ISOFLURANE

Chemical Identification
Chemical Identification
CAS # 26675-46-7
Formula

C₃H₂ClF₅O

Synonyms

1-chloro-2,2,2-trifluoroethyl difluoromethyl ether; 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro ethane; forane

Physical Properties
Physical Properties
Physical description Colorless liquid
Boiling point 119.3°F Molecular weight 184.5
Freezing point/melting point Vapor pressure 330 mmHg
Flash point Vapor density
Specific gravity 1.45 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) F118
Sampling group
Sampler/Sampling media Anasorb 747 (140/70 mg) [SKC 226-81A]
Sampling time*

240 min

Sampling volume (TWA)*

12 L

Sampling flow rate (TWA)*

0.05 L/min

Sampling volume (STEL/Peak/C)*

0.75 L

Sampling flow rate (STEL/Peak/C)*

0.05 L/min

Analytical method instruments GC-FID
Method reference OSHA 103 (fully validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA TLV-TWA PEL-TWA

2 ppm (15 mg/m³)

PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

NA

Skin notation

NA

Skin notation

NA

Skin notation

N

Notes:

Not established. See OSHA publication Anesthetic Gases: Guidelines for Workplace Exposures (2000).

Notes:

Not established

Notes:

Not established

Notes:
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: IARC-3 Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not Listed

NIOSH: Pocket Guide to Chemical Hazards - Not Listed

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Chemical Substances and Other Issues Under Study: Isoflurane. See annual publication for most recent information.
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KN6799000
  • .
  • Accorsi, A., Barbieri, A., Raffi, G.B. and Violante, F.S.: Biomonitoring of exposure to nitrous oxide, sevoflurane, isoflurane and halothane by automated GC/MS headspace urinalysis. Int. Arch. Occup. Environ. Health 74(8): 541-548, 2001.
  • Beckman, N.J., Zacny, J.P. and Walker, D.J.: Within-subject comparison of the subjective and psychomotor effects of a gaseous anesthetic and two volatile anesthetics in health volunteers. Drug Alcohol Depend. 81(1): 89-95, 2006.
  • Kharasch, E.D., Hankins, D.C. and Cox, K.: Clinical isoflurane metabolism by cytochrome P450 2E1. Anesthesiology 90(3): 766-771, 1999.
  • Kuhlman, J.J., Jr., Magluilo, J., Jr., Levine, B. and Smith, M.L.: Two deaths involving isoflurane abuse. J. Forensic Sci. 38(4): 968-971, 1993.
  • Stachnik, J.: Inhaled anesthetic agents. Am. J. Health Syst. Pharm. 63(7): 623-634, 2006.
  • TerRiet, M.F., et al.: Which is most pungent: isoflurane, sevoflurane or desflurane? Br. J. Anaesth. 85(2): 305-307, 2000.

Last Updated Date : 12/31/2020