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2-ETHOXYETHANOL (CELLOSOLVE; GLYCOL MONOETHYL ETHER)†

Chemical Identification
CAS #	110-80-5
Formula	C₄H₁₀O₂
Synonyms	Cellosolve; EGEE; ethylene glycol monoethyl ether

Physical Properties
Physical description	Colorless liquid with a sweet, pleasant, ether-like odor.
Boiling point	275°F	Molecular weight	90.14.
Freezing point/melting point	-94°F	Vapor pressure	4 mmHg
Flash point	105°F	Vapor density	3.1
Specific gravity	0.93	Ionization potential
Lower explosive limit (LEL)	1.8%	Upper explosive limit (UEL)	14%
NFPA health rating	1	NFPA fire rating	2
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1033
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA 53 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	200 ppm (740 mg/m³)	REL-TWA	0.5 ppm (18 mg/m³)	TLV-TWA	5 ppm [1981]	PEL-TWA	5 ppm (18 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	Y	Skin notation	Y	Skin notation	Y	Skin notation	Y
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes: BEI®		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	500 ppm
Carcinogenic classifications:		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Ethylene glycol monoethyl ether

NIOSH: Pocket Guide to Chemical Hazards - 2-Ethoxyethanol

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 2-Ethoxyethanol. See annual publication for most recent information.
U.S. EPA Integrated Risk Information System: 2-Ethoxyethanol (CASRN 110-80-5).
MMWR: Criteria for a recommended standard: occupational exposure to ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and their acetates. Morbidity and mortality weekly report 41(21): 386, 1992.
Groeseneken, D., Veulemans, H. and Masschelein, R: Urinary excretion of ethoxyacetic acid after experimental human exposure to ethylene glycol monoethyl ether. Br. J. Ind. Med. 43(9): 615-619, 1986.
Johnson, W., Jr., Cosmetic Ingredient Review Expert Panel: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. Int. J. Toxicol. 21(Suppl. 1): 9-62, 2002.
Kežić, S., Mahieu, K., Monster, A.C. and de Wolff, F.A.: Dermal absorption of vaporous and liquid 2-methoxyethanol and 2-ethoxyethanol in volunteers. Occup. Environ. Med. 54(1): 38-43, 1997.
Pohanish, R.P. (editor): 2-Ethoxyethanol. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1035-1037.
Zissu, D.: Experimental study of cutaneous tolerance to glycol ethers. Contact Dermatitis 32(2): 74-77, 1995.

Last Updated Date : 09/21/2022

N-VALERALDEHYDE

Chemical Identification
CAS #	110-62-3
Formula	C₅H₁₀O
Synonyms	amyl aldehyde; pentanal; valeral; valeraldehyde; valeric aldehyde

Physical Properties
Physical description	Colorless liquid with a strong, acrid, pungent odor.
Boiling point	217°F	Molecular weight	86.14
Freezing point/melting point	-132.7°F	Vapor pressure	26 mmHg
Flash point	53.6°F	Vapor density	3
Specific gravity	0.811	Ionization potential	9.82 eV
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating	2	NFPA fire rating	3
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	V108
Sampling group
Sampler/Sampling media	3 GFFs in 1 cassette; 2 back-to-back, the 3rd separated by a spacer. The filters are coated with 2,4-dinitrophenylhydrazine (DNPH) and phosphoric acid [SKC 225-9020]
Sampling time^*
Sampling volume (TWA)^*	3 L
Sampling flow rate (TWA)^*	0.05 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA 85 (fully validated)
Notes	Sample open-faced!!
Special requirements	Keep samples in darkness after sampling.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA	50 ppm (175 mg/m³)	TLV-TWA	50 ppm [1984]	PEL-TWA	50 ppm (175 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: Not established		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: Not listed		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Valeraldehyde

NIOSH: Pocket Guide to Chemical Hazards - n-Valeraldehyde

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - n-Valeraldehyde. See annual publication for most recent information.
Pohanish, R.P. (editor): Valeraldehyde. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2307-2308.
Wilkin, J.K. and Fortner, G.: Cutaneous vascular sensitivity to lower aliphatic alcohols and aldehydes in Orientals. Alcohol Clin. Exp. Res. 9(6): 522-525, 1985.

