1-BROMOPROPANE

Lapse in Appropriations

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Chemical Identification
CAS #	106-94-5
Formula	C₃H₇Br
Synonyms	nPB, propyl bromide, n-propyl bromide

Physical Properties
Physical description	A flammable or combustible colorless liquid.
Boiling point	159.6°F	Molecular weight	123.01
Freezing point/melting point	-166°F	Vapor pressure	274.01 mmHg
Flash point	71.6°F (closed cup)	Vapor density
Specific gravity	1.3537	Ionization potential
Lower explosive limit (LEL)	4.6%	Upper explosive limit (UEL)
NFPA health rating	2	NFPA fire rating	2
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	R290
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*	240 min
Sampling volume (TWA)^*	12 L
Sampling flow rate (TWA)^*	0.05 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA 1017 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA	0.1 ppm [2013]	PEL-TWA	5 ppm (25 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	N	Skin notation	Y
Notes: Not established		Notes: Not established		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: TLV-A3		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - 1-Bromopropane

NIOSH: Pocket Guide to Chemical Hazards - 1-Bromopropane

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 1-Bromopropane. See annual publication for most recent information.
International Chemical Safety Cards (WHO/IPCS/ILO): 1-Bromopropane.
U.S. Environmental Protection Agency: EPA's 2007 Final and Proposed Regulations for n-Propyl Bromide (nPB).
U.S. Environmental Protection Agency: EPA Newsroom (1) Compound Allowed as Alternative to Ozone-Depleting Chemicals for Specific Uses (press release on 05/17/2007).
B'Hymer, C. and Cheever, K.L.: Development of a gas chromatographic test for the quantification of the biomarker 3-bromopropionic acid in human urine. J. Chromatogr. B Analyt. Technol. Biomed. LifeSci. 802(2): 361-366, 2004.
Furuhashi, K., et al.: Effects of exposure of rat dams to 1-bromopropane during pregnancy and lactation on growth and sexual maturation of their offspring. Toxicology 224(3): 219-228, 2006.
Hanley, K.W., Petersen, M., Curwin, B.D. and Sanderson, W.T.: Urinary bromide and breathing zone concentrations of 1-bromopropane from workers exposed to flexible foam spray adhesives. Ann. Occup. Hyg. 50(6): 599-607, 2006.
Harney, J.M., Hess, J., Reh, C. and Trout, D.: NIOSH health hazard evaluation report 2000-0410-2891, STN Cushion Company, Thomasville, North Carolina (August) 2002, 39 pp.
Harney, J.M., Nemhauser, J.B., Reh, C.M., Trout, D. and Schrader, S.: NIOSH health hazard evaluation report HETA 99-0260-2906, Marx Industries, Inc., Sawmills, North Carolina (June) 2003, 54 pp.
Ichihara, G.: Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane. Int. Arch. Occup. Environ. Med. 78(2): 79-96, 2005.
Ichihara, G., et al.: A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane. Am. J. Ind. Med. 45(1): 63-75, 2004.
Ichihara, G., et al.: Neurologic abnormalities in workers of a 1-bromopropane factory. Environ. Health Perspect. 112(13): 1319-1325, 2004.
Majersik, J.J., Caravati, E.M. and Steffens, J.D.: Severe neurotoxicity associated with exposure to the solvent 1-bromopropane (n-propyl bromide). Clin. Toxicol. (Phila.) 45(3): 270-276, 2007.
National Toxicology Program: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 1-Bromopropane (1-BP). NTP CERHR MON. (9): i-III11, 2003.
Pohanish, R.P. (editor): Bromopropane. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 380-381.
Toraason, M., et al.: DNA damage in leukocytes of workers occupationally exposed to 1-bromopropane. Mutat. Res. 603(1): 1-14, 2006.

Last Updated Date : 12/15/2020

Lapse in Appropriations

1-BROMOPROPANE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References