CARBON TETRACHLORIDE (TETRACHLOROMETHANE)

Chemical Identification
Chemical Identification
CAS # 56-23-5
Formula

CCl₄

Synonyms

carbon chloride; carbon tet; Freon® 10; Halon® 104; tetrachloromethane

Physical Properties
Physical Properties
Physical description Clear liquid with a characteristic odor.
Boiling point 170.1°F Molecular weight 153.82
Freezing point/melting point -9°F Vapor pressure 91 mmHg
Flash point Vapor density 5.3
Specific gravity 1.59 Ionization potential 11.47 eV
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating 3 NFPA fire rating 0
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0570
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
Sampling volume (TWA)*

15 L

Sampling flow rate (TWA)*

0.01-0.2 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference NIOSH 1003 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

10 ppm

REL-TWA TLV-TWA

5 ppm [1990]

PEL-TWA

2 ppm (12.6 mg/m³)

PEL-STEL REL-STEL

2 ppm (12.6 mg/m³) [60 minutes]

TLV-STEL

10 ppm [1990]

PEL-STEL

10 ppm (63 mg/m³)

PEL-C

25 ppm [5 min in any 4 hrs]; 200 ppm (Peak)

REL-C TLV-C PEL-C

200 ppm

Skin notation

Y

Skin notation

N

Skin notation

Y

Skin notation

Y

Notes:

See 29 CFR 1910.1000 Table Z-2. OSHA Construction and Maritime Industry PEL is 10 ppm (65 mg/m³) for an 8-hr TWA and the skin designation applies to these sections only. See 29 CFR 1926.55 Appendix A and 29 CFR 1915.1000 Table Z-Shipyards.

Notes:

CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION. See Appendix A, NIOSH Potential Occupational Carcinogens.

Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH

200 ppm

Carcinogenic classifications: TLV-A2, IARC-2B, EPA-B2 Notes:

Ca

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Carbon tetrachloride

NIOSH: Pocket Guide to Chemical Hazards - Carbon tetrachloride

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Carbon tetrachloride. See annual publication for most recent information.
  • EPA Air Toxics Website: Carbon tetrachloride. U.S. Environmental Protection Agency Technology Transfer Network.
  • No Author: Carbon tetrachloride. IARC Monogr. Eval. Carcinog. Risks Hum. 71 (pt. 2): 401-432, 1999.
  • No Author: Carbon Tetrachloride. Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • Manno, M. and Rezzadore, M. Critical role of ethanol abuse in carbon tetrachloride poisoning. Lancet 343(891): 232, 1994.
  • Pohanish, R.P. (editor). Carbon Tetrachloride. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 501-504.
  • Takahashi, S., et al. Increased cytotoxicity of carbon tetrachloride in a human hepatoma cell line overexpressing cytochrome P450 2E1. J. Int. Med. Res. 30(4): 400-405, 2002.
  • Zangar, R.C., Benson, J.M., Burnett, V.L. and Springer, D.L.: Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes. Chem. Biol. Interact. 125(3): 233-243, 2000.

Last Updated Date : 12/21/2020