DIMETHYL SULFATE†

Chemical Identification
Chemical Identification
CAS # 77-78-1
Formula

C₂H₆O₄S

Synonyms

dimethyl ester of sulfuric acid; dimethylsulfate; methyl sulfate

Physical Properties
Physical Properties
Physical description Colorless, oily liquid with a faint, onion-like odor.
Boiling point 370°F (decomposes) Molecular weight 126.1
Freezing point/melting point -25°F Vapor pressure 0.1 mmHg
Flash point 182°F Vapor density
Specific gravity 1.33 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating 4 NFPA fire rating 2
NFPA reactivity rating 1 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0960
Sampling group
Sampler/Sampling media Porapak Q tube (150/75 mg) [SKC 226-115]
Sampling time*
Sampling volume (TWA)*

10 L

Sampling flow rate (TWA)*

0.1 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FPD
Method reference OSHA PV2147 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device Detector tube
Model/Type Dräger - Dimethyl Sulfate 0.005/c, 6718701
Sampling information
(see manufacturer instructions)
200 strokes, 0.005-0.05 ppm range, uncertainty approx 50%
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

1 ppm (5 mg/m³)

REL-TWA

0.1 ppm (0.5 mg/m³)

TLV-TWA

0.1 ppm [1985]

PEL-TWA

0.1 ppm (0.5 mg/m³)

PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

Y

Skin notation

Y

Skin notation

Y

Skin notation

Y

Notes:

See 29 CFR 1910.1000 Table Z-1.

Notes:

CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION. See Appendix A

Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH

 7 ppm

Carcinogenic classifications: IARC-2A, NOSH-Ca, NTP-R, TLV-A3, EPA-B2 Notes:

Ca

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Dimethyl sulfate

NIOSH: Pocket Guide to Chemical Hazards - Dimethyl sulfate

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Dimethyl sulfate. See annual publication for most recent information.
  • EPA Air Toxics Website: Dimethyl sulfate. U.S. Environmental Protection Agency Technology Transfer Network.
  • NIOSH Registry of Toxic Effects of Chemical Substances: Sulfuric acid, dimethyl ester (RTECS # WS8225000).
  • Anonymous: Dimethyl sulfate. IARC Monogr. Eval. Carcinog. Risks Hum. 71(Pt. 2): 575-588, 1999.
  • Pohanish, R.P. (editor): Dimethyl Sulfate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 939-941.
  • Schettgen, T., Broding, H.C., Angerer, J. and Drexler, H.: Dimethyl sulphate: a hidden problem in occupational medicine. Occup. Environ. Med. 61(1): 73-75, 2004.
  • Wang, Y., Xia, J. and Wang, Q.: Clinical report on 62 cases of acute dimethyl sulfate intoxication. Am. J. Ind. Med. 13(4): 455-462, 1988.

Last Updated Date : 12/28/2020