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General Description

  • Synonyms: Aminobenzene; Phenylamine; Aniline oil.
  • OSHA IMIS Code Number: 0220
  • Chemical Abstracts Service (CAS) Registry Number: 62-53-3
  • NIOSH, Registry of Toxic Effects (RTECS) Identification Number: BW6650000
  • Department of Transportation Regulation Number (49 CFR 172.101) and Emergency Response Guidebook: 1547 153
  • NIOSH Pocket Guide to Chemical Hazards, Aniline: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

  • OSHA Permissible Exposure Limit (PEL):
  • American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 2 ppm, 7.6 mg/m3 TWA; Skin; Appendix A3, Confirmed Animal Carcinogen with Unknown Relevance to Humans; BEI
  • National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Appendix A - NIOSH Potential Occupational Carcinogens

Health Factors

  • Carcinogenic Classification:
    • International Agency for Research on Cancer (IARC) carcinogenic classification: Group 3, not classifiable as to its carcinogenicity to humans
  • NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 100 ppm
  • Potential Symptoms: Headache; weakness; lethargy; dizziness; drowsiness; confusion, disorientation; unconsciousness; ataxia; eye irritation; respiratory irritation (dryness of throat, coughing, wheezing); dyspnea on effort; tachycardia; cyanosis, jaundice; nausea; sometimes vomiting, ringing in the ears; anorexia, weight loss, anemia; skin lesions; symptoms of bladder cancer (painful urination, blood in the urine, lumps in groin or lower abdomen, pain in lower abdomen or back).
  • Health Effects: Hematologic (Blood) Disturbances---Methmoglobinemia (HE13) Acute Toxicity--- short-term high hazard effects (HE4); Suspect carcinogen (bladder cancer) (HE2); LD50 (oral, rat) 440 mg/kg.
  • Affected Organs: Blood, cardiovascular system, liver, kidneys, eyes, respiratory system, skin.
  • Notes: Interacts with cytochrome P450 2E1 (both as substrate and inhibitor of other substrates), so there is a potential for interaction with ethanol and acetaminophen.
  • Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: Aniline.
    • International Chemical Safety Cards (WHO/IPCS/ILO): Aniline.
    • Klotz, U. and Ammon, E.: Clinical and toxicological consequences of the inductive potential of ethanol. Eur. J. Clin. Pharmacol. 54(1): 7-12, 1998.
    • Pohanish, R.P. (editor): Aniline. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 207-210.
  • Date Last Revised: 12/15/2003

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method:
  • Coated XAD-7 Tube (80/40 mg sections) Coating is 10% Phosphoric Acid.
  • analytical solvent: 0.2 N NH4OH in Methanol
  • maximum volume: 30 Liters
  • maximum flow rate: 0.2 L/min
  • current analytical method: Gas Chromatography; GC/FID
  • method reference: OSHA Manual of Analytical Methods (OSHA PV2079)
  • method classification: Partially Validated
On-Site Sampling Techniques/Methods:
  • Detector Tube
  • manufacturer: Dräger
  • model/type: Aniline 0.5/a, order no. 81 01711
  • sampling information: 20 strokes
  • upper measurement limit: 10 ppm
  • detection limit: approximately 0.2 ppm
  • overall uncertainty: approximately 25%
  • method reference: on-site air secondary (manufacturer)
  • Detector Tube
  • manufacturer: Gastec
  • model/type: 181
  • sampling information: 2 to 5 strokes
  • upper measurement limit: 60 ppm
  • detection limit: 0.25 ppm
  • overall uncertainty: 16% for 2.5 to 10 ppm, 8% for 10 to 30 ppm
  • method reference: on-site air secondary (manufacturer)
  • Detector Tube
  • manufacturer: Matheson-Kitagawa
  • model/type: 8014-181S
  • sampling information: 1 or 2 strokes
  • upper measurement limit: 30 ppm
  • detection limit: approximately 0.5 ppm
  • overall uncertainty: unknown
  • method reference: on-site air secondary (manufacturer)
Wipe Sampling Method:
  • Glass Fiber Filter

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