TRIMETHYLAMINE

Chemical Identification
Chemical Identification
CAS # 75-50-3
Formula

C₃H₉N

Synonyms

N,N-dimethylmethanamine; TMA [Note: May be used in an aqueous solution (typically 25%, 30%, or 40% TMA.]

Physical Properties
Physical Properties
Physical description Colorless gas with a fishy, amine odor.
Boiling point 37.2°F Molecular weight 59.11
Freezing point/melting point -179°F Vapor pressure 1454 mmHg at 70°F
Flash point Vapor density 2.09
Specific gravity 0.633 at 68°F Ionization potential
Lower explosive limit (LEL) 2.0% Upper explosive limit (UEL) 11.6%
NFPA health rating 3 NFPA fire rating 4
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) T127
Sampling group
Sampler/Sampling media XAD-7 tube (80/40 mg) coated with phosphoric acid [SKC 226-98]
Sampling time*

100 min 

Sampling volume (TWA)*

10 L

Sampling flow rate (TWA)*

0.1 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference OSHA PV2060 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA

10 ppm (24 mg/m³)

TLV-TWA

5 ppm [2012]

PEL-TWA

5 ppm (12 mg/m³)

PEL-STEL REL-STEL

15 ppm (36 mg/m³)

TLV-STEL

15 ppm [2012]

PEL-STEL

15 ppm (36 mg/m³)

PEL-C REL-C TLV-C PEL-C
Skin notation

NA

Skin notation

N

Skin notation

N

Skin notation

N

Notes:

Not established

Notes: Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: Not listed Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

0.1/100 ppm/500 ppm

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Trimethylamine, anhydrous

NIOSH: Pocket Guide to Chemical Hazards - Trimethylamine

Literature References

  • NOAA: CAMEO Chemicals - Trimethylamine, aqueous solution.
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Trimethylamine. See annual publication for most recent information.
  • Cashman, J.R., et al.: Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria. Curr. Drug Metab. 4(2): 151-170, 2003.
  • Amoore, J.E. and Forrester, L.J.: Specific anosmia to trimethylamine: the fishy primary odor. J. Chem. Ecology 2(1): 49-56, 1976.
  • Fluhr, J.W., et al.: Additive impairment of the barrier function and irritation by biogenic amines and sodium lauryl sulphate: a controlled in vivo tandem irritation study. Skin Pharmacol. Physiol. 18(2): 88-97, 2005.
  • Kenyon, S., et al.: The passage of trimethylamine across rat and human skin. Food Chem. Toxicol. 42(10): 1619-1628, 2004.
  • Mitchell, S.C. and Smith, R.L.: Trimethylamine and odorous sweat. J. Inherit. Metab. Dis. 26(4): 415-416, 2003.
  • Pohanish, R.P. (editor): Trimethylamine. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2275-2277.
  • Shimizu, M., Cashman, J.R. and Yamazaki, H.: Transient trimethylaminuria related to menstruation. BMC Med. Genet. 8: 2, 2007.

Last Updated Date : 07/13/2021