2,6-TOLUENE-DIISOCYANATE (TDI) | Occupational Safety and Health Administration

2,6-TOLUENE-DIISOCYANATE (TDI)

Chemical Identification
Chemical Identification
CAS #	91-08-7
Formula	C₉H₆N₂O₂
Synonyms	2,6-toluene diisocyanate; 2,6-TDI; 2,6-diisocyanato-1-methylbenzene; 2,6-diisocyanatotoluene

Physical Properties
Physical Properties
Physical description	Colorless to pale-yellow solid or liquid with a pungent odor.
Boiling point	264-271°F	Molecular weight	174.2
Freezing point/melting point	68-72°F	Vapor pressure	0.5 mmHg at 77°F for 80% 2,4:20%; 2,6 TDI mixture
Flash point		Vapor density	6
Specific gravity	1.2244 at 68°F	Ionization potential
Lower explosive limit (LEL)	0.9%	Upper explosive limit (UEL)	9.5%
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	T177
Sampling group
Sampler/Sampling media	Isocyanate Sampling Filter Kit - GFF (37 mm, open-faced) coated with 1 mg 1-(2-pyridyl)piperazine [SLTC103]
Sampling time^*	15 min
Sampling volume (TWA)^*	15 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	HPLC
Method reference	OSHA 5002 (fully validated)
Notes	Refrigerate coated filters until used. Sample open-faced!!
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media

Bulk Method
Bulk Method

On-Site Screening Techniques
On-Site Screening Techniques
Device	Detector tube
Model/Type	Dräger - Toluene diisocyanate 0.02/a, 6724501
Sampling information (see manufacturer instructions)	25 strokes, approx 0.02-0.2 ppm range, uncertainty 30%

Exposure Limits
Exposure Limits
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA	0.001 ppm (inhalable fraction and vapor) [2015]	PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL	0.005 ppm (inhalable fraction and vapor) [2015]	PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	Y	Skin notation	NA
Notes: See 2,4-TOLUENE-DIISOCYANATE		Notes: Not established		Notes: dermal sensitizer (DSEN), respiratory sensitizer (RSEN)		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-2B, NIOSH-Ca, NTP-R		Notes:

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3: 0.01 ppm/0.15 ppm/0.6 ppm

Additional Resources and Literature References
Additional Resources and Literature References
NOAA: CAMEO Chemicals - Toluene-2,6-diisocyanate NIOSH: Pocket Guide to Chemical Hazards - Not listed Literature References ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Toluene diisocyanate, 2,4 or 2,6- (or as a mixture). See annual publication for most recent information. NIOSH: Alert -Preventing asthma and death from diisocyanate exposure. DHHS (NIOSH) Publication No. 96-111. 1996. NIOSH: Current Intelligence Bulletin 53 - Toluene Diisocyanate (TDI) and Toluenediamine (TDA) -Evidence of Carcinogenicity. December 1989. NIOSH/CEC/ICPS: International Chemical Safety Cards - Toluene-2,6-diisocyanate. November 1998.

Last Updated Date : 04/19/2021