1. OSHA Occupational Chemical Database
  2. 4-AMINOPYRIDINE
Label abbreviations descriptions

4-AMINOPYRIDINE

Chemical Identification
Chemical Identification
CAS # 504-24-5
Formula

C₅H₆N₂
Synonyms

4-pyridinamine; avitrol
Physical Properties
Physical Properties
Physical description White crystalline material with no odor.
Boiling point 524.3°F Molecular weight 94.13
Freezing point/melting point 604.4°F Vapor pressure
Flash point Vapor density
Specific gravity 1.2607 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) A173
Sampling group
Sampler/Sampling media 2 GFFs (37 mm) coated with sulfuric acid, in 3-piece cassette, separated by the ring section [SKC 225-9004]
Sampling time*
Sampling volume (TWA)*

240 L
Sampling flow rate (TWA)*

1 L/min
Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-NPD
Method reference OSHA PV2143 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA
 

 

 TLV-TWA
 

 

 PEL-TWA
 

 
PEL-STEL REL-STEL
 

 

 TLV-STEL
 

 

 PEL-STEL
 

 
PEL-C
 

 

 REL-C
 

 

 TLV-C
 

 

 PEL-C
 

 
Skin notation
 

NA

 Skin notation
 

NA

 Skin notation
 

NA

 Skin notation
 

NA
Notes:
 

Not established

 Notes:
 

Not established

 Notes:
 

Not established

 Notes:
 

Not established
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: Notes:
 

 
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Pyridine, 4-amino

NIOSH: Pocket Guide to Chemical Hazards - Pyridine, 4-amino

Literature References

 
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: US1750000
  • Hayes, K.C.: The use of 4-aminopyridine (fampridine) in demyelinating disorders. CNS Drug Rev. 10(4): 295-316, 2004.
  • Pohanish, R.P. (editor): 4-Aminopyridine. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 141-143.
  • Velez, L., Shirazi, F., Goto, C., Shepherd, G. and Roth, B.A.: Opisthotonic posturing with neuromuscular irritability attributable to 4-aminopyridine ingestion by a healthy pediatric patient. Pediatrics 111(1): e82-84, 2003.

Last Updated Date : 12/15/2020