Last Updated Date : 01/28/2021

HEXANE (N-HEXANE)†

Chemical Identification
CAS #	110-54-3
Formula	C₆H₁₄
Synonyms	hexyl hydride; normal-hexane

Physical Properties
Physical description	Colorless liquid with a gasoline-like odor.
Boiling point	156°F	Molecular weight	86.2
Freezing point/melting point	-139°F	Vapor pressure	124 mmHg
Flash point	-7°F	Vapor density	2.97
Specific gravity	0.66	Ionization potential	10.18 eV
Lower explosive limit (LEL)	1.1%	Upper explosive limit (UEL)	7.5%
NFPA health rating		NFPA fire rating	3
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1380
Sampling group	OVSG-1
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*	98 min
Sampling volume (TWA)^*	4.9 L
Sampling flow rate (TWA)^*	0.05 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA 5000 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	500 ppm (1800 mg/m³)	REL-TWA	50 ppm (180 mg/m³)	TLV-TWA	50 ppm [1996]	PEL-TWA	50 ppm (176 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	Y	Skin notation	Y
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes: BEI®		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	1100 ppm
Carcinogenic classifications: EPA-II		Notes: 10% of LEL
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Hexane

NIOSH: Pocket Guide to Chemical Hazards - n-Hexane

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Hexane (n-Hexane). See annual publication for most recent information.
ATSDR: Toxicological Profile for n-Hexane. July 1999.
Bolt, H.M., Roos, P.H. and Thier, R.: The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine. Int. Arch. Occup. Environ. Health 76(3): 174-185, 2003.
EPA n-Hexane | IRIS n-hexane 2005
Huang, J; Kato, K; Shibata, E; et al. (1989) Effects of chronic n-hexane exposure on nervous system-specific and muscle-specific proteins. Arch Toxicol 63:381-385.
Issever, H., Malat, G., Sabuncu, H.H. and Yuksel, N.: Impairment of colour vision in patients with n-hexane exposure-dependent toxic polyneuropathy. Occup. Med. 52(4): 183-186, 2002.
IPCS INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY, Health and Safety Guide No. 59, n-hexane, 1991.
Karakaya A., Yücesoy B., Burgaz S., Sabir H.U., Karakaya A.E.: Some immunological parameters in workers occupationally exposed to n-hexane. Hum. Exp. Toxicol. 15(1): 56-8, 1996.
MMWR n-Hexane--Related Peripheral Neuropathy Among Automotive Technicians --- California, 1999—2000, 2001
NIOSH: Criteria for a Recommended Standard - Occupational Exposure to Alkanes (C5-C8). March 1977.

Last Updated Date : 06/23/2022

Group Sampling Information
Sampling Media	Sampling Time (If there are exceptions they will be in Notes)	TWA Sampling Volume (If there are exceptions they will be in Notes)	TWA Flow Rate (If there are exceptions they will be in Notes)
CSC Tube (100/50 mg sections, 20/40 mesh), [SKC 226-01]	240 min	12 L	0.05 L/min

Analytes Sampling Information
Analytes	IMIS Code	Wipe Sampling
Isobutyl Acetate	1534	No
n-Butyl Acetate	0440	No
sec-Butyl Acetate	0441	No
tert-Butyl Acetate	0442	No
Toluene**	2460	No
Ethyl Benzene	1080	No
Perchloroethylene (Tetrachloroethylene)**	2020	No
Trichloroethylene**	2490	No
Xylene	2590	No
Trimethylbenzene	2505	No
Benzene***	0320	No
Ethyl Acetate****	1040	No
n-Propyl Acetate‡	2180	No
Pentane‡‡	1990	No
Cyclohexane‡‡‡	0810	No
Heptane*	1371	No
n-Hexane‡‡‡‡	1380	No
Nonane*	N807	No
Octane*	1957	No

Notes

Request any (up to three (3)) of these analytes together.

Alternatively request IMIS Code Q115 and SLTC will report any significant amounts of these analytes.

Results for unrequested analytes in this group will be reported if significant amount are found.

Toluene, sec-Butyl Acetate, Benzene and Isobutyl Alcohol all have/are known interferences. Please indicate on the 91A which of these compounds are known to be present.

There is no need to contact SLTC before sampling.

