1. OSHA Occupational Chemical Database
  2. CHLORODIFLUOROMETHANE
Label abbreviations descriptions

CHLORODIFLUOROMETHANE

Chemical Identification
Chemical Identification
CAS # 75-45-6
Formula

CHClF₂
Synonyms

difluorochloromethane; Fluorocarbon-22, Freon22; Genetron22; monochlorodifluoromethane; Refrigerant 22
Physical Properties
Physical Properties
Physical description Colorless gas with a faint, sweet odor.
Boiling point -41°F Molecular weight 86.5
Freezing point/melting point "-231°F" Vapor pressure 9.4 atm
Flash point Vapor density 3.11
Specific gravity 1.41 at -40°F Ionization potential 12.45 eV
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.)
Sampling group
Sampler/Sampling media
Sampling time*
Sampling volume (TWA)*
Sampling flow rate (TWA)*
Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments
Method reference
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA

1000 ppm (3500 mg/m³)

 TLV-TWA

1000 ppm [1990]

 PEL-TWA

1000 ppm (3500 mg/m³)
PEL-STEL REL-STEL

1250 ppm (4375 mg/m³)

 TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

NA

 Skin notation

N

 Skin notation

N

 Skin notation

N
Notes:

Not established

 Notes: Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: IARC-3, TLV-A4 Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Chlorodifluoromethane

NIOSH: Pocket Guide to Chemical Hazards - Chlorodifluoromethane

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Chlorodifluoromethane. See annual publication for most recent information.
  • U.S. EPA Integrated Risk Information System: Chlorodifluoromethane (CASRN 75-45-6).
  • Kintz, P., Baccino, E., Tracqui, A. and Mangin, P.: Headspace GC/MS testing for chlorodifluoromethane in two fatal cases. Forensic Sci. Int. 82(2): 171-175, 1996.
  • Kubota, T. and Miyata, A.: Acute inhalational exposure to chlorodifluoromethane (Freon-22): a report of 43 cases. Clin. Toxicol. (Phila.) 43(4): 305-308, 2005.
  • Nieuwenhuizen, M.S. and Groeneveld, F.R.: Formation of phosgene during welding activities in an atmosphere containing chlorinated hydrocarbons. AIHAJ 61(4): 539-543, 2000.
  • Pohanish, R.P. (editor): Chlorodifluoromethane. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 565-567.
  • Woollen, B. H., et al.: Human inhalation pharmacokinetics of chlorodifluoromethane (HCFC22). Int. Arch. Occup. Environ. Health 64(5): 383-387, 1992.

Last Updated Date : 01/31/2018