1. OSHA Occupational Chemical Database
  2. WARFARIN
Label abbreviations descriptions

WARFARIN†

Chemical Identification
Chemical Identification
CAS # 81-81-2
Formula

C₁₉H₁₆O₄
Synonyms

3-(α-Acetonyl)-benzyl-4-hydroxycoumarin; 4-hydroxy-3-(3-oxo-1-phenyl butyl)-2H-1-benzopyran-2-one; WARF
Physical Properties
Physical Properties
Physical description Colorless, odorless, crystalline powder or solid.
Boiling point decomposes Molecular weight 308.32
Freezing point/melting point 322°F Vapor pressure 0.09 mmHg at 71°F
Flash point Vapor density
Specific gravity Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 2586
Sampling group
Sampler/Sampling media PTFE filter, 1 µm [SKC 225-2705]
Sampling time*
Sampling volume (TWA)*

200-1000 L
Sampling flow rate (TWA)*

1-4 L/min
Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments HPLC-UV
Method reference NIOSH 5002 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

0.1 mg/m³

 REL-TWA

0.1 mg/m³

 TLV-TWA

0.01 mg/m³ (inhalable particulate matter) [2015]

 PEL-TWA

0.1 mg/m³
PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

N

 Skin notation

N

 Skin notation

Y

 Skin notation

N
Notes:

See 29 CFR 1910.1000 Table Z-1.

 Notes: Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH

100 mg/m³
Carcinogenic classifications: Not listed Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Warfarin

NIOSH: Pocket Guide to Chemical Hazards - Warfarin

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Warfarin. See annual publication for most recent information.
  • Pohanish, R.P. (editor): Warfarin. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2337-2339.
  • Wittkowsky, A.K.: Warfarin and other coumarin derivatives: pharmacokinetics, pharmacodynamics, and drug interactions. Semin. Vasc. Med. 3(3): 221-230, 2003.

Last Updated Date : 01/14/2021