*80 min (4L)

**Peak sampling 1 min (0.05 L) and Ceiling sampling 5 min (0.25 L)

***STEL sampling 15 min (0.75 L)

****120 min (6 L)

‡200 min (10 L)

‡‡45 min (2.25 L)

‡‡‡190 min (9.5 L)

‡‡‡‡98 min (4.9 L)

2-METHOXYETHYL ACETATE (METHYL CELLOSOLVE ACETATE; ETHYLENE GLYCOL METHYL ACETATE)†

Chemical Identification
CAS #	110-49-6
Formula	C₅H₁₀O₃
Synonyms	ethylene glycol monomethyl ether acetate; EGMEA; glycol monomethyl ether acetate; Methyl Cellosolve® acetate; 2-methoxyethyl acetate

Physical Properties
Physical description	Colorless liquid with a mild, ether-like odor.
Boiling point	293°F	Molecular weight	118.13
Freezing point/melting point	-85°F	Vapor pressure	5 mmHg
Flash point	120°F	Vapor density	4.07
Specific gravity	1.006	Ionization potential
Lower explosive limit (LEL)	1.7%	Upper explosive limit (UEL)	8.2%
NFPA health rating	2	NFPA fire rating	2
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1170
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA 53 (fully validated)
Notes	Keep samples refrigerated when not in transit. Ship samples overnight with cold-packs as soon as possible.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media	Wipe with charcoal pad, seal in glass vial for shipment. [3M 3500]
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	25 ppm (120 mg/m³)	REL-TWA	0.1 ppm (0.5 mg/m³)	TLV-TWA	0.1 ppm [2005]	PEL-TWA	5 ppm (24 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	Y	Skin notation	Y	Skin notation	Y	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes: BEI®		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	200 ppm
Carcinogenic classifications: Not listed		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Ethylene glycol monomethyl ether acetate

NIOSH: Pocket Guide to Chemical Hazards - Methyl Cellosolve acetate

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 2-Methoxyethyl acetate. See annual publication for most recent information.
Johanson, G.: Toxicity review of ethylene glycol monomethyl ether and its acetate ester. Crit. Rev. Toxicol. 30(3): 307-345, 2000.
Pohanish, R.P. (editor): Methoxyethyl Acetate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1507-1509.

Last Updated Date : 09/22/2022

METHYL (N-AMYL) KETONE†

Chemical Identification
CAS #	110-43-0
Formula	C₇H₁₄O
Synonyms	amyl methyl ketone; n-amyl methyl ketone; 2-heptanone

Physical Properties
Physical description	Colorless to white liquid with a banana-like, fruity odor.
Boiling point	305°F	Molecular weight	114.2
Freezing point/melting point	-32°F	Vapor pressure	3 mmHg
Flash point	102°F	Vapor density
Specific gravity	0.81	Ionization potential	9.33 eV
Lower explosive limit (LEL)	1.1% at 151°F	Upper explosive limit (UEL)	7.9% at 250°F
NFPA health rating	1	NFPA fire rating	2
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1675
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*	480 min
Sampling volume (TWA)^*	1-25 L
Sampling flow rate (TWA)^*	0.01-0.2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	NIOSH 1301 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	100 ppm (465 mg/m³)	REL-TWA	100 ppm (465 mg/m³)	TLV-TWA	50 ppm [1978]	PEL-TWA	50 ppm (235 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	800 ppm
Carcinogenic classifications: Not listed		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Amyl methyl ketone

NIOSH: Pocket Guide to Chemical Hazards - Methyl (n-amyl) ketone

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Methyl n-Amyl Ketone. See annual publication for most recent information.
NIOSH: Criteria for a Recommended Standard: Occupational Exposure to Ketones. June 1978.

Last Updated Date : 01/05/2021

ISOBUTYL ACETATE†

Chemical Identification
CAS #	110-19-0
Formula	C₆H₁₂O₂
Synonyms	isobutyl ester of acetic acid; 2-methylpropyl acetate; 2-methylpropyl ester of acetic acid; β-methylpropyl ethanoate

