1. OSHA Occupational Chemical Database
  2. CHLOROBENZENE
Label abbreviations descriptions

CHLOROBENZENE†

Chemical Identification
Chemical Identification
CAS # 108-90-7
Formula

C₆H₅Cl
Synonyms

benzene chloride; chlorobenzol; MCB; monochlorobenzene; phenyl chloride
Physical Properties
Physical Properties
Physical description Colorless liquid with an almond-like odor.
Boiling point 270°F Molecular weight 112.6
Freezing point/melting point -50°F Vapor pressure 8.8 mmHg
Flash point 75°F Vapor density 3.88
Specific gravity 1.11 Ionization potential 9.07 eV
Lower explosive limit (LEL) 1.3% Upper explosive limit (UEL) 9.6%
NFPA health rating 3 NFPA fire rating 3
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0620
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
Sampling volume (TWA)*

10 L
Sampling flow rate (TWA)*

0.01-0.2 L/min
Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference NIOSH 1003 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

75 ppm (350 mg/m³)

 REL-TWA TLV-TWA

10 ppm [1988]

 PEL-TWA

10 ppm (46 mg/m³)
PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

N

 Skin notation

N

 Skin notation

N

 Skin notation

N
Notes:

See 29 CFR 1910.1000 Table Z-1.

 Notes:

See Appendix D, Substances with No Established RELs

 Notes:

BEI®

 Notes:
Health factors:  See NIH-NLM PubChem. IDLH

1000 ppm
Carcinogenic classifications: EPA-D, TLV-A3 Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Chlorobenzene

NIOSH: Pocket Guide to Chemical Hazards - Chlorobenzene

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Chlorobenzene. See annual publication for most recent information.
  • EPA Air Toxics Website: Chlorobenzene. U.S. Environmental Protection Agency Technology Transfer Network.
  • Arutjunov, V.D., Batsura, Ju.D., Gribova, I.A. and Kruglikov G.G.: Scanning electron-microspic and light-optic investigations of erythrocytes in toxic anaemia. Br. J. Ind. Med. 38(1): 72-75, 1981.
  • Knecht, U. and Woitowitz, H.-J.: Human toxicokinetics of inhaled monochlorobenzene: latest experimental findings regarding re-evaluation of the biological tolerance value. Int. Arch. Occup. Environ. Med. 73(8): 543-554, 2000.
  • National Toxicology Program: NTP Toxicology and Carcinogenesis Studies of Chlorobenzene (CAS No. 108-90-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Natl. Toxicol. Program Tech. Rep. Ser. 261: 1-220, 1985.
  • Nedelcheva, V., Gut, I., Soucek, P. and Frantik, E.: Cytochrome P450 catalyzed oxidation of monochlorobenzene, 1,2- and 1,4-dichlorobenzene in rat, mouse, and human liver microsomes. Chem. Biol. Interact. 115(1): 53-70, 1998.
  • Pohanish, R.P. (editor): Dichlorobenzenes. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 799-804.

Last Updated Date : 12/21/2020