ISOPHORONE†

Chemical Identification
Chemical Identification
CAS # 78-59-1
Formula

C₉H₁₄O

Synonyms

isoacetophorone; 3,5,5-trimethyl-2-cyclohexenone; 3,5,5-trimethyl-2-cyclo-hexen-1-one

Physical Properties
Physical Properties
Physical description Colorless to white liquid with a camphor-like odor.
Boiling point 419.4°F Molecular weight 138.21
Freezing point/melting point 17°F Vapor pressure 0.3 mmHg
Flash point 184°F Vapor density 4.77
Specific gravity 0.92 Ionization potential 9.07 eV
Lower explosive limit (LEL) 0.8% Upper explosive limit (UEL) 3.8%
NFPA health rating 2 NFPA fire rating 2
NFPA reactivity rating 1 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1538
Sampling group
Sampler/Sampling media ORBO™ 303 (100/50 mg) [Sigma Aldrich 20019-U]
Sampling time*
Sampling volume (TWA)*

2-25 L

Sampling flow rate (TWA)*

0.01-1 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference NIOSH 2508 (fully validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

25 ppm (140 mg/m³)

REL-TWA

4 ppm (23 mg/m³)

TLV-TWA PEL-TWA

4 ppm (23 mg/m³)

PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C

5 ppm [1992]

PEL-C
Skin notation

N

Skin notation

N

Skin notation

N

Skin notation

N

Notes:

See 29 CFR 1910.1000 Table Z-1.

Notes: Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH

200 ppm

Carcinogenic classifications: TLV-A3, EPA-C Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Isophorone

NIOSH: Pocket Guide to Chemical Hazards - Isophorone

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Isophorone. See annual publication for most recent information.
  • EPA Air Toxics Website: Isophorone. U.S. Environmental Protection Agency Technology Transfer Network.
  • De Ceaurriz, J., Micillino, J.C., Bonnet, P. and Guenier, J.P.: Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett. 9(2): 137-143, 1981.
  • Pohanish, R.P. (editor): Isophorone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1342-1344.

Last Updated Date : 12/31/2020