Inhalation of respirable crystalline silica particles has long been known to cause silicosis, a disabling, non-reversible and sometimes fatal lung disease. Respirable crystalline silica also causes lung cancer. The International Agency for Research on Cancer has designated crystalline silica as carcinogenic to humans, and the U.S. National Toxicology Program has concluded that respirable crystalline silica is known to be a human carcinogen. The National Institute for Occupational Safety and Health (NIOSH) has also recommended that respirable crystalline silica be considered a potential occupational carcinogen. In addition, exposure to respirable crystalline silica has been associated with other respiratory diseases, such as chronic obstructive pulmonary disease (including bronchitis and emphysema), as well as kidney and immune system diseases.
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