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Arsine

General Description

  • Synonyms: Hydrogen arsenide; Arsenic trihydride
  • OSHA IMIS Code Number: 0270
  • Chemical Abstracts Service (CAS) Registry Number: 7784-42-1
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: CG6475000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2188 119
  • NIOSH Pocket Guide to Chemical Hazards, Arsine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.005 ppm, 0.016 mg/m3 TWA
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.002 mg/m3 Ceiling (15 min); Potential Carcinogen

Health Factors

  • Carcinogenic Classification:
    • International Agency for research on Cancer (IARC): Arsenic and Arsenic Compounds - Group 1, carcinogenic to humans
  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 3 ppm
  • Potential Symptoms: Headaches; malaise, weakness, dizziness; dyspnea; abdomen and back pain; nausea, vomiting, diarrhea; bronze skin; hematuria (hemoglobin in urine); jaundice, liver enlargement; fever, tachypnea, tachycardia, anemia, hyperkalemia, electrocardiographic changes; peripheral neuropathy (focal anesthesia and paresthesia); agitation, disorientation, hallucinations; (carcinogenic)
  • Health Effects: Acute Systemic Toxicity - hemolysis, renal failure, heart failure (HE4); Nervous System Disturbances - peripheral nerve degeneration (HE7)
  • Affected Organs: Blood, kidneys, liver, heart
  • Literature Basis:
    • Klimecki, W.T. and Carter, D.E.: Arsine toxicity: chemical and mechanistic implications. J. Toxicol. Environ. Health 46 : 399-409, 1995.
  • Date Last Revised: 05/07/2003

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):
  • Charcoal Tube (100/50 mg sections, 20/40 mesh)
  • maximum volume: 10 Liters
  • minimum volume: 1.0 Liters
  • maximum flow rate: 0.2 L/min
  • current analytical method: Atomic Absorption Spectroscopy; AAS/GF
  • method reference: NIOSH Manual of Analytical Methods (NIOSH 6001 (PDF))
  • method classification: Fully Validated
On-Site Sampling Techniques/Methods:
  • Detector Tube
  • manufacturer: Dräger
  • model/type: Arsine 0.05/a, order no. CH 25001
  • sampling information: 20 strokes
  • upper measurement limit: 3.0 ppm
  • detection limit: approximately 0.03 ppm
  • overall uncertainty: 25-33%
  • method reference: on-site air secondary (manufacturer)
  • Detector Tube
  • manufacturer: Matheson-Kitagawa
  • model/type: 8014-140SA
  • sampling information: follow manufacturer's instructions
  • upper measurement limit: 160 ppm
  • detection limit: approximately 5 ppm
  • overall uncertainty: unknown
  • method reference: on-site air secondary (manufacturer)
  • Detector Tube
  • manufacturer: Matheson-Kitagawa
  • model/type: 8014-121U
  • sampling information: follow manufacturer's instructions
  • upper measurement limit: 2.0 ppm
  • detection limit: approximately 0.05 ppm
  • overall uncertainty: unknown
  • method reference: on-site air secondary (manufacturer)
  • Detector Tube
  • manufacturer: Gastec
  • model/type: 19LA
  • sampling information: 1 to 10 strokes
  • upper measurement limit: 10ppm
  • detection limit: 0.02 ppm
  • overall uncertainty: 16.4% for 0.1 to 0.5 ppm, 8.2% for 0.5 to 1.5 ppm
  • method reference: on-site air secondary (manufacturer)
  • Colorimetric Badge
  • manufacturer: K&M Environmental Products
  • model/type: SafeAir Arsine Monitor, part no. 382030-50
  • sampling information: 0.25 to 12-h exposure
  • upper measurement limit: 4.0 ppm for 0.25-h exposure
  • detection limit: 2.25 ppb for 8-h exposure
  • overall uncertainty: unknown
  • method reference: on-site air secondary (manufacturer)

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