N-NITROSODIETHYLAMINE

Chemical Identification
Chemical Identification
CAS # 55-18-5
Formula

C₄H₁₀N₂O

Synonyms

NDEA; DENA; DEN; DANA; diethylnitrosamine; diethylnitroso-amine; N,N-diethylnitrosamine; ethylamine, N-nitrosdi; N-ethyl-N-nitroso-ethanamine; nitrosodiethylamine

Physical Properties
Physical Properties
Physical description Clear slightly yellow liquid.
Boiling point 351°F Molecular weight 102.14
Freezing point/melting point Vapor pressure 5.7 mmHg
Flash point 145°F Vapor density
Specific gravity 0.9422 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1947
Sampling group
Sampler/Sampling media ThermoSorb/N air sampler [No longer available]
Sampling time*
Sampling volume (TWA)*

75 L

Sampling flow rate (TWA)*
 

0.2-2 L/min

Sampling volume (STEL/Peak/C)*
 

 

Sampling flow rate (STEL/Peak/C)*
 

 

Analytical method instruments GC-TEA
Method reference OSHA 27 (fully validated)
Notes
 

This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-4900.

Special requirements
 

Store samples in freezer.

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

 

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

 

REL-TWA
 

 

TLV-TWA
 

 

PEL-TWA
 

 

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

 

PEL-STEL
 

 

PEL-C
 

 

REL-C
 

 

TLV-C
 

 

PEL-C
 

 

Skin notation
 

NA

Skin notation
 

NA

Skin notation
 

NA

Skin notation
 

NA

Notes:
 

Not established

Notes:
 

Not established

Notes:
 

Not established

Notes:
 

Not established

Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: NTP, IARC-2A, EPA-B2 Notes:
 

 

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosodiethylamine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosodiethylamine

Literature References

 
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: IA3500000.
  • California Department of Public Health (CDPH): NDMA and Other Nitrosamines - Drinking Water Issues.
  • U.S. EPA Integrated Risk Information System: N-Nitrosodiethylamine (CASRN 55-18-5).
  • Godoy, W., et al.: CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism. Carcinogenesis 23(4): 611-616, 2002.
  • Ito, N., Tamano, S. and Shirai, T.: A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci. 94(1): 3-8, 2003.
  • Moennikes, O., et al.: A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice. Cancer Res. 64(14): 4707-4710, 2004.
  • No Author: N-Nitrosodiethylamine (CAS No. 55-18-5) . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • Oury, B., Limasset, J.C. and Protois, J.C.: Assessment of exposure to carcinogenic N-nitrosamines in the rubber industry. Int. Arch. Occup. Environ. Health 70(4): 261-271, 1997.
  • Pohanish, R.P. (editor): N-Nitrosodiethylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1730-1731.
  • Sansone, E.B. and Keimig, S.D.: Potential occupational exposure associated with parenteral administration of N-nitrosodiethylamine to Macaca mulatta: evidence of post-injection release to the atmosphere. IARC Sci. Publ. 105: 226-229, 1991.
  • Su, T., Bao, Z., Zhang, Q.-Y., Smith, T.J., Hong, J.-Y. and Ding, X.: Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 60(18): 5074-5079, 2000.
  • Verna, L., Whysner, J. and Williams, G.M.: N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol. Ther. 71(1-2): 57-81, 1996.

Last Updated Date : 01/05/2021