Occupational Safety and Health Administration OSHA


Toluene - Photo Credit: iStock.com-501196526 | Copyright: Grafner
Toluene Menu

Authoritative Risk Assessment - Information from U.S. Government Agencies

The Environmental Protection Agency (EPA) and the Centers for Disease Control (CDC) Agency for Toxic Substances and Disease Registry (ATSDR) have performed extensive risk assessments more recently than OSHA for many of the chemicals regulated by OSHA in the occupational environment, including toluene.

The EPA Integrated Risk Information System (IRIS) Reference Concentration (RfC) for toluene is 5 mg/m3 (published in 2005).

The CDC Agency for Toxic Substances and Disease Registry (ATSDR) established an Acute Minimal Risk Level (MRL) of 1 ppm and a Chronic MRL of 0.08 ppm in 2000.

  • The acute MRL applies to exposure from 1-14 days, a chronic MRL applies to exposures greater than 1 year. The MRL's would have to be adjusted to a higher value to be applied in an occupational environment.
  • The chronic MRL was derived from a series of studies showing adverse effects on neurological function as shown by impaired color vision in workers exposed to toluene.
  • For additional information on MRL's refer to the Minimal Risk Levels (MRLs) List.
  • The ATSDR Toxicological Profile for toluene is a unique compilation of toxicological information on toluene. The profile reflects a comprehensive and extensive evaluation, summary, and interpretation of available toxicologic and epidemiologic information on toluene.
Back to Top

Thank You for Visiting Our Website

You are exiting the Department of Labor's Web server.

The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Users must request such authorization from the sponsor of the linked Web site. Thank you for visiting our site. Please click the button below to continue.