1. OSHA Occupational Chemical Database
  2. TRICHLOROACETIC ACID
Label abbreviations descriptions

TRICHLOROACETIC ACID

Chemical Identification
Chemical Identification
CAS # 76-03-9
Formula

C₂HCl₃O₂
Synonyms

TCA; trichloroethanoic acid
Physical Properties
Physical Properties
Physical description Colorless to white, crystalline solid with a sharp, pungent odor.
Boiling point 388°F Molecular weight 163.39
Freezing point/melting point 136°F Vapor pressure 1 mmHg at 124°F
Flash point Vapor density 5.6
Specific gravity 1.62 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) T337
Sampling group
Sampler/Sampling media Silica gel tube (100/50 mg) [SKC 226-47-01]
Sampling time*
Sampling volume (TWA)*

10 L
Sampling flow rate (TWA)*

0.2 L/min
Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments HPLC-UV
Method reference OSHA PV2017 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA

1 ppm (7 mg/m³)

 TLV-TWA

0.5 ppm [2013]

 PEL-TWA

1 ppm (5 mg/m³)
PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

NA

 Skin notation

N

 Skin notation

N

 Skin notation

N
Notes:

Not established

 Notes: Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: IARC-3, TLV-A3, EPA-C Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Trichloroacetic acid

NIOSH: Pocket Guide to Chemical Hazards - Trichloroacetic acid

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Trichloroacetic acid. See annual publication for most recent information.
  • Bull R.J., et al.: Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene. Toxicol. Appl. Pharmacol. 182(1): 55-65, 2002.
  • Calafat, A.M., Kuklenyik, Z., Caudill, S.P. and Ashley, D.L.: Urinary levels of trichloroacetic acid, a disinfection by-product in chlorinated drinking water, in a human reference population. Environ. Health Perspect. 111(2): 151-154, 2003.
  • Forkert, P.-G., Lash, L., Tardif, R., Tanphaichitr, N., Vandevoort, C. and Moussa, M.: Identification of trichloroethylene and its metabolites in human seminal fluid of workers exposed to trichloroethylene. Drug Metab. Dispos. 31(3): 306-311, 2003.
  • Pohanish, R.P. (editor): Trichloroacetic Acid. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp.2239-2241.

Last Updated Date : 01/29/2021