skin; hematuria (hemoglobin in urine); jaundice, liver enlargement; fever, tachypnea, tachycardia, anemia, hyperkalemia, electrocardiographic changes; peripheral neuropathy (focal anesthesia and paresthesia); agitation, disorientation, hallucinations; (carcinogenic)

Health Effects: Acute Systemic Toxicity - hemolysis, renal failure, heart failure (HE4); Nervous System Disturbances - peripheral nerve degeneration (HE7)

Affected Organs: Blood, kidneys, liver, heart

Literature Basis:

  • Klimecki, W.T. and Carter, D.E.: Arsine toxicity: chemical and mechanistic implications. J. Toxicol. Environ. Health 46 : 399-409, 1995.

Date Last Revised: 05/07/2003

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    maximum volume: 10 Liters
    minimum volume: 1.0 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Atomic Absorption Spectroscopy; AAS/GF
    method reference: NIOSH Manual of Analytical Methods (NIOSH 6001 [22 KB PDF, 4 pages])
    method classification: Fully Validated

On-Site Sampling Techniques/Methods:

  • device: Detector Tube
    manufacturer: Dräger
    model/type: Arsine 0.05/a, order no. CH 25001
    sampling information: 20 strokes
    upper measurement limit: 3.0 ppm
    detection limit: approximately 0.03 ppm
    overall uncertainty: 25-33%
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Matheson-Kitagawa
    model/type: 8014-140SA
    sampling information: follow manufacturer's instructions
    upper measurement limit: 160 ppm
    detection limit: approximately 5 ppm
    overall uncertainty: unknown
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Matheson-Kitagawa
    model/type: 8014-121U
    sampling information: follow manufacturer's instructions
    upper measurement limit: 2.0 ppm
    detection limit: approximately 0.05 ppm
    overall uncertainty: unknown
    method reference: on-site air secondary (manufacturer)

  • device: Detector Tube
    manufacturer: Gastec
    model/type: 19LA
    sampling information: 1 to 10 strokes
    upper measurement limit: 10 ppm
    detection limit: 0.02 ppm
    overall uncertainty: 16.4% for 0.1 to 0.5 ppm, 8.2% for 0.5 to 1.5 ppm
    method reference: on-site air secondary (manufacturer)

  • device: Colorimetric Badge
    manufacturer: K&M Environmental Products
    model/type: SafeAir Arsine Monitor, part no. 382030-50
    sampling information: 0.25 to 12-h exposure
    upper measurement limit: 4.0 ppm for 0.25-h exposure
    detection limit: 2.25 ppb for 8-h exposure
    overall uncertainty: unknown
    method reference: on-site air secondary (manufacturer)

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