• Part Number:
    1990
  • Part Number Title:
    Identification, Classification, and Regulation of Carcinogens
  • Standard Number:
  • Title:
    Definitions.
  • GPO Source:

Terms used in this part shall have the meanings set forth in the Act. In addition, as used in this part, the following terms shall have the meanings set forth below:

"Act" means the Occupational Safety and Health Act of 1970 (Pub. L. 
91-596, 84 Stat. 1590 et seq., 29 U.S.C. 551 et seq.).  
"Administrator of EPA" means the Administrator of the United States 
Environmental Protection Agency, or designee.  
"Chairperson of CPSC" means the Chairman of the United States Consumer 
Product Safety Commission, or designee.  
"Commissioner of FDA" means the Commissioner of the Food and Drug 
Administration, United States Department of Health and Human Services. or 
designee.  
"Director of NCI" means the Director of the National Cancer Institute. 
United States Department of Health and Human Services, or designee.  
"Director of NIEHS" means the Director of the National Institute of 
Environmental Health Sciences, United States Department of Health and 
Human Services, or designee.  
"Director of NIOSH" means the Director of the National Institute for 
Occupational Safety and Health, United States Department of Health and 
Human Services, or designee.  
"Mutagenesis" means the induction of heritable changes in the 
genetic material of either somatic or germinal cells.  
"Positive results in short-term tests" means positive results in assays 
for two or more of the following types of effect: (1) The induction of DNA 
damage and/or repair; (2) Mutagenesis in bacteria, yeast, Neurospora or 
Drosophila melanogaster (3) Mutagenesis in mammalian somatic cells; (4) 
mutagenesis in mammalian germinal cells; or (5) neoplastic transformation 
of mammalian cells in culture.  
"Potential occupational carcinogen" means any substance, or combination 
or mixture of substances, which causes an increased incidence of benign 
and/ or malignant neoplasms, or a substantial decrease in the latency 
period between exposure and onset of neoplasms in humans or in one or more 
experimental mammalian species as the result of any oral, respiratory or 
dermal exposure, or any other exposure which results in the induction of 
tumors at a site other than the site of administration. This definition 
also includes any substance which is metabolized into one or more 
potential occupational carcinogens by mammals.  
"Secretary of HHS" means the Secretary of the United States Department 
of Health and Human Services, or designee.