Physical Properties
Physical description	Colorless liquid with a fruity, floral odor.
Boiling point	243°F	Molecular weight	116.2
Freezing point/melting point	-145°F	Vapor pressure	13 mmHg
Flash point	64°F	Vapor density
Specific gravity	0.87	Ionization potential	9.97 eV
Lower explosive limit (LEL)	1.3%	Upper explosive limit (UEL)	10.5%
NFPA health rating	1	NFPA fire rating	3
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1534	1534
Sampling group	OVSG-1
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]	SKC 575-002 Passive Sampler [SKC 575-002]
Sampling time^*	240 min	240 min TWA; 15 min STEL
Sampling volume (TWA)^*	12 L
Sampling flow rate (TWA)^*	0.05 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID	GC-FID
Method reference	OSHA 5000 (fully validated)	OSHA 1009 (fully validated)
Notes		To obtain sampling and analytical error similar to that available with active sampling, knowledge of the atmospheric pressure and temperature are required, and these should be obtained using NIST-traceable devices. If that is not possible, temperature is assumed to be 22.2 °C, and the atmospheric pressure is estimated based on the elevation of the sampling location. When estimates are used in place of traceable measurements the sampling and analytical error associated with passive sampling is substantially increased, and this makes it more difficult to demonstrate overexposures after considering the 95% lower confidence limit.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	150 ppm (700 mg/m³	REL-TWA	150 ppm (700 mg/m³)	TLV-TWA	50 ppm [2015]	PEL-TWA	150 ppm (700 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL	150 ppm [2015]	PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	1300 ppm
Carcinogenic classifications: Not listed		Notes: 10% of LEL
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Isobutyl acetate

NIOSH: Pocket Guide to Chemical Hazards - Isobutyl acetate

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Isobutyl Acetate. See annual publication for most recent information.
NIOSH: Occupational Health Guideline for Isobutyl Acetate. September 1978.

Last Updated Date : 04/13/2021

Group Sampling Information
Sampling Media	Sampling Time (If there are exceptions they will be in Notes)	TWA Sampling Volume (If there are exceptions they will be in Notes)	TWA Flow Rate (If there are exceptions they will be in Notes)
CSC Tube (100/50 mg sections, 20/40 mesh), [SKC 226-01]	240 min	12 L	0.05 L/min

Analytes Sampling Information
Analytes	IMIS Code	Wipe Sampling
Isobutyl Acetate	1534	No
n-Butyl Acetate	0440	No
sec-Butyl Acetate	0441	No
tert-Butyl Acetate	0442	No
Toluene**	2460	No
Ethyl Benzene	1080	No
Perchloroethylene (Tetrachloroethylene)**	2020	No
Trichloroethylene**	2490	No
Xylene	2590	No
Trimethylbenzene	2505	No
Benzene***	0320	No
Ethyl Acetate****	1040	No
n-Propyl Acetate‡	2180	No
Pentane‡‡	1990	No
Cyclohexane‡‡‡	0810	No
Heptane*	1371	No
n-Hexane‡‡‡‡	1380	No
Nonane*	N807	No
Octane*	1957	No

Notes

Request any (up to three (3)) of these analytes together.

Alternatively request IMIS Code Q115 and SLTC will report any significant amounts of these analytes.

Results for unrequested analytes in this group will be reported if significant amount are found.

Toluene, sec-Butyl Acetate, Benzene and Isobutyl Alcohol all have/are known interferences. Please indicate on the 91A which of these compounds are known to be present.

There is no need to contact SLTC before sampling.

*80 min (4L)

**Peak sampling 1 min (0.05 L) and Ceiling sampling 5 min (0.25 L)

***STEL sampling 15 min (0.75 L)

****120 min (6 L)

‡200 min (10 L)

‡‡45 min (2.25 L)

‡‡‡190 min (9.5 L)

‡‡‡‡98 min (4.9 L)

METHYL ISOAMYL KETONE†

Chemical Identification
CAS #	110-12-3
Formula	C₇H₁₄O
Synonyms	isoamyl methyl ketone; isopentyl methyl ketone; 2-methyl-5-hexanone; 5-methyl-2-hexanone; MIAK; 5-methylhexan-2-one

Physical Properties
Physical description	Colorless, clear liquid with a pleasant, fruity odor.
Boiling point	291°F	Molecular weight	114.2
Freezing point/melting point	-101°F	Vapor pressure	5 mmHg
Flash point	97°F	Vapor density
Specific gravity	0.81	Ionization potential	9.284 eV
Lower explosive limit (LEL)	1% at 200°F	Upper explosive limit (UEL)	8.2% at 200°F
NFPA health rating	1	NFPA fire rating	3
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1776
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*	50 min
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA PV2042 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	100 ppm (475 mg/m³)	REL-TWA	50 ppm (240 mg/m³)	TLV-TWA	20 ppm [2012]	PEL-TWA	50 ppm (234 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL	50 ppm [2012]	PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: Not listed		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - 5-Methylhexan-2-one

NIOSH: Pocket Guide to Chemical Hazards - Methyl isoamyl ketone

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Methyl isoamyl ketone. See annual publication for most recent information.
De Ceaurriz, J., Micillino, J.C., Marignac, B., Bonnet, P., Muller, J. and Guenier, J.P.: Quantitative evaluation of sensory irritating and neurobehavioral properties of aliphatic ketones in mice. Food Chem. Toxicol. 22(7): 545-549, 1984.
Katz, G.V., Renner, E.R., Jr. and Terhaar, C.J.: Subchronic inhalation toxicity of methyl isoamyl ketone in rats. Fundam. Appl. Toxicol. 6(3): 498-505, 1986.
Pohanish, R.P. (editor): Methyl Isoamyl Ketone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1578-1580.

