TESTOSTERONE

Chemical Identification
Chemical Identification
CAS # 58-22-0
Formula

C₁₉H₂₈O₂

Synonyms

andro; D4-androsten-17b-ol-3-one; (17b)-17-hydroxyandrost-4-en-3-one; Mertestate; Oreton; testolin; Testro AQ; virosterone

Physical Properties
Physical Properties
Physical description White or slightly cream-white crystals or crystalline powder.
Boiling point Molecular weight 288.43
Freezing point/melting point 311°F Vapor pressure 1.7x10-8 mmHg (est)
Flash point Vapor density
Specific gravity Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) T413
Sampling group
Sampler/Sampling media GFF Gelman Type A (37 mm) in 3-piece cassette no backup pad [SKC 225-706]
Sampling time*

240 min

Sampling volume (TWA)*

240 L

Sampling flow rate (TWA)*

1 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments HPLC
Method reference OSHA PV2001 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA TLV-TWA PEL-TWA
PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

NA

Skin notation

NA

Skin notation

NA

Skin notation

NA

Notes:

Not established

Notes:

Not established

Notes:

Not established

Notes:

Not established

Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

  • National Institute for Occupational Safety and Health: NIOSH Alert: Preventing Occupational Exposure to Antineoplastic and Other Hazardous Drugs in Health Care Settings. NIOSH Publication No. 2004-165.
  • Abitbol, J., Abitbol, P. and Abitbol, B.: Sex hormones and the female voice. J. Voice 13(3): 424-446, 1999.
  • Davison, S., et al.: Pharmacokinetics and acute safety of inhaled testosterone in postmenopausal women. J. Clin. Pharmacol. 45(2): 177-184, 2005.
  • Giammanco, M., Tabacchi, G., Giammanco, S., Di Majo, D. and La Guardia, M.: Testosterone and aggressiveness. Med. Sci. Monit. 11(4): RA136-145, 2005.
  • Rhoden, E.L. and Morgentaler, A.: Risks of testosterone-replacement therapy and recommendations for monitoring. N. Engl. J. Med. 350(5): 482-492, 2004.
  • Rosenfeld, R.L.: Hirsutism and the variable response of the pilosebaceous unit to androgen. J. Investig. Dermatol. Symp. Proc. 10(3): 205-208, 2005.
  • Trenton, A.J. and Currier, G.W.: Behavioral manifestations of anabolic steroid use. CNS Drugs 19(7): 571-595, 2005.
  • Vierhapper, H., Nowotny, P. and Waldhäusl, W.: Determination of testosterone production rates in men and women using stable isotope/dilution and mass spectrometry. J. Clin. Endocrinol. Metab. 82(5): 1492-1496, 1997.
  • Vierhapper, H., Maier, H., Nowotny, P. and Waldhäusl, W.: Production rates of testosterone and of dihydrotestosterone in female pattern hair loss. Metabolism 52(7): 727-729, 2003.
  • World Health Organization: Contraceptive efficacy of testosterone-induced azospermia and oligospermia in normal men. Fertil. Seril. 65(4): 821-829, 1996.
  • Zouboulis, C.C., Chen, W.C., Thornton, M.J. Qin, K. and Rosenfield, R.: Sexual hormones in human skin. Horm. Metab. Res. 39(2): 85-95, 2007.
  • Zumoff, B., Strain, G.W., Miller, L.K. and Rosner, W.: Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. J. Clin. Endocrinol. Metab. 80(4): 1429-1430, 1995.

Last Updated Date : 01/12/2021