1. OSHA Occupational Chemical Database
  2. ACETIC ANHYDRIDE
Label abbreviations descriptions

ACETIC ANHYDRIDE†

Chemical Identification
Chemical Identification
CAS # 108-24-7
Formula

C₄H₆O₃
Synonyms

acetic acid anhydride; acetic oxide; acetyl oxide; ethanoic anhydride
Physical Properties
Physical Properties
Physical description Colorless liquid with a strong, pungent, vinegar-like odor.
Boiling point 282°F Molecular weight 102.1
Freezing point/melting point -99°F Vapor pressure 4 mmHg
Flash point 120°F Vapor density 3.52
Specific gravity 1.08 Ionization potential 10.00 eV
Lower explosive limit (LEL) 2.7% Upper explosive limit (UEL) 10.3%
NFPA health rating 3 NFPA fire rating 2
NFPA reactivity rating 1 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0030
Sampling group
Sampler/Sampling media GFFs coated with veratrylamine (3,4-dimethoxybenzylamine) and di-n-octyl phthalate [SLTC100]
Sampling time*
Sampling volume (TWA)*

7.5 L
Sampling flow rate (TWA)*

0.05 L/min
Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-NPD
Method reference OSHA 102 (fully validated)
Notes

These media are prepared by SLTC as needed and are not available for immediate shipment. Please allow time for SLTC to prepare these media prior to sampling.

 
Special requirements

Store filters under refrigeration and use within 1 month. Small interfering peaks start appearing after that time.

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device Detector tube
Model/Type Gastec 81
Sampling information
(see manufacturer instructions) 		1 stroke, approx 0.3-15 ppm range, 16.4% uncertainty
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

5 ppm (20 mg/m³)

 REL-TWA TLV-TWA

1 ppm [2010]

 PEL-TWA
PEL-STEL REL-STEL TLV-STEL

3 ppm [2010]

 PEL-STEL
PEL-C REL-C

5 ppm (20 mg/m³)

 TLV-C PEL-C

5 ppm (20 mg/m³)
Skin notation

N

 Skin notation

N

 Skin notation

N

 Skin notation

N
Notes:

See 29 CFR 1910.1000 Table Z-1.

 Notes: Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH

200 ppm
Carcinogenic classifications: TLV-A4 Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

0.5 ppm/15 ppm/100 ppm
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Acetic anhydride

NIOSH: Pocket Guide to Chemical Hazards - Acetic anhydride

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Acetic anhydride. See annual publication for most recent information.
  • Wagner, F.S., Jr.: Acetic anhydride. In: Kirk-Othmer Encyclopedia of Chemical Technology, 4th Ed., Vol. 1. New York: John Wiley and Sons, pp.142-154, 1991.
  • Sinclair, J.S., McManus, D.T., O'Hara, M.D. and Millar, R.: Fatal inhalation injury following an industrial accident involving acetic anhydride. Burns 20(5): 469-470, 1994.

Last Updated Date : 12/15/2020