Last Updated Date : 01/05/2021

TETRAHYDROFURAN†

Chemical Identification
CAS #	109-99-9
Formula	C₄H₈O
Synonyms	diethylene oxide; 1,4-epoxybutane; tetramethylene oxide; THF

Physical Properties
Physical description	Colorless liquid with an ether-like odor.
Boiling point	151°F	Molecular weight	72.11
Freezing point/melting point	-163.3°F	Vapor pressure	132 mmHg
Flash point	6°F	Vapor density	2.5
Specific gravity	0.89	Ionization potential	9.45 eV
Lower explosive limit (LEL)	2%	Upper explosive limit (UEL)	11.8%
NFPA health rating	2	NFPA fire rating	3
NFPA reactivity rating	1	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	2390
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	1-9 L
Sampling flow rate (TWA)^*	0.01-0.2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	NIOSH 1609 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device	Detector tube	Detector tube	Detector tube	Detector tube
Model/Type	Gastec 159	Gastec 161	Matheson-Kitagawa 8014-102SA	Matheson-Kitagawa 8014-162U
Sampling information (see manufacturer instructions)	1 or 2 strokes; 2-800 ppm range; uncertainty 25% for 50-200 ppm, 16% for 200-800 ppm	1 stroke; approx 0.03-1.4% range; uncertainty 16%	0.5 or 1 stroke; approx 0.01-5% range	1 stroke; approx 5-400 ppm range

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	200 ppm (590 mg/m³)	REL-TWA	200 ppm (590 mg/m³)	TLV-TWA	50 ppm [2002]	PEL-TWA	200 ppm (590 mg/m³)
PEL-STEL		REL-STEL	250 ppm (735 mg/m³)	TLV-STEL	100 ppm [2002]	PEL-STEL	250 ppm (735 mg/m³)
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	Y	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	2000 ppm
Carcinogenic classifications: TLV-A3		Notes: 10% of LEL
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3: 100 ppm/500 ppm/5000 ppm

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Tetrahydrofuran

NIOSH: Pocket Guide to Chemical Hazards - Tetrahydrofuran

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Tetrahydrofuran. See annual publication for most recent information.
Chhabra R.S., Herbert, R.A., Roycroft, J.H., Chou, B., Miller, R.A. and Renne, R.A.: Carcinogenesis studies of tetrahydrofuran vapors in rats and mice. Toxicol. Sci. 41(2): 183-188, 1998.
Food and Drug Administration: International Conference on Harmonization: final recommendations on the revision of the permitted daily exposures for two solvents, n-methylpyrrolidone and tetrahydrofuran, according to the maintenance procedures for the guidance Q3C Impurities: Residual Solvents; Availability. Notice. Fed. Regist. 68(219): 64352-64353, 2003.
Garnier, R., Rosenberg, N., Puissant, J.M., Chauvet, J.P. and Efthymiou, M.L.: Tetrahydrofuran poisoning after occupational exposure. Br. J. Ind. Med. 46(9): 677-678, 1989.
Pohanish, R.P. (editor): Tetrahydrofuran. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2178-2180.

Last Updated Date : 01/13/2021

ETHYL FORMATE†

Chemical Identification
CAS #	109-94-4
Formula	C₃H₆O₂
Synonyms	ethyl ester of formic acid; ethyl methanoate

Physical Properties
Physical description	Colorless liquid with a fruity odor.
Boiling point	130°F	Molecular weight	74.1
Freezing point/melting point	-113°F	Vapor pressure	200 mmHg
Flash point	-4°F	Vapor density
Specific gravity	0.92	Ionization potential	10.61 eV
Lower explosive limit (LEL)	2.8%	Upper explosive limit (UEL)	16.0%
NFPA health rating	2	NFPA fire rating	3
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1155
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*
Sampling volume (TWA)^*	0.3-10 L
Sampling flow rate (TWA)^*	0.01-0.2 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	NIOSH 1452 (partially validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	100 ppm (300 mg/m³)	REL-TWA	100 ppm (300 mg/m³)	TLV-TWA		PEL-TWA	100 ppm (300 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL	100 ppm [2011]	PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	1500 ppm
Carcinogenic classifications: Not listed		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Ethyl formate

