O-DICHLOROBENZENE†

Chemical Identification
Chemical Identification
CAS # 95-50-1
Formula

C₆H₄Cl₂

Synonyms

o-DCB; 1,2-dichlorobenzene; ortho-dichlorobenzene; o-dichlorobenzol

Physical Properties
Physical Properties
Physical description Colorless to pale-yellow liquid with a pleasant, aromatic odor.
Boiling point 357°F Molecular weight 147
Freezing point/melting point 1°F Vapor pressure 1 mmHg@68°F, 1.5 mmHg@77°F
Flash point 151°F Vapor density 5.05
Specific gravity 1.306 Ionization potential 9.06 eV
Lower explosive limit (LEL) 2.2% Upper explosive limit (UEL) 9.2%
NFPA health rating 2 NFPA fire rating 2
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0867
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
Sampling volume (TWA)*

1-10 L

Sampling flow rate (TWA)*

0.01-0.2 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference NIOSH 1003 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

 

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

 

REL-TWA
 

 

TLV-TWA
 

25 ppm [1990]

PEL-TWA
 

25 ppm (150 mg/m³)

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

50 ppm [1990]

PEL-STEL
 

 

PEL-C
 

50 ppm (300 mg/m³)

REL-C
 

50 ppm (300 mg/m³)

TLV-C
 

 

PEL-C
 

50 ppm

Skin notation
 

N

Skin notation
 

N

Skin notation
 

N

Skin notation
 

Y

Notes:
 

See 29 CFR 1910.1000 Table Z-1.

Notes:
 

 

Notes:
 

 

Notes:
 

 

Health factors:  See NIH-NLM PubChem. IDLH
 

200 ppm

Carcinogenic classifications: IARC-3, TLV-A4, EPA-D Notes:
 

 

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - O-Dichlorobenzene

NIOSH: Pocket Guide to Chemical Hazards - o-Dichlorobenzene

Literature References

 
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - o-Dichlorobenzene. See annual publication for most recent information.
  • U.S. EPA Integrated Risk Information System: 1,2-Dichlorobenzene (CASRN 95-50-1).
  • Hissink, A.M., Van Ommen, B., Krüse, J. and Van Bladeren, P.J.: A physiologically based pharmacokinetic (PB-PK) model for 1,2-dichlorobenzene linked to two possible parameters of toxicity. Toxicol. Appl. Pharmacol. 145(2): 301-310, 1997.
  • Kumagai, S. and Matsunaga, I.: Relations between exposure to o-dichlorobenzene and concentrations of urinary metabolites. J. Occup. Health 39(2): 124-129, 1997.
  • McDougal, J.N., Grabau, J.H., Dong, I., Mattie, D.R. and Jepson, G.W.: Inflammatory damage to skin by prolonged contact with 1,2-dichlorobenzene and chloropentafluorobenzene. Microsc. Res. Tech. 37(3): 214-220, 1997.
  • Pohanish, R.P. (editor): Dichlorobenzenes. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 799-804.
  • Violante, F.S., Milani, S., Malenchini, G. and Barbieri, A.: Chloracne due to o-dichlorobenzene in a laboratory worker. Contact Dermatitis 52(2): 108, 2005.
  • Zapata-Gayon, C., Zapata-Gayon, N. and Gonzalez-Angulo, A.: Clastogenic chromosomal aberrations in 26 individuals accidentally exposed to ortho dichlorobenzene vapors in the National Medical Center in Mexico City. Arch. Environ. Health 37(4): 231-235, 1982.
  • Zenser, L.-P., Lang, A. and Knecht, U.: N-Acetyl-S-(dichlorophenyl)cysteines as suitable biomarkers for the monitoring of occupational exposure to 1,2-dichlorobenzene. Int. Arch. Occup. Environ. Health 69(4): 252-254, 1997.

Last Updated Date : 01/07/2021