1. OSHA Occupational Chemical Database
  2. 3-AMINOPYRIDINE
Label abbreviations descriptions

3-AMINOPYRIDINE

Chemical Identification
Chemical Identification
CAS # 462-08-08
Formula

C₅H₆N₂
Synonyms

ß-aminopyridine; 3-AP; 3-pyridylamine m-aminopyridine; amino-3-pyridine; ß-pyridylamine
Physical Properties
Physical Properties
Physical description White to yellow-brown crystals with an unpleasant odor.
Boiling point 483.8°F Molecular weight 94.13
Freezing point/melting point 147.2°F Vapor pressure
Flash point 190.4°F Vapor density
Specific gravity Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) A174
Sampling group
Sampler/Sampling media 2 GFFs (37 mm) coated with sulfuric acid, in 3-piece cassette, separated by the ring section [SKC 225-9004]
Sampling time*

240 min
Sampling volume (TWA)*

240 L
Sampling flow rate (TWA)*

1 L/min
Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-NPD
Method reference OSHA PV2143 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 
Bulk Method
Bulk Method
 

 
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

 

 REL-TWA
 

 

 TLV-TWA
 

 

 PEL-TWA
 

 
PEL-STEL
 

 

 REL-STEL
 

 

 TLV-STEL
 

 

 PEL-STEL
 

 
PEL-C
 

 

 REL-C
 

 

 TLV-C
 

 

 PEL-C
 

 
Skin notation
 

NA

 Skin notation
 

NA

 Skin notation
 

NA

 Skin notation
 

NA
Notes:
 

Not established

 Notes:
 

Not established

 Notes:
 

Not established

 Notes:
 

Not established
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: Notes:
 

 
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Aminopyridines

NIOSH: Pocket Guide to Chemical Hazards - Aminopyridines

Literature References

 
  • Acros Organics N.V.: Material Safety Data Sheet: 3-Aminopyridine, 99%.
  • Galvan, M., Franz, P. and Vogel-Weins, C.: Actions of potassium channel blockers on guinea-pig lateral olfactory tract axons. Naunyn-Schmiedebergs Arch. Pharmacol. 325(1): 8-11, 1984.
  • Riker, W.K., Matsumoto, M. and Takashima, K.: Synaptic facilitation by 3-aminopyridine and its antagonism by verapamil and diltiazem. J. Pharmacol. Exp. Ther. 235(2): 431-435, 1985.
  • Slezia, A., et al.: Uridine release during aminopyridine-induced epilepsy. Neurobiol. Dis. 16(3): 490-499, 2004.

Last Updated Date : 12/15/2020