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Exposure Evaluation

Analytical Methods


For additional information, see OSHA's Sampling and Analysis Safety and Health Topics Page.

National Institute for Occupational Safety and Health (NIOSH)

  • NIOSH Manual of Analytical Methods (NMAM). US Department of Health and Human Services (DHHS), National Institute for Occupational Safety and Health (NIOSH) Publication No. 2003-154, (2003). Provides individual analytical methods, listed by chemical name or method number.


  • U.K. Health and Safety Executive Method 25/2
  • The following are analysis methods for specific isocyanate compounds. It is often desirable to determine the amount of free isocyanate, not just the specific compound. Several methods have been suggested to accomplish this. However, all have had serious problems when applied to field sampling.
    • Streicher, RP, et al. Investigation of the ability of MDHS method 25 to determine urethane-bound isocyanate groups. American Industrial Hygiene Association Journal. 1995;56(5):437-42.
    • Key-Schwartz, RJ. Analytical problems encountered with NIOSH method 5521 for total isocyanates. American Industrial Hygiene Association Journal. 1995;56(5):474-9.
    • Maitre, A., et al. Biological monitoring of occupational exposure to toluene diisocyanate. Int. Arch. Occup. Environ. Health. 1993;65:97-100.
    • Documentation of the threshold limit values and biological exposure indices. American Conference for Government Industrial Hygienists (ACGIH). 1991;6:1581-9.

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