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1-BROMOPROPANE

Chemical Identification
Chemical Identification
CAS # 106-94-5
Formula

C₃H₇Br

Synonyms

nPB, propyl bromide, n-propyl bromide

Physical Properties
Physical Properties
Physical description A flammable or combustible colorless liquid.
Boiling point 159.6°F Molecular weight 123.01
Freezing point/melting point -166°F Vapor pressure 274.01 mmHg
Flash point 71.6°F (closed cup) Vapor density
Specific gravity 1.3537 Ionization potential
Lower explosive limit (LEL) 4.6% Upper explosive limit (UEL)
NFPA health rating 2 NFPA fire rating 2
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) R290
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*

240 min

Sampling volume (TWA)*

12 L

Sampling flow rate (TWA)*

0.05 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference OSHA 1017 (fully validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA TLV-TWA

0.1 ppm [2013]

PEL-TWA

5 ppm (25 mg/m³)

PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

NA

Skin notation

NA

Skin notation

N

Skin notation

Y

Notes:

Not established

Notes:

Not established

Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: TLV-A3 Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - 1-Bromopropane

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 1-Bromopropane. See annual publication for most recent information.
  • International Chemical Safety Cards (WHO/IPCS/ILO): 1-Bromopropane.
  • U.S. Environmental Protection Agency: EPA's 2007 Final and Proposed Regulations for n-Propyl Bromide (nPB).
  • U.S. Environmental Protection Agency: EPA Newsroom (1) Compound Allowed as Alternative to Ozone-Depleting Chemicals for Specific Uses (press release on 05/17/2007).
  • B'Hymer, C. and Cheever, K.L.: Development of a gas chromatographic test for the quantification of the biomarker 3-bromopropionic acid in human urine. J. Chromatogr. B Analyt. Technol. Biomed. LifeSci. 802(2): 361-366, 2004.
  • Furuhashi, K., et al.: Effects of exposure of rat dams to 1-bromopropane during pregnancy and lactation on growth and sexual maturation of their offspring. Toxicology 224(3): 219-228, 2006.
  • Hanley, K.W., Petersen, M., Curwin, B.D. and Sanderson, W.T.: Urinary bromide and breathing zone concentrations of 1-bromopropane from workers exposed to flexible foam spray adhesives. Ann. Occup. Hyg. 50(6): 599-607, 2006.
  • Harney, J.M., Hess, J., Reh, C. and Trout, D.: NIOSH health hazard evaluation report 2000-0410-2891, STN Cushion Company, Thomasville, North Carolina (August) 2002, 39 pp.
  • Harney, J.M., Nemhauser, J.B., Reh, C.M., Trout, D. and Schrader, S.: NIOSH health hazard evaluation report HETA 99-0260-2906, Marx Industries, Inc., Sawmills, North Carolina (June) 2003, 54 pp.
  • Ichihara, G.: Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane. Int. Arch. Occup. Environ. Med. 78(2): 79-96, 2005.
  • Ichihara, G., et al.: A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane. Am. J. Ind. Med. 45(1): 63-75, 2004.
  • Ichihara, G., et al.: Neurologic abnormalities in workers of a 1-bromopropane factory. Environ. Health Perspect. 112(13): 1319-1325, 2004.
  • Majersik, J.J., Caravati, E.M. and Steffens, J.D.: Severe neurotoxicity associated with exposure to the solvent 1-bromopropane (n-propyl bromide). Clin. Toxicol. (Phila.) 45(3): 270-276, 2007.
  • National Toxicology Program: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 1-Bromopropane (1-BP). NTP CERHR MON. (9): i-III11, 2003.
  • Pohanish, R.P. (editor): Bromopropane. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 380-381.
  • Toraason, M., et al.: DNA damage in leukocytes of workers occupationally exposed to 1-bromopropane. Mutat. Res. 603(1): 1-14, 2006.

Last Updated Date : 12/15/2020