NIOSH: Pocket Guide to Chemical Hazards - Ethyl formate

Literature References

International Chemical Safety Cards (WHO/IPCS/ILO): Ethyl formate.
EPA: Federal Register: Dalapon, Fluchloralin, et al.; Various Tolerance Revocations.
Haritos, V.S. and Dojchinov, G.: Cytochrome c oxidase inhibition in the rice weevil Sitophilus oryzae (L.) by formate, the toxic metabolite of volatile alkyl formates. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 136(2): 135-143, 2003.
Keenes, M., et al.: Disinfestation of food processing equipment. Presented at the 12th Annual International Research Conference on Methyl Bromide Alternatives and Emissions Reduction, San Diego, CA, 30 October - 3 November, 2005.
Pohanish, R.P. (editor): Ethyl Formate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1106-1108.

Last Updated Date : 12/28/2020

DIETHYLAMINE†

Chemical Identification
CAS #	109-89-7
Formula	C₄H₁₁N
Synonyms	diethamine; N,N-diethylamine; N-ethylethanamine

Physical Properties
Physical description	Colorless liquid with a fishy, ammonia-like odor.
Boiling point	132°F	Molecular weight	73.1
Freezing point/melting point	-58°F	Vapor pressure	192 mmHg
Flash point	-15°F	Vapor density	2.53
Specific gravity	0.71	Ionization potential	8.01 eV
Lower explosive limit (LEL)	1.8%	Upper explosive limit (UEL)	10.1%
NFPA health rating	3	NFPA fire rating	3
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0910
Sampling group
Sampler/Sampling media	XAD-7 tube (80/40 mg) coated with 10% NBD chloride [SKC 226-96]
Sampling time^*	50 min
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.2 L/min
Sampling volume (STEL/Peak/C)^*	3 L
Sampling flow rate (STEL/Peak/C)^*	0.2 L/min
Analytical method instruments	HPLC
Method reference	OSHA 41 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device	Detector tube	Detector tube	Infrared spectrophotometer	Infrared spectrophotometer	Photoionization detector (PID)
Model/Type	Gastec 180	Matheson-Kitagawa 8014-222S	Miran 1A & 1B	Miran 103
Sampling information (see manufacturer instructions)	1-60 ppm range	1-20 ppm range	1.1 ppm@9.0 µm	0-50 ppm@8.7 µm

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	25 ppm (75 mg/m³)	REL-TWA	10 ppm (30 mg/m³)	TLV-TWA	5 ppm [2012]	PEL-TWA
PEL-STEL		REL-STEL	25 ppm (75 mg/m³)	TLV-STEL	15 ppm [2012]	PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C	5 ppm (15 mg/m³)
Skin notation	N	Skin notation	N	Skin notation	Y	Skin notation	Y
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	200 ppm
Carcinogenic classifications: TLV-A4		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Diethylamine

NIOSH: Pocket Guide to Chemical Hazards - Diethylamine

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Diethylamine. See annual publication for most recent information.
Occupational Health Guidelines for Chemical Hazards. US Department of Health and Human Services (DHHS), National Institute for Occupational Safety and Health (NIOSH) Publication No. 81-123, (1981, January). Provides a table of contents of guidelines for many hazardous chemicals. The files provide technical chemical information, including chemical and physical properties, health effects, exposure limits, and recommendations for medical monitoring, personal protective equipment (PPE), and control procedures.

Last Updated Date : 12/28/2020

2-ETHOXYETHANOL (CELLOSOLVE; GLYCOL MONOETHYL ETHER)†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

N-VALERALDEHYDE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

HEXANE (N-HEXANE)†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

2-METHOXYETHYL ACETATE (METHYL CELLOSOLVE ACETATE; ETHYLENE GLYCOL METHYL ACETATE)†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

METHYL (N-AMYL) KETONE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

ISOBUTYL ACETATE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

METHYL ISOAMYL KETONE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

TETRAHYDROFURAN†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

ETHYL FORMATE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References

DIETHYLAMINE†

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References